p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis

p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis

Both p16Ink4a and p21Cip1/Waf1 are known oncosuppressors and have a role in senescence. Here, the authors show a pro-tumorigenic role for these two proteins: high expression in myeloid-derived suppressor cells stimulates their chemotactic function, favouring tumour progression.

Bibliographic Details
Main Authors: Atsushi Okuma, Aki Hanyu, Sugiko Watanabe, Eiji Hara
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02281-x
id doaj-392be485396f4baba3edd082b4c5ecbf
record_format Article
spelling doaj-392be485396f4baba3edd082b4c5ecbf2021-05-11T07:52:37ZengNature Publishing GroupNature Communications2041-17232017-12-018111310.1038/s41467-017-02281-xp16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxisAtsushi Okuma0Aki Hanyu1Sugiko Watanabe2Eiji Hara3Department of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University, 3-1 YamadaokaThe Cancer Institute, Japanese Foundation for Cancer ResearchDepartment of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University, 3-1 YamadaokaDepartment of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University, 3-1 YamadaokaBoth p16Ink4a and p21Cip1/Waf1 are known oncosuppressors and have a role in senescence. Here, the authors show a pro-tumorigenic role for these two proteins: high expression in myeloid-derived suppressor cells stimulates their chemotactic function, favouring tumour progression.https://doi.org/10.1038/s41467-017-02281-x
collection DOAJ
language English
format Article
sources DOAJ
author Atsushi Okuma
Aki Hanyu
Sugiko Watanabe
Eiji Hara
spellingShingle Atsushi Okuma
Aki Hanyu
Sugiko Watanabe
Eiji Hara
p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
Nature Communications
author_facet Atsushi Okuma
Aki Hanyu
Sugiko Watanabe
Eiji Hara
author_sort Atsushi Okuma
title p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
title_short p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
title_full p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
title_fullStr p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
title_full_unstemmed p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
title_sort p16ink4a and p21cip1/waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-12-01
description Both p16Ink4a and p21Cip1/Waf1 are known oncosuppressors and have a role in senescence. Here, the authors show a pro-tumorigenic role for these two proteins: high expression in myeloid-derived suppressor cells stimulates their chemotactic function, favouring tumour progression.
url https://doi.org/10.1038/s41467-017-02281-x
work_keys_str_mv AT atsushiokuma p16ink4aandp21cip1waf1promotetumourgrowthbyenhancingmyeloidderivedsuppressorcellschemotaxis
AT akihanyu p16ink4aandp21cip1waf1promotetumourgrowthbyenhancingmyeloidderivedsuppressorcellschemotaxis
AT sugikowatanabe p16ink4aandp21cip1waf1promotetumourgrowthbyenhancingmyeloidderivedsuppressorcellschemotaxis
AT eijihara p16ink4aandp21cip1waf1promotetumourgrowthbyenhancingmyeloidderivedsuppressorcellschemotaxis
_version_ 1721451376660185088

Similar Items