Deriving the mean excitation energy map from dual-energy and proton computed tomography

Deriving the mean excitation energy map from dual-energy and proton computed tomography

The mean excitation energy, I, is an essential quantity for proton treatment planning. This work investigated the feasibility of extracting the spatial distribution of I by combining two computed tomography (CT) modalities, dual-energy CT and proton CT, which provided the spatial distribution of the...

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Main Authors: Gloria Vilches-Freixas, Catherine Therese Quiñones, Jean Michel Létang, Simon Rit
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Physics and Imaging in Radiation Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S2405631618300125
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spelling doaj-3923b89c09434c0f813011cfcb900b3a2020-11-24T23:38:35ZengElsevierPhysics and Imaging in Radiation Oncology2405-63162018-04-0162024Deriving the mean excitation energy map from dual-energy and proton computed tomographyGloria Vilches-Freixas0Catherine Therese Quiñones1Jean Michel Létang2Simon Rit3Corresponding author at: MAASTRO Clinic, Dr. Tanslaan 12, 6229 ET Maastricht, The Netherlands.; Univ Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, UJM-Saint Étienne, CNRS, INSERM, CREATIS UMR 5220, U1206, Centre Léon Bérard, F-69373 Lyon, FranceUniv Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, UJM-Saint Étienne, CNRS, INSERM, CREATIS UMR 5220, U1206, Centre Léon Bérard, F-69373 Lyon, FranceUniv Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, UJM-Saint Étienne, CNRS, INSERM, CREATIS UMR 5220, U1206, Centre Léon Bérard, F-69373 Lyon, FrancePrincipal corresponding author.; Univ Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, UJM-Saint Étienne, CNRS, INSERM, CREATIS UMR 5220, U1206, Centre Léon Bérard, F-69373 Lyon, FranceThe mean excitation energy, I, is an essential quantity for proton treatment planning. This work investigated the feasibility of extracting the spatial distribution of I by combining two computed tomography (CT) modalities, dual-energy CT and proton CT, which provided the spatial distribution of the relative electron density and the stopping power relative to water, respectively. We provided the analytical derivation of I as well as its uncertainty. Results were validated on simulated X-ray and proton CT images of a digital anthropomorphic phantom. Accuracy was below 15% with a large uncertainty, which demonstrated the potential and limits of the technique. Keywords: Proton CT, Dual-energy CT, Mean excitation energyhttp://www.sciencedirect.com/science/article/pii/S2405631618300125
collection DOAJ
language English
format Article
sources DOAJ
author Gloria Vilches-Freixas
Catherine Therese Quiñones
Jean Michel Létang
Simon Rit
spellingShingle Gloria Vilches-Freixas
Catherine Therese Quiñones
Jean Michel Létang
Simon Rit
Deriving the mean excitation energy map from dual-energy and proton computed tomography
Physics and Imaging in Radiation Oncology
author_facet Gloria Vilches-Freixas
Catherine Therese Quiñones
Jean Michel Létang
Simon Rit
author_sort Gloria Vilches-Freixas
title Deriving the mean excitation energy map from dual-energy and proton computed tomography
title_short Deriving the mean excitation energy map from dual-energy and proton computed tomography
title_full Deriving the mean excitation energy map from dual-energy and proton computed tomography
title_fullStr Deriving the mean excitation energy map from dual-energy and proton computed tomography
title_full_unstemmed Deriving the mean excitation energy map from dual-energy and proton computed tomography
title_sort deriving the mean excitation energy map from dual-energy and proton computed tomography
publisher Elsevier
series Physics and Imaging in Radiation Oncology
issn 2405-6316
publishDate 2018-04-01
description The mean excitation energy, I, is an essential quantity for proton treatment planning. This work investigated the feasibility of extracting the spatial distribution of I by combining two computed tomography (CT) modalities, dual-energy CT and proton CT, which provided the spatial distribution of the relative electron density and the stopping power relative to water, respectively. We provided the analytical derivation of I as well as its uncertainty. Results were validated on simulated X-ray and proton CT images of a digital anthropomorphic phantom. Accuracy was below 15% with a large uncertainty, which demonstrated the potential and limits of the technique. Keywords: Proton CT, Dual-energy CT, Mean excitation energy
url http://www.sciencedirect.com/science/article/pii/S2405631618300125
work_keys_str_mv AT gloriavilchesfreixas derivingthemeanexcitationenergymapfromdualenergyandprotoncomputedtomography
AT catherinetheresequinones derivingthemeanexcitationenergymapfromdualenergyandprotoncomputedtomography
AT jeanmichelletang derivingthemeanexcitationenergymapfromdualenergyandprotoncomputedtomography
AT simonrit derivingthemeanexcitationenergymapfromdualenergyandprotoncomputedtomography
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