Fructooligosaccharides supplementation mitigated chronic stress-induced intestinal barrier impairment and neuroinflammation in mice

Recently, accumulating evidence has suggested that gut microbiota is involved in modulating brain function and behavior through the gut-brain axis. Manipulation of gut microbiota by functional foods, such as prebiotics and probiotics, might improve mental health in stress-related psychiatric disorde...

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Main Authors:	Yuanfang Zhang, Ping Wang, Chuan Xia, Zhengchun Wu, Zhihong Zhong, Ye Xu, Yiliang Zeng, Hongrong Liu, Rushi Liu, Minjing Liao
Format:	Article
Language:	English
Published:	Elsevier 2020-09-01
Series:	Journal of Functional Foods
Subjects:	Chronic stress Depression Gut microbiota Prebiotic Fructooligosaccharides Neuroinflammation
Online Access:	http://www.sciencedirect.com/science/article/pii/S175646462030284X

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spelling	doaj-3926ef5a55e24fa2981172c3ac487d402021-04-30T07:19:15ZengElsevierJournal of Functional Foods1756-46462020-09-0172104060Fructooligosaccharides supplementation mitigated chronic stress-induced intestinal barrier impairment and neuroinflammation in miceYuanfang Zhang0Ping Wang1Chuan Xia2Zhengchun Wu3Zhihong Zhong4Ye Xu5Yiliang Zeng6Hongrong Liu7Rushi Liu8Minjing Liao9Department of Medical Laboratory, School of Medicine, Hunan Normal University, Changsha 410013, China; Immunodiagnostic Reagents Engineering Research Center of Hunan Province, Hunan Normal University, Changsha 410013, ChinaDepartment of Medical Laboratory, School of Medicine, Hunan Normal University, Changsha 410013, China; Immunodiagnostic Reagents Engineering Research Center of Hunan Province, Hunan Normal University, Changsha 410013, ChinaDepartment of Medical Laboratory, School of Medicine, Hunan Normal University, Changsha 410013, China; Immunodiagnostic Reagents Engineering Research Center of Hunan Province, Hunan Normal University, Changsha 410013, ChinaDepartment of General Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, ChinaDepartment of Medical Laboratory, School of Medicine, Hunan Normal University, Changsha 410013, China; Immunodiagnostic Reagents Engineering Research Center of Hunan Province, Hunan Normal University, Changsha 410013, ChinaDepartment of Medical Laboratory, School of Medicine, Hunan Normal University, Changsha 410013, China; Immunodiagnostic Reagents Engineering Research Center of Hunan Province, Hunan Normal University, Changsha 410013, ChinaShaoshan Changbaitong Biotechnology Co., Ltd., Shaoshan 411100, ChinaImmunodiagnostic Reagents Engineering Research Center of Hunan Province, Hunan Normal University, Changsha 410013, ChinaDepartment of Medical Laboratory, School of Medicine, Hunan Normal University, Changsha 410013, China; Immunodiagnostic Reagents Engineering Research Center of Hunan Province, Hunan Normal University, Changsha 410013, China; Changsha Hospital Affiliated to Hunan Normal University, Changsha 410081, China; Corresponding authors at: Department of Medical Laboratory, School of Medicine, Hunan Normal University, Changsha 410013, China.Department of Medical Laboratory, School of Medicine, Hunan Normal University, Changsha 410013, China; Immunodiagnostic Reagents Engineering Research Center of Hunan Province, Hunan Normal University, Changsha 410013, China; Corresponding authors at: Department of Medical Laboratory, School of Medicine, Hunan Normal University, Changsha 410013, China.Recently, accumulating evidence has suggested that gut microbiota is involved in modulating brain function and behavior through the gut-brain axis. Manipulation of gut microbiota by functional foods, such as prebiotics and probiotics, might improve mental health in stress-related psychiatric disorders. In present study, we found that supplementation of fructooligosaccharides could improve the depression-like behaviors and had a significant effect on the composition of gut flora in chronic stress mice. FOS treatment exhibited no effects on the elevated level of serum corticosterone in chronic stress mice, but significantly reversed the alterations of colonic tight junction proteins (Claudin1, Occludin, ZO-1) and reduced the pro-inflammatory cytokines (TNF-α, IL-6) in colon and brain. Thus, FOS might exert an anti-depressant effect via the prevention of intestinal barrier impairment and neuroinflammation induced by chronic stress.http://www.sciencedirect.com/science/article/pii/S175646462030284XChronic stressDepressionGut microbiotaPrebioticFructooligosaccharidesNeuroinflammation
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yuanfang Zhang Ping Wang Chuan Xia Zhengchun Wu Zhihong Zhong Ye Xu Yiliang Zeng Hongrong Liu Rushi Liu Minjing Liao
spellingShingle	Yuanfang Zhang Ping Wang Chuan Xia Zhengchun Wu Zhihong Zhong Ye Xu Yiliang Zeng Hongrong Liu Rushi Liu Minjing Liao Fructooligosaccharides supplementation mitigated chronic stress-induced intestinal barrier impairment and neuroinflammation in mice Journal of Functional Foods Chronic stress Depression Gut microbiota Prebiotic Fructooligosaccharides Neuroinflammation
author_facet	Yuanfang Zhang Ping Wang Chuan Xia Zhengchun Wu Zhihong Zhong Ye Xu Yiliang Zeng Hongrong Liu Rushi Liu Minjing Liao
author_sort	Yuanfang Zhang
title	Fructooligosaccharides supplementation mitigated chronic stress-induced intestinal barrier impairment and neuroinflammation in mice
title_short	Fructooligosaccharides supplementation mitigated chronic stress-induced intestinal barrier impairment and neuroinflammation in mice
title_full	Fructooligosaccharides supplementation mitigated chronic stress-induced intestinal barrier impairment and neuroinflammation in mice
title_fullStr	Fructooligosaccharides supplementation mitigated chronic stress-induced intestinal barrier impairment and neuroinflammation in mice
title_full_unstemmed	Fructooligosaccharides supplementation mitigated chronic stress-induced intestinal barrier impairment and neuroinflammation in mice
title_sort	fructooligosaccharides supplementation mitigated chronic stress-induced intestinal barrier impairment and neuroinflammation in mice
publisher	Elsevier
series	Journal of Functional Foods
issn	1756-4646
publishDate	2020-09-01
description	Recently, accumulating evidence has suggested that gut microbiota is involved in modulating brain function and behavior through the gut-brain axis. Manipulation of gut microbiota by functional foods, such as prebiotics and probiotics, might improve mental health in stress-related psychiatric disorders. In present study, we found that supplementation of fructooligosaccharides could improve the depression-like behaviors and had a significant effect on the composition of gut flora in chronic stress mice. FOS treatment exhibited no effects on the elevated level of serum corticosterone in chronic stress mice, but significantly reversed the alterations of colonic tight junction proteins (Claudin1, Occludin, ZO-1) and reduced the pro-inflammatory cytokines (TNF-α, IL-6) in colon and brain. Thus, FOS might exert an anti-depressant effect via the prevention of intestinal barrier impairment and neuroinflammation induced by chronic stress.
topic	Chronic stress Depression Gut microbiota Prebiotic Fructooligosaccharides Neuroinflammation
url	http://www.sciencedirect.com/science/article/pii/S175646462030284X
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Fructooligosaccharides supplementation mitigated chronic stress-induced intestinal barrier impairment and neuroinflammation in mice

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