Factors associated with mortality due to COVID-19 in patients from a public hospital in Tacna, Peru
Objective: To describe the clinical, laboratory and treatment characteristics of COVID-19 patients and to determine the factors associated with mortality during hospital stay. Materials and Methods: Retrospective cohort study of adult COVID-19 inpatients. The clinical, laboratory and treatment data...
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Instituto Nacional de Salud
2021-08-01
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Online Access: | https://rpmesp.ins.gob.pe/rpmesp/article/view/7158 |
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doaj-3958c9fd9fe44874a8a677f2106c56732021-09-03T17:31:09ZspaInstituto Nacional de SaludRevista Peruana de Medicina Experimental y Salud Pública1726-46341726-46422021-08-013822142310.17843/rpmesp.2021.382.71582518Factors associated with mortality due to COVID-19 in patients from a public hospital in Tacna, PeruMiguel Hueda-Zavaleta0Cesar Copaja-Corzo1Fabrizzio Bardales-Silva2Rodrigo Flores-Palacios3Luis Barreto-Rocchetti4Vicente A. Benites-Zapata5Facultad de Ciencias de la Salud, Universidad Privada de Tacna, Tacna, Perú. Hospital III Daniel Alcides Carrión, Tacna, Perú. Médico cirujano, especialista en Enfermedades Infecciosas y TropicalesFacultad de Ciencias de la Salud, Universidad Privada de Tacna, Tacna, Perú. Centro de Investigación de Estudiantes de Medicina, Tacna, Perú. estudiante de Medicina HumanaHospital III Daniel Alcides Carrión, Tacna, Perú. médico cirujano, especialista en Gastroenterología.Hospital III Daniel Alcides Carrión, Tacna, Perú. médico cirujano, especialista en Medicina IntensivaHospital III Daniel Alcides Carrión, Tacna, Perú. químico farmacéutico, especialista en Farmacia ClínicaUniversidad San Ignacio de Loyola, Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Lima, Perú. médico cirujano, maestro en Investigación EpidemiológicaObjective: To describe the clinical, laboratory and treatment characteristics of COVID-19 patients and to determine the factors associated with mortality during hospital stay. Materials and Methods: Retrospective cohort study of adult COVID-19 inpatients. The clinical, laboratory and treatment data were obtained from the medical records of patients from the Hospital Nivel III Daniel Alcides Carrión in Tacna. For the survival analysis we used the Cox proportional hazards model, and we calculated crude and adjusted hazard ratios (HR) with 95% confidence intervals (95% CI). Results: We evaluated 351 patients; 74.1% of them were men. The most common comorbidities were obesity (31.6%), hypertension (27.1%) and diabetes mellitus (24.5%). The median time of hospitalization was 8 days (IQR: 4-15). From the total of patients, 32.9% died during follow-up. The multivariate analysis showed an increased risk of dying associated with the following: age ≥65 years, HR = 3.55 (95% CI: 1.70-7.40); increase in lactate dehydrogenase 720 U/L, HR = 2.08 (95% CI: 1.34-3.22); and oxygen saturation less than 90%, mainly when it was less than 80%, HR = 4.07 (95% CI: 2.10-7.88). In addition, the use of colchicine during treatment showed a protective effect, HR = 0.46 (95% CI: 0.23-0.91). Conclusions: Risk factors for mortality due to COVID-19 included being older than 65 years, having oxygen saturation less than 90%, and elevated lactate dehydrogenase 720 U/L; colchicine treatment could improve the prognosis of patients.https://rpmesp.ins.gob.pe/rpmesp/article/view/7158covid-19sars-cov-2factores de riesgopandemia por nuevo coronavirus 2019neumonía viralinfecciones por coronavirushospitalizaciónmortalidadsupervivenciaperú |
collection |
DOAJ |
language |
Spanish |
format |
Article |
sources |
DOAJ |
author |
Miguel Hueda-Zavaleta Cesar Copaja-Corzo Fabrizzio Bardales-Silva Rodrigo Flores-Palacios Luis Barreto-Rocchetti Vicente A. Benites-Zapata |
spellingShingle |
Miguel Hueda-Zavaleta Cesar Copaja-Corzo Fabrizzio Bardales-Silva Rodrigo Flores-Palacios Luis Barreto-Rocchetti Vicente A. Benites-Zapata Factors associated with mortality due to COVID-19 in patients from a public hospital in Tacna, Peru Revista Peruana de Medicina Experimental y Salud Pública covid-19 sars-cov-2 factores de riesgo pandemia por nuevo coronavirus 2019 neumonía viral infecciones por coronavirus hospitalización mortalidad supervivencia perú |
author_facet |
Miguel Hueda-Zavaleta Cesar Copaja-Corzo Fabrizzio Bardales-Silva Rodrigo Flores-Palacios Luis Barreto-Rocchetti Vicente A. Benites-Zapata |
author_sort |
Miguel Hueda-Zavaleta |
title |
Factors associated with mortality due to COVID-19 in patients from a public hospital in Tacna, Peru |
title_short |
Factors associated with mortality due to COVID-19 in patients from a public hospital in Tacna, Peru |
title_full |
Factors associated with mortality due to COVID-19 in patients from a public hospital in Tacna, Peru |
title_fullStr |
Factors associated with mortality due to COVID-19 in patients from a public hospital in Tacna, Peru |
title_full_unstemmed |
Factors associated with mortality due to COVID-19 in patients from a public hospital in Tacna, Peru |
title_sort |
factors associated with mortality due to covid-19 in patients from a public hospital in tacna, peru |
publisher |
Instituto Nacional de Salud |
series |
Revista Peruana de Medicina Experimental y Salud Pública |
issn |
1726-4634 1726-4642 |
publishDate |
2021-08-01 |
description |
Objective: To describe the clinical, laboratory and treatment characteristics of COVID-19 patients and to determine the factors associated with mortality during hospital stay. Materials and Methods: Retrospective cohort study of adult COVID-19 inpatients. The clinical, laboratory and treatment data were obtained from the medical records of patients from the Hospital Nivel III Daniel Alcides Carrión in Tacna. For the survival analysis we used the Cox proportional hazards model, and we calculated crude and adjusted hazard ratios (HR) with 95% confidence intervals (95% CI). Results: We evaluated 351 patients; 74.1% of them were men. The most common comorbidities were obesity (31.6%), hypertension (27.1%) and diabetes mellitus (24.5%). The median time of hospitalization was 8 days (IQR: 4-15). From the total of patients, 32.9% died during follow-up. The multivariate analysis showed an increased risk of dying associated with the following: age ≥65 years, HR = 3.55 (95% CI: 1.70-7.40); increase in lactate dehydrogenase 720 U/L, HR = 2.08 (95% CI: 1.34-3.22); and oxygen saturation less than 90%, mainly when it was less than 80%, HR = 4.07 (95% CI: 2.10-7.88). In addition, the use of colchicine during treatment showed a protective effect, HR = 0.46 (95% CI: 0.23-0.91). Conclusions: Risk factors for mortality due to COVID-19 included being older than 65 years, having oxygen saturation less than 90%, and elevated lactate dehydrogenase 720 U/L; colchicine treatment could improve the prognosis of patients. |
topic |
covid-19 sars-cov-2 factores de riesgo pandemia por nuevo coronavirus 2019 neumonía viral infecciones por coronavirus hospitalización mortalidad supervivencia perú |
url |
https://rpmesp.ins.gob.pe/rpmesp/article/view/7158 |
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