α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb
Abstract Alpha-synuclein inclusions, the hallmarks of synucleinopathies, are suggested to spread along neuronal connections in a stereotypical pattern in the brains of patients. Ample evidence now supports that pathological forms of alpha-synuclein propagate in cell culture models and in vivo in a p...
Main Authors: | Nolwen L. Rey, Luc Bousset, Sonia George, Zachary Madaj, Lindsay Meyerdirk, Emily Schulz, Jennifer A. Steiner, Ronald Melki, Patrik Brundin |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-12-01
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Series: | Acta Neuropathologica Communications |
Subjects: | |
Online Access: | https://doi.org/10.1186/s40478-019-0859-3 |
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