WVMDA: Predicting miRNA–Disease Association Based on Weighted Voting

• Main Authors: Zhen-Wei Zhang, Zhen Gao, Chun-Hou Zheng, Lei Li, Su-Min Qi, Yu-Tian Wang
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2021-09-01
• Series: Frontiers in Genetics
• Subjects: miRNA-disease association; credibility similarity; weighted voting; miRNA; disease
• Online Access: https://www.frontiersin.org/articles/10.3389/fgene.2021.742992/full

An increasing number of experiments had verified that miRNA expression is related to human diseases. The miRNA expression profile may be an indicator of clinical diagnosis and provides a new direction for the prevention and treatment of complex diseases. In this work, we present a weighted voting-based model for predicting miRNA–disease association (WVMDA). To reasonably build a network of similarity, we established credibility similarity based on the reliability of known associations and used it to improve the original incomplete similarity. To eliminate noise interference as much as possible while maintaining more reliable similarity information, we developed a filter. More importantly, to ensure the fairness and efficiency of weighted voting, we focus on the design of weighting. Finally, cross-validation experiments and case studies are undertaken to verify the efficacy of the proposed model. The results showed that WVMDA could efficiently identify miRNAs associated with the disease.