Thrombocytopenia in severe iron deficiency anemia in children
Abstract Aim Iron deficiency anemia (IDA) is common in the pediatric population and often accompanied by mild thrombocytosis, but rarely profound thrombocytopenia is seen. We describe the data of children with IDA and thrombocytopenia in two centers and discuss the published data in the literature....
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doaj-3943b74648fb4ca1bcea2cc6853edde42021-09-29T06:32:35ZengWileyHealth Science Reports2398-88352021-09-0143n/an/a10.1002/hsr2.351Thrombocytopenia in severe iron deficiency anemia in childrenMachiel van den Akker0Laura Chielens1Lisa Lopes2Jaques van Heerden3Mahmoud Zaqout4Jutte van der Werf Ten Bosch5Department of Pediatrics ZNA Queen Paola Children's Hospital Antwerp BelgiumFaculty of Medicine and Health Sciences University of Brussels Jette BelgiumFaculty of Medicine and Health Sciences University of Antwerp Antwerp BelgiumPediatric Hematology/Oncology Unit, Queen Mathilde Mother and Child Center Antwerp University Hospital Edegem BelgiumDepartment of Pediatrics ZNA Queen Paola Children's Hospital Antwerp BelgiumDepartment of Pediatrics ZNA Queen Paola Children's Hospital Antwerp BelgiumAbstract Aim Iron deficiency anemia (IDA) is common in the pediatric population and often accompanied by mild thrombocytosis, but rarely profound thrombocytopenia is seen. We describe the data of children with IDA and thrombocytopenia in two centers and discuss the published data in the literature. Methods In this retrospective case series, the medical records of patients under the age of 19 years old diagnosed with IDA in two tertiary medical centers over the last 10 years, were reviewed. The data were collected and compared to the data published in the medical literature. Results All the patients presented with severe IDA and thrombocytopenia improved with iron treatment. Although none of the patients had signs of major bleeding, the thrombocytopenia could mostly be classified as severe (platelet count <50×10E9/L). Due to the severity of the anemia, in about half of the cases, a red blood cell transfusion was given. The peak of the platelet count was seen in the first month after the start of iron treatment. In eight cases of children with IDA, the thrombocytopenia appeared after the supplementation of iron was started. Conclusion Clinically stable children with severe IDA and thrombocytopenia, where other causes are very unlikely, warrant an empiric monotherapy with iron to prevent unnecessary investigations and treatments.https://doi.org/10.1002/hsr2.351childrenerythropoietiniron deficiency anemiathrombocytopeniathrombocytosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Machiel van den Akker Laura Chielens Lisa Lopes Jaques van Heerden Mahmoud Zaqout Jutte van der Werf Ten Bosch |
spellingShingle |
Machiel van den Akker Laura Chielens Lisa Lopes Jaques van Heerden Mahmoud Zaqout Jutte van der Werf Ten Bosch Thrombocytopenia in severe iron deficiency anemia in children Health Science Reports children erythropoietin iron deficiency anemia thrombocytopenia thrombocytosis |
author_facet |
Machiel van den Akker Laura Chielens Lisa Lopes Jaques van Heerden Mahmoud Zaqout Jutte van der Werf Ten Bosch |
author_sort |
Machiel van den Akker |
title |
Thrombocytopenia in severe iron deficiency anemia in children |
title_short |
Thrombocytopenia in severe iron deficiency anemia in children |
title_full |
Thrombocytopenia in severe iron deficiency anemia in children |
title_fullStr |
Thrombocytopenia in severe iron deficiency anemia in children |
title_full_unstemmed |
Thrombocytopenia in severe iron deficiency anemia in children |
title_sort |
thrombocytopenia in severe iron deficiency anemia in children |
publisher |
Wiley |
series |
Health Science Reports |
issn |
2398-8835 |
publishDate |
2021-09-01 |
description |
Abstract Aim Iron deficiency anemia (IDA) is common in the pediatric population and often accompanied by mild thrombocytosis, but rarely profound thrombocytopenia is seen. We describe the data of children with IDA and thrombocytopenia in two centers and discuss the published data in the literature. Methods In this retrospective case series, the medical records of patients under the age of 19 years old diagnosed with IDA in two tertiary medical centers over the last 10 years, were reviewed. The data were collected and compared to the data published in the medical literature. Results All the patients presented with severe IDA and thrombocytopenia improved with iron treatment. Although none of the patients had signs of major bleeding, the thrombocytopenia could mostly be classified as severe (platelet count <50×10E9/L). Due to the severity of the anemia, in about half of the cases, a red blood cell transfusion was given. The peak of the platelet count was seen in the first month after the start of iron treatment. In eight cases of children with IDA, the thrombocytopenia appeared after the supplementation of iron was started. Conclusion Clinically stable children with severe IDA and thrombocytopenia, where other causes are very unlikely, warrant an empiric monotherapy with iron to prevent unnecessary investigations and treatments. |
topic |
children erythropoietin iron deficiency anemia thrombocytopenia thrombocytosis |
url |
https://doi.org/10.1002/hsr2.351 |
work_keys_str_mv |
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