ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5

ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5

BackgroundEpithelial-Mesenchymal Transition (EMT) is a major process in the initiation of tumor metastasis, where cancer cells lose sessile epithelial potential and gain mesenchymal phenotype. Large-scale cell identity shifts are often orchestrated on an epigenetic level and the interplay between ep...

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Bibliographic Details
Main Authors: Chaoqin Shen, Tingting Yan, Tianying Tong, Debin Shi, Linlin Ren, Youwei Zhang, Xinyu Zhang, Yingying Cao, Yuqing Yan, Yanru Ma, Xiaoqiang Zhu, Xianglong Tian, Jing-Yuan Fang, Haoyan Chen, Linhua Ji, Jie Hong, Baoqin Xuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CRC
EMT
epigenetic modification
metastasis
ALKBH4
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00293/full

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