Morphology–Dependent Electrochemical Sensing Properties of Iron Oxide–Graphene Oxide Nanohybrids for Dopamine and Uric Acid

• Main Authors: Zhaotian Cai, Yabing Ye, Xuan Wan, Jun Liu, Shihui Yang, Yonghui Xia, Guangli Li, Quanguo He
• Format: Article
• Language: English
• Published: MDPI AG 2019-06-01
• Series: Nanomaterials
• Subjects: morphology-dependent; α-Fe₂O₃ nanoparticles; GO; uric acid; dopamine; voltammetric detection
• Online Access: https://www.mdpi.com/2079-4991/9/6/835

Various morphologies of iron oxide nanoparticles (Fe₂O₃ NPs), including cubic, thorhombic and discal shapes were synthesized by a facile meta-ion mediated hydrothermal route. To further improve the electrochemical sensing properties, discal Fe₂O₃ NPs with the highest electrocatalytic activity were coupled with graphene oxide (GO) nanosheets. The surface morphology, microstructures and electrochemical properties of the obtained Fe₂O₃ NPs and Fe₂O₃/GO nanohybrids were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) techniques. As expected, the electrochemical performances were found to be highly related to morphology. The discal Fe₂O₃ NPs coupled with GO showed remarkable electrocatalytic activity toward the oxidation of dopamine (DA) and uric acid (UA), due to their excellent synergistic effect. The electrochemical responses of both DA and UA were linear to their concentrations in the ranges of 0.02−10 μM and 10−100 μM, with very low limits of detection (LOD) of 3.2 nM and 2.5 nM for DA and UA, respectively. Moreover, the d-Fe₂O₃/GO nanohybrids showed good selectivity and reproducibility. The proposed d-Fe₂O₃/GO/GCE realized the simultaneous detection of DA and UA in human serum and urine samples with satisfactory recoveries.