The Importance of Structural Anisotropy in Computational Models of Traumatic Brain Injury
Understanding the mechanisms of injury might prove useful in assisting the development of methods for the management and mitigation of traumatic brain injury (TBI). Computational head models can provide valuable insight into the multi-length-scale complexity associated with the primary nature of dif...
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doaj-38bf5f0c1c4440708a210f6f96e7b0472020-11-25T00:13:09ZengFrontiers Media S.A.Frontiers in Neurology1664-22952015-02-01610.3389/fneur.2015.00028122217The Importance of Structural Anisotropy in Computational Models of Traumatic Brain InjuryRika W. Carlsen0Nitin P. Daphalapurkar1Robert Morris UniversityJohns Hopkins UniversityUnderstanding the mechanisms of injury might prove useful in assisting the development of methods for the management and mitigation of traumatic brain injury (TBI). Computational head models can provide valuable insight into the multi-length-scale complexity associated with the primary nature of diffuse axonal injury. It involves understanding how the trauma to the head (at the cm length scale) translates to the white matter tissue (at the millimeter length scale), and even further down to the axonal-length scale, where physical injury to axons (e.g. axon separation) may occur. However, to accurately represent the development of TBI, the biofidelity of these computational models is of utmost importance. There has been a focused effort to improve the biofidelity of computational models by including more sophisticated material definitions and implementing physiologically relevant measures of injury. This paper summarizes recent computational studies that have incorporated structural anisotropy in both the material definition of the white matter and the injury criterion as a means to improve the predictive capabilities of computational models for TBI. We discuss the role of structural anisotropy on both the mechanical response of the brain tissue and on the development of injury. We also outline future directions in the computational modeling of TBI.http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00028/fullDiffuse Axonal Injurycomputational modelTraumatic Brain InjuryInjury criterionAxonal strain |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rika W. Carlsen Nitin P. Daphalapurkar |
spellingShingle |
Rika W. Carlsen Nitin P. Daphalapurkar The Importance of Structural Anisotropy in Computational Models of Traumatic Brain Injury Frontiers in Neurology Diffuse Axonal Injury computational model Traumatic Brain Injury Injury criterion Axonal strain |
author_facet |
Rika W. Carlsen Nitin P. Daphalapurkar |
author_sort |
Rika W. Carlsen |
title |
The Importance of Structural Anisotropy in Computational Models of Traumatic Brain Injury |
title_short |
The Importance of Structural Anisotropy in Computational Models of Traumatic Brain Injury |
title_full |
The Importance of Structural Anisotropy in Computational Models of Traumatic Brain Injury |
title_fullStr |
The Importance of Structural Anisotropy in Computational Models of Traumatic Brain Injury |
title_full_unstemmed |
The Importance of Structural Anisotropy in Computational Models of Traumatic Brain Injury |
title_sort |
importance of structural anisotropy in computational models of traumatic brain injury |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2015-02-01 |
description |
Understanding the mechanisms of injury might prove useful in assisting the development of methods for the management and mitigation of traumatic brain injury (TBI). Computational head models can provide valuable insight into the multi-length-scale complexity associated with the primary nature of diffuse axonal injury. It involves understanding how the trauma to the head (at the cm length scale) translates to the white matter tissue (at the millimeter length scale), and even further down to the axonal-length scale, where physical injury to axons (e.g. axon separation) may occur. However, to accurately represent the development of TBI, the biofidelity of these computational models is of utmost importance. There has been a focused effort to improve the biofidelity of computational models by including more sophisticated material definitions and implementing physiologically relevant measures of injury. This paper summarizes recent computational studies that have incorporated structural anisotropy in both the material definition of the white matter and the injury criterion as a means to improve the predictive capabilities of computational models for TBI. We discuss the role of structural anisotropy on both the mechanical response of the brain tissue and on the development of injury. We also outline future directions in the computational modeling of TBI. |
topic |
Diffuse Axonal Injury computational model Traumatic Brain Injury Injury criterion Axonal strain |
url |
http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00028/full |
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