Hsa-miR-330-5p Aggravates Thyroid Carcinoma via Targeting FOXE1

• Main Authors: Yuxia Wang, Zhaozhe Liu, Xiangning Ren, Nan Sun, Qiuhua Li, Che Bian
• Format: Article
• Language: English
• Published: Hindawi Limited 2021-01-01
• Series: Journal of Oncology
• Online Access: http://dx.doi.org/10.1155/2021/1070365

Background. Thyroid carcinoma (TC) is one of the frequent endocrine malignancies, and growing evidence suggests that aberrant microRNA (miRNA) expression contributes to TC development and progression. Nevertheless, the function of miR-330-5p in the progression of TC remains unknown. Methods. The expression levels of miR-330-5 in patients with thyroid carcinoma and healthy controls were detected, and their potential diagnostic and prognostic values were analyzed. Results. In this study, we firstly found that miR-330-5p expression was markedly upregulated in TC tissue and cell lines. Functionally, the downregulation of miR-330-5p suppressed TC cell proliferation, migration, and invasion. Further studies revealed that miR-330-5p negatively regulated the expression of forkhead box E1 (FOXE1). More importantly, the results of rescue experiments suggested that FOXE1 overexpression reduced the positive effects of miR-330-5p overexpression in TPC-1 and K-1 cells. Conclusions. This work revealed that miR-330-5p facilitated the TC progression through targeting FOXE1, which may offer novel therapeutic options for TC.