Checking NEKs: Overcoming a Bottleneck in Human Diseases
In previous years, several kinases, such as phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR), and extracellular-signal-regulated kinase (ERK), have been linked to important human diseases, although some kinase families remain neglected in terms of research, hiding their relevan...
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doaj-38fad23c8a8f44d997ffdcdb83c2dfb42020-11-25T02:23:40ZengMDPI AGMolecules1420-30492020-04-01251778177810.3390/molecules25081778Checking NEKs: Overcoming a Bottleneck in Human DiseasesAndressa Peres de Oliveira0Luidy Kazuo Issayama1Isadora Carolina Betim Pavan2Fernando Riback Silva3Talita Diniz Melo-Hanchuk4Fernando Moreira Simabuco5Jörg Kobarg6Instituto de Biologia, Departamento de Bioquímica e Biologia Tecidual, Universidade Estadual de Campinas, Campinas, São Paulo 13083-862, BrazilInstituto de Biologia, Departamento de Bioquímica e Biologia Tecidual, Universidade Estadual de Campinas, Campinas, São Paulo 13083-862, BrazilInstituto de Biologia, Departamento de Bioquímica e Biologia Tecidual, Universidade Estadual de Campinas, Campinas, São Paulo 13083-862, BrazilInstituto de Biologia, Departamento de Bioquímica e Biologia Tecidual, Universidade Estadual de Campinas, Campinas, São Paulo 13083-862, BrazilInstituto de Biologia, Departamento de Bioquímica e Biologia Tecidual, Universidade Estadual de Campinas, Campinas, São Paulo 13083-862, BrazilLaboratório Multidisciplinar em Alimentos e Saúde, Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas, São Paulo 13484-350, BrazilFaculdade de Ciências Farmacêuticas, Universidade Estadual de Campinas, Campinas, São Paulo 13083-871, BrazilIn previous years, several kinases, such as phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR), and extracellular-signal-regulated kinase (ERK), have been linked to important human diseases, although some kinase families remain neglected in terms of research, hiding their relevance to therapeutic approaches. Here, a review regarding the NEK family is presented, shedding light on important information related to NEKs and human diseases. NEKs are a large group of homologous kinases with related functions and structures that participate in several cellular processes such as the cell cycle, cell division, cilia formation, and the DNA damage response. The review of the literature points to the pivotal participation of NEKs in important human diseases, like different types of cancer, diabetes, ciliopathies and central nervous system related and inflammatory-related diseases. The different known regulatory molecular mechanisms specific to each NEK are also presented, relating to their involvement in different diseases. In addition, important information about NEKs remains to be elucidated and is highlighted in this review, showing the need for other studies and research regarding this kinase family. Therefore, the NEK family represents an important group of kinases with potential applications in the therapy of human diseases.https://www.mdpi.com/1420-3049/25/8/1778NEKscancerdisorders |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andressa Peres de Oliveira Luidy Kazuo Issayama Isadora Carolina Betim Pavan Fernando Riback Silva Talita Diniz Melo-Hanchuk Fernando Moreira Simabuco Jörg Kobarg |
spellingShingle |
Andressa Peres de Oliveira Luidy Kazuo Issayama Isadora Carolina Betim Pavan Fernando Riback Silva Talita Diniz Melo-Hanchuk Fernando Moreira Simabuco Jörg Kobarg Checking NEKs: Overcoming a Bottleneck in Human Diseases Molecules NEKs cancer disorders |
author_facet |
Andressa Peres de Oliveira Luidy Kazuo Issayama Isadora Carolina Betim Pavan Fernando Riback Silva Talita Diniz Melo-Hanchuk Fernando Moreira Simabuco Jörg Kobarg |
author_sort |
Andressa Peres de Oliveira |
title |
Checking NEKs: Overcoming a Bottleneck in Human Diseases |
title_short |
Checking NEKs: Overcoming a Bottleneck in Human Diseases |
title_full |
Checking NEKs: Overcoming a Bottleneck in Human Diseases |
title_fullStr |
Checking NEKs: Overcoming a Bottleneck in Human Diseases |
title_full_unstemmed |
Checking NEKs: Overcoming a Bottleneck in Human Diseases |
title_sort |
checking neks: overcoming a bottleneck in human diseases |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2020-04-01 |
description |
In previous years, several kinases, such as phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR), and extracellular-signal-regulated kinase (ERK), have been linked to important human diseases, although some kinase families remain neglected in terms of research, hiding their relevance to therapeutic approaches. Here, a review regarding the NEK family is presented, shedding light on important information related to NEKs and human diseases. NEKs are a large group of homologous kinases with related functions and structures that participate in several cellular processes such as the cell cycle, cell division, cilia formation, and the DNA damage response. The review of the literature points to the pivotal participation of NEKs in important human diseases, like different types of cancer, diabetes, ciliopathies and central nervous system related and inflammatory-related diseases. The different known regulatory molecular mechanisms specific to each NEK are also presented, relating to their involvement in different diseases. In addition, important information about NEKs remains to be elucidated and is highlighted in this review, showing the need for other studies and research regarding this kinase family. Therefore, the NEK family represents an important group of kinases with potential applications in the therapy of human diseases. |
topic |
NEKs cancer disorders |
url |
https://www.mdpi.com/1420-3049/25/8/1778 |
work_keys_str_mv |
AT andressaperesdeoliveira checkingneksovercomingabottleneckinhumandiseases AT luidykazuoissayama checkingneksovercomingabottleneckinhumandiseases AT isadoracarolinabetimpavan checkingneksovercomingabottleneckinhumandiseases AT fernandoribacksilva checkingneksovercomingabottleneckinhumandiseases AT talitadinizmelohanchuk checkingneksovercomingabottleneckinhumandiseases AT fernandomoreirasimabuco checkingneksovercomingabottleneckinhumandiseases AT jorgkobarg checkingneksovercomingabottleneckinhumandiseases |
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