Mycophenolic Acid Derivatives with Immunosuppressive Activity from the Coral-Derived Fungus Penicillium bialowiezense

Mycophenolic Acid Derivatives with Immunosuppressive Activity from the Coral-Derived Fungus Penicillium bialowiezense

Mycophenolic acid (MPA) is a potent inosine-5′-monophosphate dehydrogenase (IMPDH) inhibitor for immunosuppressive chemotherapy. Most importantly, as the 2-morpholinoethyl ester prodrug of MPA, mycophenolate mofetil (MMF) is a well-known immunosuppressant used to prevent rejection in organ...

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Bibliographic Details
Main Authors: Qing Zhang, Beiye Yang, Fengli Li, Mengting Liu, Shuang Lin, Jianping Wang, Yongbo Xue, Hucheng Zhu, Weiguang Sun, Zhengxi Hu, Yonghui Zhang
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Marine Drugs
Subjects:
coral-derived fungus
Penicillium bialowiezense
Mycophenolic acid derivatives
immunosuppressive activity
molecular docking
Online Access:http://www.mdpi.com/1660-3397/16/7/230

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