Morphology of Pyramidal Neurons in the Rat Prefrontal Cortex: Lateralized Dendritic Remodeling by Chronic Stress
The prefrontal cortex (PFC) plays an important role in the stress response. We filled pyramidal neurons in PFC layer III with neurobiotin and analyzed dendrites in rats submitted to chronic restraint stress and in controls. In the right prelimbic cortex (PL) of controls, apical and distal dendrites...
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2007-01-01
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Series: | Neural Plasticity |
Online Access: | http://dx.doi.org/10.1155/2007/46276 |
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doaj-38d13c729a474147b151c8c98438274a2020-11-24T23:54:15ZengHindawi LimitedNeural Plasticity2090-59041687-54432007-01-01200710.1155/2007/4627646276Morphology of Pyramidal Neurons in the Rat Prefrontal Cortex: Lateralized Dendritic Remodeling by Chronic StressClaudia Perez-Cruz0Jeanine I. H. Müller-Keuker1Urs Heilbronner2Eberhard Fuchs3Gabriele Flügge4Clinical Neurobiology Laboratory, German Primate Center, Göttingen 37077, GermanyClinical Neurobiology Laboratory, German Primate Center, Göttingen 37077, GermanyClinical Neurobiology Laboratory, German Primate Center, Göttingen 37077, GermanyClinical Neurobiology Laboratory, German Primate Center, Göttingen 37077, GermanyClinical Neurobiology Laboratory, German Primate Center, Göttingen 37077, GermanyThe prefrontal cortex (PFC) plays an important role in the stress response. We filled pyramidal neurons in PFC layer III with neurobiotin and analyzed dendrites in rats submitted to chronic restraint stress and in controls. In the right prelimbic cortex (PL) of controls, apical and distal dendrites were longer than in the left PL. Stress reduced the total length of apical dendrites in right PL and abolished the hemispheric difference. In right infralimbic cortex (IL) of controls, proximal apical dendrites were longer than in left IL, and stress eliminated this hemispheric difference. No hemispheric difference was detected in anterior cingulate cortex (ACx) of controls, but stress reduced apical dendritic length in left ACx. These data demonstrate interhemispheric differences in the morphology of pyramidal neurons in PL and IL of control rats and selective effects of stress on the right hemisphere. In contrast, stress reduced dendritic length in the left ACx.http://dx.doi.org/10.1155/2007/46276 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Claudia Perez-Cruz Jeanine I. H. Müller-Keuker Urs Heilbronner Eberhard Fuchs Gabriele Flügge |
spellingShingle |
Claudia Perez-Cruz Jeanine I. H. Müller-Keuker Urs Heilbronner Eberhard Fuchs Gabriele Flügge Morphology of Pyramidal Neurons in the Rat Prefrontal Cortex: Lateralized Dendritic Remodeling by Chronic Stress Neural Plasticity |
author_facet |
Claudia Perez-Cruz Jeanine I. H. Müller-Keuker Urs Heilbronner Eberhard Fuchs Gabriele Flügge |
author_sort |
Claudia Perez-Cruz |
title |
Morphology of Pyramidal Neurons in the Rat Prefrontal Cortex: Lateralized Dendritic Remodeling by Chronic Stress |
title_short |
Morphology of Pyramidal Neurons in the Rat Prefrontal Cortex: Lateralized Dendritic Remodeling by Chronic Stress |
title_full |
Morphology of Pyramidal Neurons in the Rat Prefrontal Cortex: Lateralized Dendritic Remodeling by Chronic Stress |
title_fullStr |
Morphology of Pyramidal Neurons in the Rat Prefrontal Cortex: Lateralized Dendritic Remodeling by Chronic Stress |
title_full_unstemmed |
Morphology of Pyramidal Neurons in the Rat Prefrontal Cortex: Lateralized Dendritic Remodeling by Chronic Stress |
title_sort |
morphology of pyramidal neurons in the rat prefrontal cortex: lateralized dendritic remodeling by chronic stress |
publisher |
Hindawi Limited |
series |
Neural Plasticity |
issn |
2090-5904 1687-5443 |
publishDate |
2007-01-01 |
description |
The prefrontal cortex (PFC) plays an important role in the stress response. We filled pyramidal neurons in PFC layer III with neurobiotin and analyzed dendrites in rats submitted to chronic restraint stress and in controls.
In the right prelimbic cortex (PL) of controls, apical and distal dendrites were longer than in the left PL. Stress reduced the total length of apical dendrites in right PL and abolished the hemispheric difference. In right infralimbic cortex (IL) of controls, proximal apical dendrites were longer than in left IL, and stress eliminated this hemispheric difference. No hemispheric difference was detected in anterior cingulate cortex (ACx) of controls, but stress reduced apical dendritic length in left ACx. These data demonstrate interhemispheric differences in the morphology of pyramidal neurons in PL and IL of control rats and selective effects of stress on the right hemisphere. In contrast, stress reduced dendritic length in the left ACx. |
url |
http://dx.doi.org/10.1155/2007/46276 |
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