Racial/ethnic disparities in renal cell carcinoma: Increased risk of early‐onset and variation in histologic subtypes
Abstract Background Racial/ethnic minority groups have a higher burden of renal cell carcinoma (RCC), but RCC among Hispanic Americans (HAs) and American Indians and Alaska Natives (AIs/ANs) are clinically not well characterized. We explored variations in age at diagnosis and frequencies of RCC hist...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2019-11-01
|
Series: | Cancer Medicine |
Subjects: | |
Online Access: | https://doi.org/10.1002/cam4.2552 |
id |
doaj-393bf652edd6439e9467745e8b118694 |
---|---|
record_format |
Article |
spelling |
doaj-393bf652edd6439e9467745e8b1186942020-11-25T02:07:02ZengWileyCancer Medicine2045-76342019-11-018156780678810.1002/cam4.2552Racial/ethnic disparities in renal cell carcinoma: Increased risk of early‐onset and variation in histologic subtypesKen Batai0Alfredo Harb‐De la Rosa1Jiping Zeng2Juan J. Chipollini3Francine C. Gachupin4Benjamin R. Lee5Department of Urology University of Arizona Tucson ArizonaDepartment of Urology University of Arizona Tucson ArizonaDepartment of Urology University of Arizona Tucson ArizonaDepartment of Urology University of Arizona Tucson ArizonaDepartment of Family and Community Medicine University of Arizona Tucson ArizonaDepartment of Urology University of Arizona Tucson ArizonaAbstract Background Racial/ethnic minority groups have a higher burden of renal cell carcinoma (RCC), but RCC among Hispanic Americans (HAs) and American Indians and Alaska Natives (AIs/ANs) are clinically not well characterized. We explored variations in age at diagnosis and frequencies of RCC histologic subtypes across racial/ethnic groups and Hispanic subgroups using National Cancer Database (NCDB) and Arizona Cancer Registry Data. Methods Adult RCC cases with known race/ethnicity were included. Logistic regression analysis was performed to estimate odds and 95% confidence interval (CI) of early‐onset (age at diagnosis <50 years) and diagnosis with clear cell RCC (ccRCC) or papillary RCC. Results A total of 405 073 RCC cases from NCDB and 9751 cases from ACR were identified and included. In both datasets, patients from racial/ethnic minority groups had a younger age at diagnosis than non‐Hispanic White (NHW) patients. In the NCDB, AIs/ANs had twofold increased odds (OR, 2.21; 95% CI, 1.88‐2.59) of early‐onset RCC compared with NHWs. HAs also had twofold increased odds of early‐onset RCC (OR, 2.14; 95% CI, 1.79‐2.55) in the ACR. In NCDB, ccRCC was more prevalent in AIs (86.3%) and Mexican Americans (83.5%) than NHWs (72.5%). AIs/ANs had twofold increased odds of diagnosis with ccRCC (OR, 2.18; 95% CI, 1.85‐2.58) in the NCDB, but the association was stronger in the ACR (OR, 2.83; 95% CI, 2.08‐3.85). Similarly, Mexican Americans had significantly increased odds of diagnosis with ccRCC (OR, 2.00; 95% CI, 1.78‐2.23) in the NCDB. Conclusions This study reports younger age at diagnosis and higher frequencies of ccRCC histologic subtype in AIs/ANs and Hispanic subgroups. These variations across racial/ethnic groups and Hispanic subgroups may have potential clinical implications.https://doi.org/10.1002/cam4.2552American Indiansearly onsethealth disparitiesHispanic Americansrenal cell carcinoma subtypes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ken Batai Alfredo Harb‐De la Rosa Jiping Zeng Juan J. Chipollini Francine C. Gachupin Benjamin R. Lee |
spellingShingle |
Ken Batai Alfredo Harb‐De la Rosa Jiping Zeng Juan J. Chipollini Francine C. Gachupin Benjamin R. Lee Racial/ethnic disparities in renal cell carcinoma: Increased risk of early‐onset and variation in histologic subtypes Cancer Medicine American Indians early onset health disparities Hispanic Americans renal cell carcinoma subtypes |
author_facet |
Ken Batai Alfredo Harb‐De la Rosa Jiping Zeng Juan J. Chipollini Francine C. Gachupin Benjamin R. Lee |
author_sort |
Ken Batai |
title |
Racial/ethnic disparities in renal cell carcinoma: Increased risk of early‐onset and variation in histologic subtypes |
title_short |
Racial/ethnic disparities in renal cell carcinoma: Increased risk of early‐onset and variation in histologic subtypes |
title_full |
Racial/ethnic disparities in renal cell carcinoma: Increased risk of early‐onset and variation in histologic subtypes |
title_fullStr |
Racial/ethnic disparities in renal cell carcinoma: Increased risk of early‐onset and variation in histologic subtypes |
title_full_unstemmed |
Racial/ethnic disparities in renal cell carcinoma: Increased risk of early‐onset and variation in histologic subtypes |
title_sort |
racial/ethnic disparities in renal cell carcinoma: increased risk of early‐onset and variation in histologic subtypes |
publisher |
Wiley |
series |
Cancer Medicine |
issn |
2045-7634 |
publishDate |
2019-11-01 |
description |
Abstract Background Racial/ethnic minority groups have a higher burden of renal cell carcinoma (RCC), but RCC among Hispanic Americans (HAs) and American Indians and Alaska Natives (AIs/ANs) are clinically not well characterized. We explored variations in age at diagnosis and frequencies of RCC histologic subtypes across racial/ethnic groups and Hispanic subgroups using National Cancer Database (NCDB) and Arizona Cancer Registry Data. Methods Adult RCC cases with known race/ethnicity were included. Logistic regression analysis was performed to estimate odds and 95% confidence interval (CI) of early‐onset (age at diagnosis <50 years) and diagnosis with clear cell RCC (ccRCC) or papillary RCC. Results A total of 405 073 RCC cases from NCDB and 9751 cases from ACR were identified and included. In both datasets, patients from racial/ethnic minority groups had a younger age at diagnosis than non‐Hispanic White (NHW) patients. In the NCDB, AIs/ANs had twofold increased odds (OR, 2.21; 95% CI, 1.88‐2.59) of early‐onset RCC compared with NHWs. HAs also had twofold increased odds of early‐onset RCC (OR, 2.14; 95% CI, 1.79‐2.55) in the ACR. In NCDB, ccRCC was more prevalent in AIs (86.3%) and Mexican Americans (83.5%) than NHWs (72.5%). AIs/ANs had twofold increased odds of diagnosis with ccRCC (OR, 2.18; 95% CI, 1.85‐2.58) in the NCDB, but the association was stronger in the ACR (OR, 2.83; 95% CI, 2.08‐3.85). Similarly, Mexican Americans had significantly increased odds of diagnosis with ccRCC (OR, 2.00; 95% CI, 1.78‐2.23) in the NCDB. Conclusions This study reports younger age at diagnosis and higher frequencies of ccRCC histologic subtype in AIs/ANs and Hispanic subgroups. These variations across racial/ethnic groups and Hispanic subgroups may have potential clinical implications. |
topic |
American Indians early onset health disparities Hispanic Americans renal cell carcinoma subtypes |
url |
https://doi.org/10.1002/cam4.2552 |
work_keys_str_mv |
AT kenbatai racialethnicdisparitiesinrenalcellcarcinomaincreasedriskofearlyonsetandvariationinhistologicsubtypes AT alfredoharbdelarosa racialethnicdisparitiesinrenalcellcarcinomaincreasedriskofearlyonsetandvariationinhistologicsubtypes AT jipingzeng racialethnicdisparitiesinrenalcellcarcinomaincreasedriskofearlyonsetandvariationinhistologicsubtypes AT juanjchipollini racialethnicdisparitiesinrenalcellcarcinomaincreasedriskofearlyonsetandvariationinhistologicsubtypes AT francinecgachupin racialethnicdisparitiesinrenalcellcarcinomaincreasedriskofearlyonsetandvariationinhistologicsubtypes AT benjaminrlee racialethnicdisparitiesinrenalcellcarcinomaincreasedriskofearlyonsetandvariationinhistologicsubtypes |
_version_ |
1724931543713972224 |