The Biogenesis, Functions, and Roles of circRNAs in Bladder Cancer
Changjiu Li,1,* Xian Fu,2,* Huadong He,1 Chao Chen,2 Yuyong Wang,2 Lugeng He2 1Department of Urology, Affiliated Hangzhou First People’s Hospital, Nanjing Medical University, Hangzhou 310006, Zhejiang Province, People’s Republic of China; 2Department of Urology, Affiliated Hangzh...
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doaj-398b01b00d7a4853b54e3a37c3a7c1292020-11-25T03:21:59ZengDove Medical PressCancer Management and Research1179-13222020-05-01Volume 123673368953903The Biogenesis, Functions, and Roles of circRNAs in Bladder CancerLi CFu XHe HChen CWang YHe LChangjiu Li,1,* Xian Fu,2,* Huadong He,1 Chao Chen,2 Yuyong Wang,2 Lugeng He2 1Department of Urology, Affiliated Hangzhou First People’s Hospital, Nanjing Medical University, Hangzhou 310006, Zhejiang Province, People’s Republic of China; 2Department of Urology, Affiliated Hangzhou First People’s Hospital, Zhejiang University, Hangzhou 310006, Zhejiang Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huadong He Tel +86 18058765837Email harry_lee99@163.comAbstract: Bladder cancer (BCa) is the 10th most prevalent malignancy worldwide and remains a crucial cause of cancer-related morbidity and mortality. Circular RNAs (circRNAs), a large class of endogenous non-coding RNAs, contain unique covalent closed structures and their biogenesis and turnover are regulated by multiple factors. Recently, multiple circRNAs have been found to serve as important factors in several biological processes such as tumorigenesis. An increasing amount of research discovered that circRNAs are dysregulated in multiple cancer tissues compared with matched normal tissues, especially in BCa, indicating that circRNAs can act as biomarkers for the diagnosis and prognosis of BCa. In this review, we focus on the biogenesis, properties, turnover, and functions of circRNAs, summarizing their potential functions and clinical implications in BCa.Keywords: circRNA, circular RNA, biogenesis, microRNA sponge, bladder cancer, biomarkerhttps://www.dovepress.com/the-biogenesis-functions-and-roles-of-circrnas-in-bladder-cancer-peer-reviewed-article-CMARcircrnacircular rnabiogenesismicrorna spongebladder cancerbiomarker; |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li C Fu X He H Chen C Wang Y He L |
spellingShingle |
Li C Fu X He H Chen C Wang Y He L The Biogenesis, Functions, and Roles of circRNAs in Bladder Cancer Cancer Management and Research circrna circular rna biogenesis microrna sponge bladder cancer biomarker; |
author_facet |
Li C Fu X He H Chen C Wang Y He L |
author_sort |
Li C |
title |
The Biogenesis, Functions, and Roles of circRNAs in Bladder Cancer |
title_short |
The Biogenesis, Functions, and Roles of circRNAs in Bladder Cancer |
title_full |
The Biogenesis, Functions, and Roles of circRNAs in Bladder Cancer |
title_fullStr |
The Biogenesis, Functions, and Roles of circRNAs in Bladder Cancer |
title_full_unstemmed |
The Biogenesis, Functions, and Roles of circRNAs in Bladder Cancer |
title_sort |
biogenesis, functions, and roles of circrnas in bladder cancer |
publisher |
Dove Medical Press |
series |
Cancer Management and Research |
issn |
1179-1322 |
publishDate |
2020-05-01 |
description |
Changjiu Li,1,* Xian Fu,2,* Huadong He,1 Chao Chen,2 Yuyong Wang,2 Lugeng He2 1Department of Urology, Affiliated Hangzhou First People’s Hospital, Nanjing Medical University, Hangzhou 310006, Zhejiang Province, People’s Republic of China; 2Department of Urology, Affiliated Hangzhou First People’s Hospital, Zhejiang University, Hangzhou 310006, Zhejiang Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huadong He Tel +86 18058765837Email harry_lee99@163.comAbstract: Bladder cancer (BCa) is the 10th most prevalent malignancy worldwide and remains a crucial cause of cancer-related morbidity and mortality. Circular RNAs (circRNAs), a large class of endogenous non-coding RNAs, contain unique covalent closed structures and their biogenesis and turnover are regulated by multiple factors. Recently, multiple circRNAs have been found to serve as important factors in several biological processes such as tumorigenesis. An increasing amount of research discovered that circRNAs are dysregulated in multiple cancer tissues compared with matched normal tissues, especially in BCa, indicating that circRNAs can act as biomarkers for the diagnosis and prognosis of BCa. In this review, we focus on the biogenesis, properties, turnover, and functions of circRNAs, summarizing their potential functions and clinical implications in BCa.Keywords: circRNA, circular RNA, biogenesis, microRNA sponge, bladder cancer, biomarker |
topic |
circrna circular rna biogenesis microrna sponge bladder cancer biomarker; |
url |
https://www.dovepress.com/the-biogenesis-functions-and-roles-of-circrnas-in-bladder-cancer-peer-reviewed-article-CMAR |
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