Secreted herpes simplex virus-2 glycoprotein G modifies NGF-TrkA signaling to attract free nerve endings to the site of infection.
Herpes simplex virus type 1 (HSV-1) and HSV-2 are highly prevalent viruses that cause a variety of diseases, from cold sores to encephalitis. Both viruses establish latency in peripheral neurons but the molecular mechanisms facilitating the infection of neurons are not fully understood. Using surfac...
Main Authors: | Jorge Rubén Cabrera, Abel Viejo-Borbolla, Nadia Martinez-Martín, Soledad Blanco, Francisco Wandosell, Antonio Alcamí |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC4303327?pdf=render |
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