Backscattering spectroscopy for assessing skin tumor

• Main Authors: Valery P. Zakharov, Pavel E. Timchenko, Elena V. Timchenko, Larisa A. Zherdeva, Sergey V. Kozlov, Alexander A. Moryatov
• Format: Article
• Language: English
• Published: Samara National Research University 2015-06-01
• Series: Journal of Biomedical Photonics & Engineering
• Subjects: Differential backscattering; discriminant analysis; tumor; noninvasive diagnostics; optical coefficient; melanoma; basal cell carcinoma; nevus
• Online Access: http://jbpe.ssau.ru/index.php/JBPE/article/view/2489

The results of in vitro backscattering spectral studies of 7 nevuses and 27 samples of different skin cancer are presented. The pathology type classification in the two-dimensional phase space formed by the scattering indices at the wavelengths 560 nm, 650 nm, 700 nm, and 760 nm scaled to the healthy skin scattering coefficient value is proposed. It is shown that the sensitivity and specificity of differentiation between the benign and malignant tumors exceeds 86% and 96%, respectively, and their value for selecting melanoma among other malignant tumors falls by 5-8% due to partial overlap of classes in the phase space.