Nefopam downregulates autophagy and c-Jun N-terminal kinase activity in the regulation of neuropathic pain development following spinal nerve ligation

Nefopam downregulates autophagy and c-Jun N-terminal kinase activity in the regulation of neuropathic pain development following spinal nerve ligation

Abstract Background Neurodegeneration is associated with changes in basal cellular function due to the dysregulation of autophagy. A recent study introduced the involvement of autophagy during spinal nerve ligation (SNL). Nefopam has shown potential for reducing neuropathic pain, but the underlying...

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Bibliographic Details
Main Authors: Seon-Hee Oh, Myung Ha Yoon, Kyung Joon Lim, Byung Sik Yu, In Gook Jee, Ki Tae Jung
Format: Article
Language:English
Published: BMC 2018-07-01
Series:BMC Anesthesiology
Subjects:
Autophagy
JNK
Nefopam
Neuropathic pain
Rat
Online Access:http://link.springer.com/article/10.1186/s12871-018-0559-8

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http://link.springer.com/article/10.1186/s12871-018-0559-8

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