Differentiation of Acute Q Fever from Other Infections in Patients Presenting to Hospitals, the Netherlands
Differentiating acute Q fever from infections caused by other pathogens is essential. We conducted a retrospective case–control study to evaluate differences in clinical signs, symptoms, and outcomes for 82 patients with acute Q fever and 52 control patients who had pneumonia, fever and lower respir...
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2015-08-01
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doaj-392b3235643f4e598a592f8b5a3dd9d92020-11-25T00:31:04ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592015-08-012181348135610.3201/eid2108.140196Differentiation of Acute Q Fever from Other Infections in Patients Presenting to Hospitals, the NetherlandsStephan P. KeijmelElmer KrijgerCorine E. DelsingTom SprongMarrigje H. Nabuurs-FranssenChantal P. Bleeker-RoversDifferentiating acute Q fever from infections caused by other pathogens is essential. We conducted a retrospective case–control study to evaluate differences in clinical signs, symptoms, and outcomes for 82 patients with acute Q fever and 52 control patients who had pneumonia, fever and lower respiratory tract symptoms, or fever and hepatitis, but had negative serologic results for Q fever. Patients with acute Q fever were younger and had higher C-reactive protein levels but lower leukocyte counts. However, a large overlap was found. In patients with an indication for prophylaxis, chronic Q fever did not develop after patients received prophylaxis but did develop in 50% of patients who did not receive prophylaxis. Differentiating acute Q fever from other respiratory infections, fever, or hepatitis is not possible without serologic testing or PCR. If risk factors for chronic Q fever are present, prophylactic treatment is advised.https://wwwnc.cdc.gov/eid/article/21/8/14-0196_articleQ feveracute Q feverchronic Q fevercase–control studyclinical practiceCoxiella burnetii |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stephan P. Keijmel Elmer Krijger Corine E. Delsing Tom Sprong Marrigje H. Nabuurs-Franssen Chantal P. Bleeker-Rovers |
spellingShingle |
Stephan P. Keijmel Elmer Krijger Corine E. Delsing Tom Sprong Marrigje H. Nabuurs-Franssen Chantal P. Bleeker-Rovers Differentiation of Acute Q Fever from Other Infections in Patients Presenting to Hospitals, the Netherlands Emerging Infectious Diseases Q fever acute Q fever chronic Q fever case–control study clinical practice Coxiella burnetii |
author_facet |
Stephan P. Keijmel Elmer Krijger Corine E. Delsing Tom Sprong Marrigje H. Nabuurs-Franssen Chantal P. Bleeker-Rovers |
author_sort |
Stephan P. Keijmel |
title |
Differentiation of Acute Q Fever from Other Infections in Patients Presenting to Hospitals, the Netherlands |
title_short |
Differentiation of Acute Q Fever from Other Infections in Patients Presenting to Hospitals, the Netherlands |
title_full |
Differentiation of Acute Q Fever from Other Infections in Patients Presenting to Hospitals, the Netherlands |
title_fullStr |
Differentiation of Acute Q Fever from Other Infections in Patients Presenting to Hospitals, the Netherlands |
title_full_unstemmed |
Differentiation of Acute Q Fever from Other Infections in Patients Presenting to Hospitals, the Netherlands |
title_sort |
differentiation of acute q fever from other infections in patients presenting to hospitals, the netherlands |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2015-08-01 |
description |
Differentiating acute Q fever from infections caused by other pathogens is essential. We conducted a retrospective case–control study to evaluate differences in clinical signs, symptoms, and outcomes for 82 patients with acute Q fever and 52 control patients who had pneumonia, fever and lower respiratory tract symptoms, or fever and hepatitis, but had negative serologic results for Q fever. Patients with acute Q fever were younger and had higher C-reactive protein levels but lower leukocyte counts. However, a large overlap was found. In patients with an indication for prophylaxis, chronic Q fever did not develop after patients received prophylaxis but did develop in 50% of patients who did not receive prophylaxis. Differentiating acute Q fever from other respiratory infections, fever, or hepatitis is not possible without serologic testing or PCR. If risk factors for chronic Q fever are present, prophylactic treatment is advised. |
topic |
Q fever acute Q fever chronic Q fever case–control study clinical practice Coxiella burnetii |
url |
https://wwwnc.cdc.gov/eid/article/21/8/14-0196_article |
work_keys_str_mv |
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