The Effect of Non-invasive Mechanic Ventilation Treatment on Lactate Level in Sleep-Related Breathing Disorders
Objective Lactate, as an indicator of hypoxia, may be useful in sleep-related breathing disorders to identify higher risk groups and monitor the effectiveness of positive airway pressure (PAP) treatment. We aimed to investigate the change in arterial lactate level in blood after PAP treatment in pa...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Galenos Yayinevi
2016-09-01
|
Series: | Türk Uyku Tıbbı Dergisi |
Subjects: | |
Online Access: | http://jtsm.org/archives/archive-detail/article-preview/the-effect-of-non-invasive-mechanic-ventilation-tr/15986 |
id |
doaj-38f642ab7e0f4fc1b2890a6c871144f3 |
---|---|
record_format |
Article |
spelling |
doaj-38f642ab7e0f4fc1b2890a6c871144f32020-11-24T22:44:34ZengGalenos YayineviTürk Uyku Tıbbı Dergisi2148-15042016-09-0133556410.4274/jtsm.209The Effect of Non-invasive Mechanic Ventilation Treatment on Lactate Level in Sleep-Related Breathing DisordersReyhan Gümüşburun0Yelda Varol1Zeynep Zeren Uçar2Fadil Murat Gümüşburun3Erdem Atalay Çetinkaya4Özlem Egemen Tüzel5Hüseyin Halilçolar6Dr. Suat Seren Chest Diseases And Surgery Training And Research Hospital, Clinic Of Chest Diseases, Izmir, TurkeyDr. Suat Seren Chest Diseases And Surgery Training And Research Hospital, Clinic Of Chest Diseases, Izmir, TurkeyDr. Suat Seren Chest Diseases And Surgery Training And Research Hospital, Clinic Of Chest Diseases, Izmir, TurkeyNizip Zerdegümlü Ayse Çapan Family Health Center, Gaziantep, TurkeyAntalya Atatürk State Hospital, Clinic Of Otorhinolaryngology, Antalya, TurkeyDr. Suat Seren Chest Diseases And Surgery Training And Research Hospital, Clinic Of Chest Diseases, Izmir, TurkeyDr. Suat Seren Chest Diseases And Surgery Training And Research Hospital, Clinic Of Chest Diseases, Izmir, TurkeyObjective Lactate, as an indicator of hypoxia, may be useful in sleep-related breathing disorders to identify higher risk groups and monitor the effectiveness of positive airway pressure (PAP) treatment. We aimed to investigate the change in arterial lactate level in blood after PAP treatment in patients with obstructive sleep apnea (OSA) and sleep-related hypoventilation and hypoxemic syndromes and its applicability for monitoring this change regarding the effectiveness of the treatment. Materials and Methods PAP titration was applied to 64 OSA patients diagnosed with polysomnography. Measurements included pulmonary function testing, overnight PAP titration, arterial blood gases, and analysis of arterial lactate before and after titration. Overnight lactate level change was calculated. Results Of the 64 patients in the study, 49 were in the OSA group and 15 were in the Obesity Hypoventilation syndrome plus OSA group. No statistically significant difference was detected among the patients in terms of lactate levels before and after PAP treatment [1.97 (±0.7) - 1.98 (±0.6)] (p>0.05). In the OSA patient group, we detected an inverse relationship between Lactate and pre-treatment non-rapid eye movement 1-2% (r=-0.328, p=0.021), T 90% (r=-0.356, p=0.012), and total apnea hypopnea index (AHI) (r=-0.424, p=0.002). Lactate is found to be positively correlated with pre-treatment measured oxygen saturation (r=0.396, p=0.005), and with minimum oxygen saturation (r=0.361, p=0.011). Conclusion Our study showed that there is a relationship between AHI, average and minimum oxygen saturation and T 90% and lactate difference, which are severity indicators for OSA. These results suggest that PAP treatment may prevent possible lactate increase.http://jtsm.org/archives/archive-detail/article-preview/the-effect-of-non-invasive-mechanic-ventilation-tr/15986Apneahypoxiaobstructive sleep apneapolysomnographypositive airway pressure treatment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Reyhan Gümüşburun Yelda Varol Zeynep Zeren Uçar Fadil Murat Gümüşburun Erdem Atalay Çetinkaya Özlem Egemen Tüzel Hüseyin Halilçolar |
spellingShingle |
Reyhan Gümüşburun Yelda Varol Zeynep Zeren Uçar Fadil Murat Gümüşburun Erdem Atalay Çetinkaya Özlem Egemen Tüzel Hüseyin Halilçolar The Effect of Non-invasive Mechanic Ventilation Treatment on Lactate Level in Sleep-Related Breathing Disorders Türk Uyku Tıbbı Dergisi Apnea hypoxia obstructive sleep apnea polysomnography positive airway pressure treatment |
author_facet |
Reyhan Gümüşburun Yelda Varol Zeynep Zeren Uçar Fadil Murat Gümüşburun Erdem Atalay Çetinkaya Özlem Egemen Tüzel Hüseyin Halilçolar |
author_sort |
Reyhan Gümüşburun |
title |
The Effect of Non-invasive Mechanic Ventilation Treatment on Lactate Level in Sleep-Related Breathing Disorders |
title_short |
The Effect of Non-invasive Mechanic Ventilation Treatment on Lactate Level in Sleep-Related Breathing Disorders |
title_full |
The Effect of Non-invasive Mechanic Ventilation Treatment on Lactate Level in Sleep-Related Breathing Disorders |
title_fullStr |
The Effect of Non-invasive Mechanic Ventilation Treatment on Lactate Level in Sleep-Related Breathing Disorders |
title_full_unstemmed |
The Effect of Non-invasive Mechanic Ventilation Treatment on Lactate Level in Sleep-Related Breathing Disorders |
title_sort |
effect of non-invasive mechanic ventilation treatment on lactate level in sleep-related breathing disorders |
publisher |
Galenos Yayinevi |
series |
Türk Uyku Tıbbı Dergisi |
issn |
2148-1504 |
publishDate |
2016-09-01 |
description |
Objective
Lactate, as an indicator of hypoxia, may be useful in sleep-related breathing disorders to identify higher risk groups and monitor the effectiveness of positive airway pressure (PAP) treatment. We aimed to investigate the change in arterial lactate level in blood after PAP treatment in patients with obstructive sleep apnea (OSA) and sleep-related hypoventilation and hypoxemic syndromes and its applicability for monitoring this change regarding the effectiveness of the treatment.
Materials and Methods
PAP titration was applied to 64 OSA patients diagnosed with polysomnography. Measurements included pulmonary function testing, overnight PAP titration, arterial blood gases, and analysis of arterial lactate before and after titration. Overnight lactate level change was calculated.
Results
Of the 64 patients in the study, 49 were in the OSA group and 15 were in the Obesity Hypoventilation syndrome plus OSA group. No statistically significant difference was detected among the patients in terms of lactate levels before and after PAP treatment [1.97 (±0.7) - 1.98 (±0.6)] (p>0.05). In the OSA patient group, we detected an inverse relationship between Lactate and pre-treatment non-rapid eye movement 1-2% (r=-0.328, p=0.021), T 90% (r=-0.356, p=0.012), and total apnea hypopnea index (AHI) (r=-0.424, p=0.002). Lactate is found to be positively correlated with pre-treatment measured oxygen saturation (r=0.396, p=0.005), and with minimum oxygen saturation (r=0.361, p=0.011).
Conclusion
Our study showed that there is a relationship between AHI, average and minimum oxygen saturation and T 90% and lactate difference, which are severity indicators for OSA. These results suggest that PAP treatment may prevent possible lactate increase. |
topic |
Apnea hypoxia obstructive sleep apnea polysomnography positive airway pressure treatment |
url |
http://jtsm.org/archives/archive-detail/article-preview/the-effect-of-non-invasive-mechanic-ventilation-tr/15986 |
work_keys_str_mv |
AT reyhangumusburun theeffectofnoninvasivemechanicventilationtreatmentonlactatelevelinsleeprelatedbreathingdisorders AT yeldavarol theeffectofnoninvasivemechanicventilationtreatmentonlactatelevelinsleeprelatedbreathingdisorders AT zeynepzerenucar theeffectofnoninvasivemechanicventilationtreatmentonlactatelevelinsleeprelatedbreathingdisorders AT fadilmuratgumusburun theeffectofnoninvasivemechanicventilationtreatmentonlactatelevelinsleeprelatedbreathingdisorders AT erdematalaycetinkaya theeffectofnoninvasivemechanicventilationtreatmentonlactatelevelinsleeprelatedbreathingdisorders AT ozlemegementuzel theeffectofnoninvasivemechanicventilationtreatmentonlactatelevelinsleeprelatedbreathingdisorders AT huseyinhalilcolar theeffectofnoninvasivemechanicventilationtreatmentonlactatelevelinsleeprelatedbreathingdisorders AT reyhangumusburun effectofnoninvasivemechanicventilationtreatmentonlactatelevelinsleeprelatedbreathingdisorders AT yeldavarol effectofnoninvasivemechanicventilationtreatmentonlactatelevelinsleeprelatedbreathingdisorders AT zeynepzerenucar effectofnoninvasivemechanicventilationtreatmentonlactatelevelinsleeprelatedbreathingdisorders AT fadilmuratgumusburun effectofnoninvasivemechanicventilationtreatmentonlactatelevelinsleeprelatedbreathingdisorders AT erdematalaycetinkaya effectofnoninvasivemechanicventilationtreatmentonlactatelevelinsleeprelatedbreathingdisorders AT ozlemegementuzel effectofnoninvasivemechanicventilationtreatmentonlactatelevelinsleeprelatedbreathingdisorders AT huseyinhalilcolar effectofnoninvasivemechanicventilationtreatmentonlactatelevelinsleeprelatedbreathingdisorders |
_version_ |
1725691037567942656 |