Correlation of Indoleamine-2,3-Dioxygenase and Chronic Kidney Disease: A Pilot Study

Objective. To explore the correlation of indoleamine-2,3-dioxygenase (IDO) and chronic kidney disease (CKD). Methods. A total of 154 CKD patients and 42 non-CKD patients were recruited. Patients were grouped into ACR1~ACR3 (<30 mg/g, 30-300 mg/g, and >300 mg/g). Biomarkers in different groups...

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Main Authors: Binbin Pan, Feng Zhang, Jian Sun, Dawei Chen, Wenjuan Huang, Hao Zhang, Changchun Cao, Xin Wan
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2021/8132569
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spelling doaj-391e9eb9330b43969a6b499f3df7b65d2021-02-15T12:52:56ZengHindawi LimitedJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/81325698132569Correlation of Indoleamine-2,3-Dioxygenase and Chronic Kidney Disease: A Pilot StudyBinbin Pan0Feng Zhang1Jian Sun2Dawei Chen3Wenjuan Huang4Hao Zhang5Changchun Cao6Xin Wan7Department of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaObjective. To explore the correlation of indoleamine-2,3-dioxygenase (IDO) and chronic kidney disease (CKD). Methods. A total of 154 CKD patients and 42 non-CKD patients were recruited. Patients were grouped into ACR1~ACR3 (<30 mg/g, 30-300 mg/g, and >300 mg/g). Biomarkers in different groups were compared by ANOVA. Correlation was calculated by Pearson or Spearman analysis and binary logistic regression. The ROC curve was also performed. Results. The levels of albumin, serum creatinine (sCr), and IDO in non-CKD patients were significantly different from those in CKD3-CKD5 stages (p<0.05). IDO was correlated with age, proteinuria, ACR, and eGFR (p<0.01). After adjusting for CKD-related indices, ln(IDO) was an independent risk factor for CKD (3.48, p<0.05). The analysis of ROC curve revealed a best cut­off for IDO was 0.0466 and yielded a sensitivity of 83.8% and a specificity of 75%. Hemoglobin, total protein, and albumin in the ACR1 group were significantly higher than those in the ACR2 and ACR3 groups (p<0.01), while sCr and IDO levels were significantly lower than those in the ACR2 and ACR3 groups (p<0.01 or p<0.05). After adjusting for CKD-related indices, ln(IDO) was still an independent risk factor for ACR (OR=2.7, p<0.05). The analysis of ROC curve revealed a best cut­off for IDO was 0.075 and yielded a sensitivity of 71.9% and a specificity of 72.2%. Conclusion. IDO may be a promising biomarker to predict CKD and assess kidney function.http://dx.doi.org/10.1155/2021/8132569
collection DOAJ
language English
format Article
sources DOAJ
author Binbin Pan
Feng Zhang
Jian Sun
Dawei Chen
Wenjuan Huang
Hao Zhang
Changchun Cao
Xin Wan
spellingShingle Binbin Pan
Feng Zhang
Jian Sun
Dawei Chen
Wenjuan Huang
Hao Zhang
Changchun Cao
Xin Wan
Correlation of Indoleamine-2,3-Dioxygenase and Chronic Kidney Disease: A Pilot Study
Journal of Immunology Research
author_facet Binbin Pan
Feng Zhang
Jian Sun
Dawei Chen
Wenjuan Huang
Hao Zhang
Changchun Cao
Xin Wan
author_sort Binbin Pan
title Correlation of Indoleamine-2,3-Dioxygenase and Chronic Kidney Disease: A Pilot Study
title_short Correlation of Indoleamine-2,3-Dioxygenase and Chronic Kidney Disease: A Pilot Study
title_full Correlation of Indoleamine-2,3-Dioxygenase and Chronic Kidney Disease: A Pilot Study
title_fullStr Correlation of Indoleamine-2,3-Dioxygenase and Chronic Kidney Disease: A Pilot Study
title_full_unstemmed Correlation of Indoleamine-2,3-Dioxygenase and Chronic Kidney Disease: A Pilot Study
title_sort correlation of indoleamine-2,3-dioxygenase and chronic kidney disease: a pilot study
publisher Hindawi Limited
series Journal of Immunology Research
issn 2314-8861
2314-7156
publishDate 2021-01-01
description Objective. To explore the correlation of indoleamine-2,3-dioxygenase (IDO) and chronic kidney disease (CKD). Methods. A total of 154 CKD patients and 42 non-CKD patients were recruited. Patients were grouped into ACR1~ACR3 (<30 mg/g, 30-300 mg/g, and >300 mg/g). Biomarkers in different groups were compared by ANOVA. Correlation was calculated by Pearson or Spearman analysis and binary logistic regression. The ROC curve was also performed. Results. The levels of albumin, serum creatinine (sCr), and IDO in non-CKD patients were significantly different from those in CKD3-CKD5 stages (p<0.05). IDO was correlated with age, proteinuria, ACR, and eGFR (p<0.01). After adjusting for CKD-related indices, ln(IDO) was an independent risk factor for CKD (3.48, p<0.05). The analysis of ROC curve revealed a best cut­off for IDO was 0.0466 and yielded a sensitivity of 83.8% and a specificity of 75%. Hemoglobin, total protein, and albumin in the ACR1 group were significantly higher than those in the ACR2 and ACR3 groups (p<0.01), while sCr and IDO levels were significantly lower than those in the ACR2 and ACR3 groups (p<0.01 or p<0.05). After adjusting for CKD-related indices, ln(IDO) was still an independent risk factor for ACR (OR=2.7, p<0.05). The analysis of ROC curve revealed a best cut­off for IDO was 0.075 and yielded a sensitivity of 71.9% and a specificity of 72.2%. Conclusion. IDO may be a promising biomarker to predict CKD and assess kidney function.
url http://dx.doi.org/10.1155/2021/8132569
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