Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells.
Viruses subvert macromolecular pathways in infected host cells to aid in viral gene amplification or to counteract innate immune responses. Roles for host-encoded, noncoding RNAs, including microRNAs, have been found to provide pro- and anti-viral functions. Recently, circular RNAs (circRNAs), that...
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Online Access: | https://doi.org/10.1371/journal.ppat.1008346 |
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doaj-38ea0f3185e643248674bdc9e8dbdeb22021-04-21T17:16:12ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742020-08-01168e100834610.1371/journal.ppat.1008346Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells.Tzu-Chun ChenMarc Tallo-ParraQian M CaoSebastian KadenerRené BöttcherGemma Pérez-VilaróPakpoom BoonchuenKunlaya SomboonwiwatJuana DíezPeter SarnowViruses subvert macromolecular pathways in infected host cells to aid in viral gene amplification or to counteract innate immune responses. Roles for host-encoded, noncoding RNAs, including microRNAs, have been found to provide pro- and anti-viral functions. Recently, circular RNAs (circRNAs), that are generated by a nuclear back-splicing mechanism of pre-mRNAs, have been implicated to have roles in DNA virus-infected cells. This study examines the circular RNA landscape in uninfected and hepatitis C virus (HCV)-infected liver cells. Results showed that the abundances of distinct classes of circRNAs were up-regulated or down-regulated in infected cells. Identified circRNAs displayed pro-viral effects. One particular up-regulated circRNA, circPSD3, displayed a very pronounced effect on viral RNA abundances in both hepatitis C virus- and Dengue virus-infected cells. Though circPSD3 has been shown to bind factor eIF4A3 that modulates the cellular nonsense-mediated decay (NMD) pathway, circPSD3 regulates RNA amplification in a pro-viral manner at a post-translational step, while eIF4A3 exhibits the anti-viral property of the NMD pathway. Findings from the global analyses of the circular RNA landscape argue that pro-, and likely, anti-viral functions are executed by circRNAs that modulate viral gene expression as well as host pathways. Because of their long half-lives, circRNAs likely play hitherto unknown, important roles in viral pathogenesis.https://doi.org/10.1371/journal.ppat.1008346 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tzu-Chun Chen Marc Tallo-Parra Qian M Cao Sebastian Kadener René Böttcher Gemma Pérez-Vilaró Pakpoom Boonchuen Kunlaya Somboonwiwat Juana Díez Peter Sarnow |
spellingShingle |
Tzu-Chun Chen Marc Tallo-Parra Qian M Cao Sebastian Kadener René Böttcher Gemma Pérez-Vilaró Pakpoom Boonchuen Kunlaya Somboonwiwat Juana Díez Peter Sarnow Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells. PLoS Pathogens |
author_facet |
Tzu-Chun Chen Marc Tallo-Parra Qian M Cao Sebastian Kadener René Böttcher Gemma Pérez-Vilaró Pakpoom Boonchuen Kunlaya Somboonwiwat Juana Díez Peter Sarnow |
author_sort |
Tzu-Chun Chen |
title |
Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells. |
title_short |
Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells. |
title_full |
Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells. |
title_fullStr |
Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells. |
title_full_unstemmed |
Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells. |
title_sort |
host-derived circular rnas display proviral activities in hepatitis c virus-infected cells. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Pathogens |
issn |
1553-7366 1553-7374 |
publishDate |
2020-08-01 |
description |
Viruses subvert macromolecular pathways in infected host cells to aid in viral gene amplification or to counteract innate immune responses. Roles for host-encoded, noncoding RNAs, including microRNAs, have been found to provide pro- and anti-viral functions. Recently, circular RNAs (circRNAs), that are generated by a nuclear back-splicing mechanism of pre-mRNAs, have been implicated to have roles in DNA virus-infected cells. This study examines the circular RNA landscape in uninfected and hepatitis C virus (HCV)-infected liver cells. Results showed that the abundances of distinct classes of circRNAs were up-regulated or down-regulated in infected cells. Identified circRNAs displayed pro-viral effects. One particular up-regulated circRNA, circPSD3, displayed a very pronounced effect on viral RNA abundances in both hepatitis C virus- and Dengue virus-infected cells. Though circPSD3 has been shown to bind factor eIF4A3 that modulates the cellular nonsense-mediated decay (NMD) pathway, circPSD3 regulates RNA amplification in a pro-viral manner at a post-translational step, while eIF4A3 exhibits the anti-viral property of the NMD pathway. Findings from the global analyses of the circular RNA landscape argue that pro-, and likely, anti-viral functions are executed by circRNAs that modulate viral gene expression as well as host pathways. Because of their long half-lives, circRNAs likely play hitherto unknown, important roles in viral pathogenesis. |
url |
https://doi.org/10.1371/journal.ppat.1008346 |
work_keys_str_mv |
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