Overexpression of p16INK4a Serves as Prognostic Marker in Squamous Cell Vulvar Cancer Patients Treated With Radiotherapy Irrespective of HPV-Status

Overexpression of p16INK4a Serves as Prognostic Marker in Squamous Cell Vulvar Cancer Patients Treated With Radiotherapy Irrespective of HPV-Status

Purpose: We aimed to evaluate the impact of HPV-driven carcinogenesis on outcome in vulvar squamous cell carcinoma patients (VSCC) treated with radiotherapy.Methods and Materials: Analysis of clinical, pathological, and treatment data, HPV DNA-detection and -genotyping as well as p16INK4a immunohist...

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Bibliographic Details
Main Authors: Nathalie Arians, Elena-Sophie Prigge, Tereza Nachtigall, Miriam Reuschenbach, Stefan Alexander Koerber, Juergen Debus, Magnus von Knebel Doeberitz, Katja Lindel
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Oncology
Subjects:
vulvar squamous cell carcinoma
human papillomavirus
p16INK4a
radiotherapy
prognostic factors
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00891/full

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