Correlation of Indoleamine-2,3-Dioxygenase and Chronic Kidney Disease: A Pilot Study
Objective. To explore the correlation of indoleamine-2,3-dioxygenase (IDO) and chronic kidney disease (CKD). Methods. A total of 154 CKD patients and 42 non-CKD patients were recruited. Patients were grouped into ACR1~ACR3 (<30 mg/g, 30-300 mg/g, and >300 mg/g). Biomarkers in different groups...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2021-01-01
|
Series: | Journal of Immunology Research |
Online Access: | http://dx.doi.org/10.1155/2021/8132569 |
id |
doaj-391e9eb9330b43969a6b499f3df7b65d |
---|---|
record_format |
Article |
spelling |
doaj-391e9eb9330b43969a6b499f3df7b65d2021-02-15T12:52:56ZengHindawi LimitedJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/81325698132569Correlation of Indoleamine-2,3-Dioxygenase and Chronic Kidney Disease: A Pilot StudyBinbin Pan0Feng Zhang1Jian Sun2Dawei Chen3Wenjuan Huang4Hao Zhang5Changchun Cao6Xin Wan7Department of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaObjective. To explore the correlation of indoleamine-2,3-dioxygenase (IDO) and chronic kidney disease (CKD). Methods. A total of 154 CKD patients and 42 non-CKD patients were recruited. Patients were grouped into ACR1~ACR3 (<30 mg/g, 30-300 mg/g, and >300 mg/g). Biomarkers in different groups were compared by ANOVA. Correlation was calculated by Pearson or Spearman analysis and binary logistic regression. The ROC curve was also performed. Results. The levels of albumin, serum creatinine (sCr), and IDO in non-CKD patients were significantly different from those in CKD3-CKD5 stages (p<0.05). IDO was correlated with age, proteinuria, ACR, and eGFR (p<0.01). After adjusting for CKD-related indices, ln(IDO) was an independent risk factor for CKD (3.48, p<0.05). The analysis of ROC curve revealed a best cutoff for IDO was 0.0466 and yielded a sensitivity of 83.8% and a specificity of 75%. Hemoglobin, total protein, and albumin in the ACR1 group were significantly higher than those in the ACR2 and ACR3 groups (p<0.01), while sCr and IDO levels were significantly lower than those in the ACR2 and ACR3 groups (p<0.01 or p<0.05). After adjusting for CKD-related indices, ln(IDO) was still an independent risk factor for ACR (OR=2.7, p<0.05). The analysis of ROC curve revealed a best cutoff for IDO was 0.075 and yielded a sensitivity of 71.9% and a specificity of 72.2%. Conclusion. IDO may be a promising biomarker to predict CKD and assess kidney function.http://dx.doi.org/10.1155/2021/8132569 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Binbin Pan Feng Zhang Jian Sun Dawei Chen Wenjuan Huang Hao Zhang Changchun Cao Xin Wan |
spellingShingle |
Binbin Pan Feng Zhang Jian Sun Dawei Chen Wenjuan Huang Hao Zhang Changchun Cao Xin Wan Correlation of Indoleamine-2,3-Dioxygenase and Chronic Kidney Disease: A Pilot Study Journal of Immunology Research |
author_facet |
Binbin Pan Feng Zhang Jian Sun Dawei Chen Wenjuan Huang Hao Zhang Changchun Cao Xin Wan |
author_sort |
Binbin Pan |
title |
Correlation of Indoleamine-2,3-Dioxygenase and Chronic Kidney Disease: A Pilot Study |
title_short |
Correlation of Indoleamine-2,3-Dioxygenase and Chronic Kidney Disease: A Pilot Study |
title_full |
Correlation of Indoleamine-2,3-Dioxygenase and Chronic Kidney Disease: A Pilot Study |
title_fullStr |
Correlation of Indoleamine-2,3-Dioxygenase and Chronic Kidney Disease: A Pilot Study |
title_full_unstemmed |
Correlation of Indoleamine-2,3-Dioxygenase and Chronic Kidney Disease: A Pilot Study |
title_sort |
correlation of indoleamine-2,3-dioxygenase and chronic kidney disease: a pilot study |
publisher |
Hindawi Limited |
series |
Journal of Immunology Research |
issn |
2314-8861 2314-7156 |
publishDate |
2021-01-01 |
description |
Objective. To explore the correlation of indoleamine-2,3-dioxygenase (IDO) and chronic kidney disease (CKD). Methods. A total of 154 CKD patients and 42 non-CKD patients were recruited. Patients were grouped into ACR1~ACR3 (<30 mg/g, 30-300 mg/g, and >300 mg/g). Biomarkers in different groups were compared by ANOVA. Correlation was calculated by Pearson or Spearman analysis and binary logistic regression. The ROC curve was also performed. Results. The levels of albumin, serum creatinine (sCr), and IDO in non-CKD patients were significantly different from those in CKD3-CKD5 stages (p<0.05). IDO was correlated with age, proteinuria, ACR, and eGFR (p<0.01). After adjusting for CKD-related indices, ln(IDO) was an independent risk factor for CKD (3.48, p<0.05). The analysis of ROC curve revealed a best cutoff for IDO was 0.0466 and yielded a sensitivity of 83.8% and a specificity of 75%. Hemoglobin, total protein, and albumin in the ACR1 group were significantly higher than those in the ACR2 and ACR3 groups (p<0.01), while sCr and IDO levels were significantly lower than those in the ACR2 and ACR3 groups (p<0.01 or p<0.05). After adjusting for CKD-related indices, ln(IDO) was still an independent risk factor for ACR (OR=2.7, p<0.05). The analysis of ROC curve revealed a best cutoff for IDO was 0.075 and yielded a sensitivity of 71.9% and a specificity of 72.2%. Conclusion. IDO may be a promising biomarker to predict CKD and assess kidney function. |
url |
http://dx.doi.org/10.1155/2021/8132569 |
work_keys_str_mv |
AT binbinpan correlationofindoleamine23dioxygenaseandchronickidneydiseaseapilotstudy AT fengzhang correlationofindoleamine23dioxygenaseandchronickidneydiseaseapilotstudy AT jiansun correlationofindoleamine23dioxygenaseandchronickidneydiseaseapilotstudy AT daweichen correlationofindoleamine23dioxygenaseandchronickidneydiseaseapilotstudy AT wenjuanhuang correlationofindoleamine23dioxygenaseandchronickidneydiseaseapilotstudy AT haozhang correlationofindoleamine23dioxygenaseandchronickidneydiseaseapilotstudy AT changchuncao correlationofindoleamine23dioxygenaseandchronickidneydiseaseapilotstudy AT xinwan correlationofindoleamine23dioxygenaseandchronickidneydiseaseapilotstudy |
_version_ |
1714866851359490048 |