Syndecan-4 in Tumor Cell Motility
Syndecan-4 (SDC4) is a ubiquitously expressed, transmembrane proteoglycan bearing heparan sulfate chains. SDC4 is involved in numerous inside-out and outside-in signaling processes, such as binding and sequestration of growth factors and extracellular matrix components, regulation of the activity of...
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doaj-38c7ebe5c11f4b4eb020033e0ff071552021-07-15T15:31:59ZengMDPI AGCancers2072-66942021-07-01133322332210.3390/cancers13133322Syndecan-4 in Tumor Cell MotilityAniko Keller-Pinter0Szuzina Gyulai-Nagy1Daniel Becsky2Laszlo Dux3Laszlo Rovo4Department of Biochemistry, Faculty of Medicine, University of Szeged, H-6720 Szeged, HungaryDepartment of Biochemistry, Faculty of Medicine, University of Szeged, H-6720 Szeged, HungaryDepartment of Biochemistry, Faculty of Medicine, University of Szeged, H-6720 Szeged, HungaryDepartment of Biochemistry, Faculty of Medicine, University of Szeged, H-6720 Szeged, HungaryDepartment of Oto-Rhino-Laryngology and Head-Neck Surgery, University of Szeged, H-6725 Szeged, HungarySyndecan-4 (SDC4) is a ubiquitously expressed, transmembrane proteoglycan bearing heparan sulfate chains. SDC4 is involved in numerous inside-out and outside-in signaling processes, such as binding and sequestration of growth factors and extracellular matrix components, regulation of the activity of the small GTPase Rac1, protein kinase C-alpha, the level of intracellular calcium, or the phosphorylation of focal adhesion kinase. The ability of this proteoglycan to link the extracellular matrix and actin cytoskeleton enables SDC4 to contribute to biological functions like cell adhesion and migration, cell proliferation, cytokinesis, cellular polarity, or mechanotransduction. The multiple roles of SDC4 in tumor pathogenesis and progression has already been demonstrated; therefore, the expression and signaling of SDC4 was investigated in several tumor types. SDC4 influences tumor progression by regulating cell proliferation as well as cell migration by affecting cell-matrix adhesion and several signaling pathways. Here, we summarize the general role of SDC4 in cell migration and tumor cell motility.https://www.mdpi.com/2072-6694/13/13/3322syndecan-4proteoglycanmigrationEMTmetastasiscancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aniko Keller-Pinter Szuzina Gyulai-Nagy Daniel Becsky Laszlo Dux Laszlo Rovo |
spellingShingle |
Aniko Keller-Pinter Szuzina Gyulai-Nagy Daniel Becsky Laszlo Dux Laszlo Rovo Syndecan-4 in Tumor Cell Motility Cancers syndecan-4 proteoglycan migration EMT metastasis cancer |
author_facet |
Aniko Keller-Pinter Szuzina Gyulai-Nagy Daniel Becsky Laszlo Dux Laszlo Rovo |
author_sort |
Aniko Keller-Pinter |
title |
Syndecan-4 in Tumor Cell Motility |
title_short |
Syndecan-4 in Tumor Cell Motility |
title_full |
Syndecan-4 in Tumor Cell Motility |
title_fullStr |
Syndecan-4 in Tumor Cell Motility |
title_full_unstemmed |
Syndecan-4 in Tumor Cell Motility |
title_sort |
syndecan-4 in tumor cell motility |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2021-07-01 |
description |
Syndecan-4 (SDC4) is a ubiquitously expressed, transmembrane proteoglycan bearing heparan sulfate chains. SDC4 is involved in numerous inside-out and outside-in signaling processes, such as binding and sequestration of growth factors and extracellular matrix components, regulation of the activity of the small GTPase Rac1, protein kinase C-alpha, the level of intracellular calcium, or the phosphorylation of focal adhesion kinase. The ability of this proteoglycan to link the extracellular matrix and actin cytoskeleton enables SDC4 to contribute to biological functions like cell adhesion and migration, cell proliferation, cytokinesis, cellular polarity, or mechanotransduction. The multiple roles of SDC4 in tumor pathogenesis and progression has already been demonstrated; therefore, the expression and signaling of SDC4 was investigated in several tumor types. SDC4 influences tumor progression by regulating cell proliferation as well as cell migration by affecting cell-matrix adhesion and several signaling pathways. Here, we summarize the general role of SDC4 in cell migration and tumor cell motility. |
topic |
syndecan-4 proteoglycan migration EMT metastasis cancer |
url |
https://www.mdpi.com/2072-6694/13/13/3322 |
work_keys_str_mv |
AT anikokellerpinter syndecan4intumorcellmotility AT szuzinagyulainagy syndecan4intumorcellmotility AT danielbecsky syndecan4intumorcellmotility AT laszlodux syndecan4intumorcellmotility AT laszlorovo syndecan4intumorcellmotility |
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1721299769612042240 |