Effect of Crude and Decaffeinated Extracts of Cola nitida Seeds on Male Reproductive System in Swiss Albino Rats

• Main Authors: J.O Ogundipe, O. A. Afolabi, O. S.Saka
• Format: Article
• Language: English
• Published: Krishna Institute of Medical Sciences University 2016-10-01
• Series: Journal of Krishna Institute of Medical Sciences University
• Subjects: Kola Nut Extract (Crude and Decaffeinated); Male Reproductive System; Albino Rat; Hormonal Assay; Sperm Quality
• Online Access: http://jkimsu.com/jkimsu-vol5no4/JKIMSU,%20Vol.%205,%20No.%204,%20Oct-Dec%202016%20Page%2010-17.pdf

Background: Caffeine is present in kola nut and xanthine stimulants which are used as a psychoactive drug. Therefore, the effect of kola nut (Cola nitida) extract was carried out on male reproductive system in male albino rats. Aim and Objectives: This study was aimed to determine the effect of oral administration of Crude Extract of Kola (CEK) and Decaffeinated Extract of Kola (DEK) on the reproductive function in male Swiss albino rats. Material and Methods: Twenty-four adult male albino rats were used for this study, they were assigned into three groups consisting eight rats each. Group 1 (control group) received (8mg/kg bw) of distilled water for six weeks, Group 2 (crude extract group) received (8mg/kg bw) of CEK for six weeks, and Group 3 (decaffeinated extract group) was treated with (8mg/kg bw) of DEK for six weeks. Result: CEK showed no significant decrease in the body weight and sperm count when compared with the control group. No significant difference in seminal parameter (motility, morphology, viability), organ weight (testis) and hormonal assay (testosterone, follicle stimulating hormone, luteinizing hormone) when compared with the control group. DEK showed no significant different in body weight, hormonal assay (testosterone and follicle stimulating hormone, seminal parameter (sperm viability, count, morphology and motility), organ weight (testes and epipidymis) of the animal; however significant increase was observed in luteinizing hormone when compared with control group. Asignificant increase in the sperm count of decaffeinated group was observed (p = 0.02) when compared with crude group. Conclusion: This study indicates that CEK and DEK have little effects on male reproductive system.