Circumscribed choroidal hemangioma: Clinical features and outcomes by age category in 458 cases
Purpose: To investigate features and outcomes of circumscribed choroidal hemangioma by patient age. Methods: Retrospective review of circumscribed choroidal hemangioma from 3/29/1967–6/4/2018 based on age at presentation (≤20 vs. >20–50 vs. >50 years). Results: There were 458 circumscribed cho...
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Wolters Kluwer Medknow Publications
2019-07-01
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doaj-3912bceb43654916b9901fa3b517daae2021-04-02T20:12:39ZengWolters Kluwer Medknow PublicationsSaudi Journal of Ophthalmology1319-45342019-07-01333219228Circumscribed choroidal hemangioma: Clinical features and outcomes by age category in 458 casesLauren A. Dalvin0Li-Anne S. Lim1Michael Chang2Sanika Udyaver3Mehdi Mazloumi4Pornpattana Vichitvejpaisal5Grace L. Su6Eleni Florakis7Arman Mashayekhi8Jerry A. Shields9Carol L. Shields10Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, 840 Walnut Street, Suite 1440, Philadelphia, PA 19107, United States; Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, United StatesOcular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, 840 Walnut Street, Suite 1440, Philadelphia, PA 19107, United StatesOcular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, 840 Walnut Street, Suite 1440, Philadelphia, PA 19107, United StatesOcular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, 840 Walnut Street, Suite 1440, Philadelphia, PA 19107, United StatesOcular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, 840 Walnut Street, Suite 1440, Philadelphia, PA 19107, United StatesOcular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, 840 Walnut Street, Suite 1440, Philadelphia, PA 19107, United States; Chulabhorn Hospital, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, ThailandOcular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, 840 Walnut Street, Suite 1440, Philadelphia, PA 19107, United StatesOcular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, 840 Walnut Street, Suite 1440, Philadelphia, PA 19107, United StatesOcular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, 840 Walnut Street, Suite 1440, Philadelphia, PA 19107, United StatesOcular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, 840 Walnut Street, Suite 1440, Philadelphia, PA 19107, United StatesOcular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, 840 Walnut Street, Suite 1440, Philadelphia, PA 19107, United States; Corresponding author.Purpose: To investigate features and outcomes of circumscribed choroidal hemangioma by patient age. Methods: Retrospective review of circumscribed choroidal hemangioma from 3/29/1967–6/4/2018 based on age at presentation (≤20 vs. >20–50 vs. >50 years). Results: There were 458 circumscribed choroidal hemangiomas diagnosed at mean age (13 vs. 41 vs. 64 years, p < 0.001). The youngest age group had worse presenting visual acuity (20/400 vs. 20/150 vs. 20/100, p < 0.001), larger tumor basal diameter (13.5 vs. 6.6 vs. 6.2, p < 0.001), greater tumor thickness (5.8 vs. 3.1 vs. 2.9, p < 0.001), closer distance to foveola (0.5 vs. 1.4 vs. 1.2, p = 0.03), and greater extent of subretinal fluid (4 quadrants, 26% vs. 8% vs. 2%, p < 0.001). The youngest patients were less likely to be treated with primary observation (39% vs. 39% vs. 56%) or photodynamic therapy (10% vs. 27% vs. 22%) and more likely to be treated with plaque radiotherapy (26% vs. 6% vs. 3%) or external beam radiotherapy (13% vs. 1% vs. 0%) (p < 0.001). The youngest patients required greater total number of treatments (mean 4 vs. 2 vs. 1, p < 0.001). At mean follow-up (44 vs. 68 vs. 60 months, p = 0.37), the youngest patients had worse visual acuity (20/400 vs. 20/200 vs. 20/100, p = 0.03), but no difference in visual acuity loss of 3 or more Snellen lines (27% vs. 13% vs. 16%, p = 0.55). Conclusion: Younger patients (≤20 years) with circumscribed choroidal hemangioma present with worse visual acuity and larger, more posterior tumors. Future studies are needed to improve early detection and treatment for this subgroup of patients. Keywords: Eye, Choroid, Tumor, Hemangioma, Circumscribed, Agehttp://www.sciencedirect.com/science/article/pii/S1319453419300384 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lauren A. Dalvin Li-Anne S. Lim Michael Chang Sanika Udyaver Mehdi Mazloumi Pornpattana Vichitvejpaisal Grace L. Su Eleni Florakis Arman Mashayekhi Jerry A. Shields Carol L. Shields |
spellingShingle |
Lauren A. Dalvin Li-Anne S. Lim Michael Chang Sanika Udyaver Mehdi Mazloumi Pornpattana Vichitvejpaisal Grace L. Su Eleni Florakis Arman Mashayekhi Jerry A. Shields Carol L. Shields Circumscribed choroidal hemangioma: Clinical features and outcomes by age category in 458 cases Saudi Journal of Ophthalmology |
author_facet |
Lauren A. Dalvin Li-Anne S. Lim Michael Chang Sanika Udyaver Mehdi Mazloumi Pornpattana Vichitvejpaisal Grace L. Su Eleni Florakis Arman Mashayekhi Jerry A. Shields Carol L. Shields |
author_sort |
Lauren A. Dalvin |
title |
Circumscribed choroidal hemangioma: Clinical features and outcomes by age category in 458 cases |
title_short |
Circumscribed choroidal hemangioma: Clinical features and outcomes by age category in 458 cases |
title_full |
Circumscribed choroidal hemangioma: Clinical features and outcomes by age category in 458 cases |
title_fullStr |
Circumscribed choroidal hemangioma: Clinical features and outcomes by age category in 458 cases |
title_full_unstemmed |
Circumscribed choroidal hemangioma: Clinical features and outcomes by age category in 458 cases |
title_sort |
circumscribed choroidal hemangioma: clinical features and outcomes by age category in 458 cases |
publisher |
Wolters Kluwer Medknow Publications |
series |
Saudi Journal of Ophthalmology |
issn |
1319-4534 |
publishDate |
2019-07-01 |
description |
Purpose: To investigate features and outcomes of circumscribed choroidal hemangioma by patient age. Methods: Retrospective review of circumscribed choroidal hemangioma from 3/29/1967–6/4/2018 based on age at presentation (≤20 vs. >20–50 vs. >50 years). Results: There were 458 circumscribed choroidal hemangiomas diagnosed at mean age (13 vs. 41 vs. 64 years, p < 0.001). The youngest age group had worse presenting visual acuity (20/400 vs. 20/150 vs. 20/100, p < 0.001), larger tumor basal diameter (13.5 vs. 6.6 vs. 6.2, p < 0.001), greater tumor thickness (5.8 vs. 3.1 vs. 2.9, p < 0.001), closer distance to foveola (0.5 vs. 1.4 vs. 1.2, p = 0.03), and greater extent of subretinal fluid (4 quadrants, 26% vs. 8% vs. 2%, p < 0.001). The youngest patients were less likely to be treated with primary observation (39% vs. 39% vs. 56%) or photodynamic therapy (10% vs. 27% vs. 22%) and more likely to be treated with plaque radiotherapy (26% vs. 6% vs. 3%) or external beam radiotherapy (13% vs. 1% vs. 0%) (p < 0.001). The youngest patients required greater total number of treatments (mean 4 vs. 2 vs. 1, p < 0.001). At mean follow-up (44 vs. 68 vs. 60 months, p = 0.37), the youngest patients had worse visual acuity (20/400 vs. 20/200 vs. 20/100, p = 0.03), but no difference in visual acuity loss of 3 or more Snellen lines (27% vs. 13% vs. 16%, p = 0.55). Conclusion: Younger patients (≤20 years) with circumscribed choroidal hemangioma present with worse visual acuity and larger, more posterior tumors. Future studies are needed to improve early detection and treatment for this subgroup of patients. Keywords: Eye, Choroid, Tumor, Hemangioma, Circumscribed, Age |
url |
http://www.sciencedirect.com/science/article/pii/S1319453419300384 |
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