Omega-3 fatty acids plus rosuvastatin improves endothelial function in South Asians with dyslipidemia
Catalin Mindrescu1,2,3, Rakesh P Gupta1,3, Eileen V Hermance1, Mary C DeVoe1, Vikas R Soma1, John T Coppola1,2, Cezar S Staniloae1,21Comprehensive Cardiovascular Center, Saint Vincent’s Hospital Manhattan, New York, NY, USA; 2New York Medical College, Valhalla, NY, USA; 3Rakesh P Gupta and...
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doaj-3965dfe5e5bc4c25a212f8776246e93a2020-11-25T01:24:03ZengDove Medical PressVascular Health and Risk Management1178-20482008-12-01Volume 4143914472695Omega-3 fatty acids plus rosuvastatin improves endothelial function in South Asians with dyslipidemiaCatalin MindrescuRakesh P GuptaEileen V HermanceMary C DeVoeVikas R Somaet alCatalin Mindrescu1,2,3, Rakesh P Gupta1,3, Eileen V Hermance1, Mary C DeVoe1, Vikas R Soma1, John T Coppola1,2, Cezar S Staniloae1,21Comprehensive Cardiovascular Center, Saint Vincent’s Hospital Manhattan, New York, NY, USA; 2New York Medical College, Valhalla, NY, USA; 3Rakesh P Gupta and Catalin Mindrescu contributed equally to this article.Background: The present study was undertaken to investigate the effect of statins plus omega-3 polyunsaturated fatty acids (PUFAs) on endothelial function and lipid profile in South Asians with dyslipidemia and endothelial dysfunction, a population at high risk for premature coronary artery disease.Methods: Thirty subjects were randomized to rosuvastatin 10 mg and omega-3-PUFAs 4 g or rosuvastatin 10 mg. After 4 weeks, omega-3-PUFAs were removed from the first group and added to subjects in the second group. All subjects underwent baseline, 4-, and 8-week assessment of endothelial function and lipid profile.Results: Compared to baseline, omega-3-PUFAs plus rosuvastatin improved endothelial-dependent vasodilation (EDV: −1.42% to 11.36%, p = 0.001), and endothelial-independent vasodilation (EIV: 3.4% to 17.37%, p = 0.002). These effects were lost when omega-3-PUFAs were removed (EDV: 11.36% to 0.59%, p = 0.003). In the second group, rosuvastatin alone failed to improve both EDV and EIV compared to baseline. However, adding omega-3-PUFAs to rosuvastatin, significantly improved EDV (−0.66% to 14.73%, p = 0.001) and EIV (11.02% to 24.5%, p = 0.001). Addition of omega-3-PUFAs further improved the lipid profile (triglycerides 139 to 91 mg/dl, p = 0.006, low-density lipoprotein cholesterol 116 to 88 mg/dl, p = 0.014).Conclusions: Combined therapy with omega-3-PUFAs and rosuvastatin improves endothelial function in South Asian subjects with dyslipidemia and endothelial dysfunction.Keywords: omega-3 fatty acids, endothelial function, South Asians, dyslipidemia, rosuvastatinhttps://www.dovepress.com/omega-3-fatty-acids-plus-rosuvastatin-improves-endothelial-function-in-peer-reviewed-article-VHRMOmega-3 Fatty AcidsEndothelial FunctionSouth AsiansDyslipidemiaRosuvastatin. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Catalin Mindrescu Rakesh P Gupta Eileen V Hermance Mary C DeVoe Vikas R Soma et al |
spellingShingle |
Catalin Mindrescu Rakesh P Gupta Eileen V Hermance Mary C DeVoe Vikas R Soma et al Omega-3 fatty acids plus rosuvastatin improves endothelial function in South Asians with dyslipidemia Vascular Health and Risk Management Omega-3 Fatty Acids Endothelial Function South Asians Dyslipidemia Rosuvastatin. |
author_facet |
Catalin Mindrescu Rakesh P Gupta Eileen V Hermance Mary C DeVoe Vikas R Soma et al |
author_sort |
Catalin Mindrescu |
title |
Omega-3 fatty acids plus rosuvastatin improves endothelial function in South Asians with dyslipidemia |
title_short |
Omega-3 fatty acids plus rosuvastatin improves endothelial function in South Asians with dyslipidemia |
title_full |
Omega-3 fatty acids plus rosuvastatin improves endothelial function in South Asians with dyslipidemia |
title_fullStr |
Omega-3 fatty acids plus rosuvastatin improves endothelial function in South Asians with dyslipidemia |
title_full_unstemmed |
Omega-3 fatty acids plus rosuvastatin improves endothelial function in South Asians with dyslipidemia |
title_sort |
omega-3 fatty acids plus rosuvastatin improves endothelial function in south asians with dyslipidemia |
publisher |
Dove Medical Press |
series |
Vascular Health and Risk Management |
issn |
1178-2048 |
publishDate |
2008-12-01 |
description |
Catalin Mindrescu1,2,3, Rakesh P Gupta1,3, Eileen V Hermance1, Mary C DeVoe1, Vikas R Soma1, John T Coppola1,2, Cezar S Staniloae1,21Comprehensive Cardiovascular Center, Saint Vincent’s Hospital Manhattan, New York, NY, USA; 2New York Medical College, Valhalla, NY, USA; 3Rakesh P Gupta and Catalin Mindrescu contributed equally to this article.Background: The present study was undertaken to investigate the effect of statins plus omega-3 polyunsaturated fatty acids (PUFAs) on endothelial function and lipid profile in South Asians with dyslipidemia and endothelial dysfunction, a population at high risk for premature coronary artery disease.Methods: Thirty subjects were randomized to rosuvastatin 10 mg and omega-3-PUFAs 4 g or rosuvastatin 10 mg. After 4 weeks, omega-3-PUFAs were removed from the first group and added to subjects in the second group. All subjects underwent baseline, 4-, and 8-week assessment of endothelial function and lipid profile.Results: Compared to baseline, omega-3-PUFAs plus rosuvastatin improved endothelial-dependent vasodilation (EDV: −1.42% to 11.36%, p = 0.001), and endothelial-independent vasodilation (EIV: 3.4% to 17.37%, p = 0.002). These effects were lost when omega-3-PUFAs were removed (EDV: 11.36% to 0.59%, p = 0.003). In the second group, rosuvastatin alone failed to improve both EDV and EIV compared to baseline. However, adding omega-3-PUFAs to rosuvastatin, significantly improved EDV (−0.66% to 14.73%, p = 0.001) and EIV (11.02% to 24.5%, p = 0.001). Addition of omega-3-PUFAs further improved the lipid profile (triglycerides 139 to 91 mg/dl, p = 0.006, low-density lipoprotein cholesterol 116 to 88 mg/dl, p = 0.014).Conclusions: Combined therapy with omega-3-PUFAs and rosuvastatin improves endothelial function in South Asian subjects with dyslipidemia and endothelial dysfunction.Keywords: omega-3 fatty acids, endothelial function, South Asians, dyslipidemia, rosuvastatin |
topic |
Omega-3 Fatty Acids Endothelial Function South Asians Dyslipidemia Rosuvastatin. |
url |
https://www.dovepress.com/omega-3-fatty-acids-plus-rosuvastatin-improves-endothelial-function-in-peer-reviewed-article-VHRM |
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