Antibacterial Activity of Bacterial Cellulose Loaded with Bacitracin and Amoxicillin: In Vitro Studies

Antibacterial Activity of Bacterial Cellulose Loaded with Bacitracin and Amoxicillin: In Vitro Studies

The use of bacterial cellulose (BC) in skin wound treatment is very attractive due to its unique characteristics. These dressings’ wet environment is an important feature that ensures efficient healing. In order to enhance the antimicrobial performances, bacterial-cellulose dressings were loaded wit...

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Main Authors: Georgiana-Mădălina Lemnaru (Popa), Roxana Doina Truşcă, Cornelia-Ioana Ilie, Roxana Elena Țiplea, Denisa Ficai, Ovidiu Oprea, Anicuța Stoica-Guzun, Anton Ficai, Lia-Mara Dițu
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
bacterial cellulose
skin wounds
antimicrobial effect
drug delivery
dressings
Online Access:https://www.mdpi.com/1420-3049/25/18/4069
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spelling doaj-3932483b9e704960a6a2249861d4a29d2020-11-25T03:43:32ZengMDPI AGMolecules1420-30492020-09-01254069406910.3390/molecules25184069Antibacterial Activity of Bacterial Cellulose Loaded with Bacitracin and Amoxicillin: In Vitro StudiesGeorgiana-Mădălina Lemnaru (Popa)0Roxana Doina Truşcă1Cornelia-Ioana Ilie2Roxana Elena Țiplea3Denisa Ficai4Ovidiu Oprea5Anicuța Stoica-Guzun6Anton Ficai7Lia-Mara Dițu8National Centre for Micro and Nanomaterials and National Centre for Food Safety, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, RomaniaNational Centre for Micro and Nanomaterials and National Centre for Food Safety, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, RomaniaNational Centre for Micro and Nanomaterials and National Centre for Food Safety, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, RomaniaNational Centre for Micro and Nanomaterials and National Centre for Food Safety, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, RomaniaNational Centre for Micro and Nanomaterials and National Centre for Food Safety, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, RomaniaNational Centre for Micro and Nanomaterials and National Centre for Food Safety, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, RomaniaNational Centre for Micro and Nanomaterials and National Centre for Food Safety, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, RomaniaNational Centre for Micro and Nanomaterials and National Centre for Food Safety, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, RomaniaFaculty of Biology, University of Bucharest, 1-3 Aleea Portocalelor, 060101 Bucharest, RomaniaThe use of bacterial cellulose (BC) in skin wound treatment is very attractive due to its unique characteristics. These dressings’ wet environment is an important feature that ensures efficient healing. In order to enhance the antimicrobial performances, bacterial-cellulose dressings were loaded with amoxicillin and bacitracin as antibacterial agents. Infrared characterization and thermal analysis confirmed bacterial-cellulose binding to the drug. Hydration capacity showed good hydrophilicity, an efficient dressing’s property. The results confirmed the drugs’ presence in the bacterial-cellulose dressing’s structure as well as the antimicrobial efficiency against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>. The antimicrobial assessments were evaluated by contacting these dressings with the above-mentioned bacterial strains and evaluating the growth inhibition of these microorganisms.https://www.mdpi.com/1420-3049/25/18/4069bacterial celluloseskin woundsantimicrobial effectdrug deliverydressings
collection DOAJ
language English
format Article
sources DOAJ
author Georgiana-Mădălina Lemnaru (Popa)
Roxana Doina Truşcă
Cornelia-Ioana Ilie
Roxana Elena Țiplea
Denisa Ficai
Ovidiu Oprea
Anicuța Stoica-Guzun
Anton Ficai
Lia-Mara Dițu
spellingShingle Georgiana-Mădălina Lemnaru (Popa)
Roxana Doina Truşcă
Cornelia-Ioana Ilie
Roxana Elena Țiplea
Denisa Ficai
Ovidiu Oprea
Anicuța Stoica-Guzun
Anton Ficai
Lia-Mara Dițu
Antibacterial Activity of Bacterial Cellulose Loaded with Bacitracin and Amoxicillin: In Vitro Studies
Molecules
bacterial cellulose
skin wounds
antimicrobial effect
drug delivery
dressings
author_facet Georgiana-Mădălina Lemnaru (Popa)
Roxana Doina Truşcă
Cornelia-Ioana Ilie
Roxana Elena Țiplea
Denisa Ficai
Ovidiu Oprea
Anicuța Stoica-Guzun
Anton Ficai
Lia-Mara Dițu
author_sort Georgiana-Mădălina Lemnaru (Popa)
title Antibacterial Activity of Bacterial Cellulose Loaded with Bacitracin and Amoxicillin: In Vitro Studies
title_short Antibacterial Activity of Bacterial Cellulose Loaded with Bacitracin and Amoxicillin: In Vitro Studies
title_full Antibacterial Activity of Bacterial Cellulose Loaded with Bacitracin and Amoxicillin: In Vitro Studies
title_fullStr Antibacterial Activity of Bacterial Cellulose Loaded with Bacitracin and Amoxicillin: In Vitro Studies
title_full_unstemmed Antibacterial Activity of Bacterial Cellulose Loaded with Bacitracin and Amoxicillin: In Vitro Studies
title_sort antibacterial activity of bacterial cellulose loaded with bacitracin and amoxicillin: in vitro studies
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2020-09-01
description The use of bacterial cellulose (BC) in skin wound treatment is very attractive due to its unique characteristics. These dressings’ wet environment is an important feature that ensures efficient healing. In order to enhance the antimicrobial performances, bacterial-cellulose dressings were loaded with amoxicillin and bacitracin as antibacterial agents. Infrared characterization and thermal analysis confirmed bacterial-cellulose binding to the drug. Hydration capacity showed good hydrophilicity, an efficient dressing’s property. The results confirmed the drugs’ presence in the bacterial-cellulose dressing’s structure as well as the antimicrobial efficiency against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>. The antimicrobial assessments were evaluated by contacting these dressings with the above-mentioned bacterial strains and evaluating the growth inhibition of these microorganisms.
topic bacterial cellulose
skin wounds
antimicrobial effect
drug delivery
dressings
url https://www.mdpi.com/1420-3049/25/18/4069
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AT corneliaioanailie antibacterialactivityofbacterialcelluloseloadedwithbacitracinandamoxicillininvitrostudies
AT roxanaelenatiplea antibacterialactivityofbacterialcelluloseloadedwithbacitracinandamoxicillininvitrostudies
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