Laboratory Markers in the Management of Pediatric Polytrauma: Current Role and Areas of Future Research
Severe trauma is the most common cause of mortality in children and is associated with a high socioeconomic burden. The most frequently injured organs in children are the head and thorax, followed by the extremities and by abdominal injuries. The efficient and early assessment and management of thes...
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2021-03-01
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doaj-398f5affa1494338b653c955cbde55d72021-03-16T05:29:09ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602021-03-01910.3389/fped.2021.622753622753Laboratory Markers in the Management of Pediatric Polytrauma: Current Role and Areas of Future ResearchBirte Weber0Ina Lackner1Christian Karl Braun2Christian Karl Braun3Miriam Kalbitz4Markus Huber-Lang5Jochen Pressmar6Department of Traumatology, Hand-, Plastic- and Reconstructive Surgery, Center of Surgery, University of Ulm, Ulm, GermanyDepartment of Traumatology, Hand-, Plastic- and Reconstructive Surgery, Center of Surgery, University of Ulm, Ulm, GermanyInstitute of Clinical and Experimental Trauma-Immunology, University Hospital of Ulm, Ulm, GermanyDepartment of Pediatrics, University Medical Center Ulm, Ulm, GermanyDepartment of Traumatology, Hand-, Plastic- and Reconstructive Surgery, Center of Surgery, University of Ulm, Ulm, GermanyInstitute of Clinical and Experimental Trauma-Immunology, University Hospital of Ulm, Ulm, GermanyDepartment of Traumatology, Hand-, Plastic- and Reconstructive Surgery, Center of Surgery, University of Ulm, Ulm, GermanySevere trauma is the most common cause of mortality in children and is associated with a high socioeconomic burden. The most frequently injured organs in children are the head and thorax, followed by the extremities and by abdominal injuries. The efficient and early assessment and management of these injuries is essential to improve patients' outcome. Physical examination as well as imaging techniques like ultrasound, X-ray and computer tomography are crucial for a valid early diagnosis. Furthermore, laboratory analyses constitute additional helpful tools for the detection and monitoring of pediatric injuries. Specific inflammatory markers correlate with post-traumatic complications, including the development of multiple organ failure. Other laboratory parameters, including lactate concentration, coagulation parameters and markers of organ injury, represent further clinical tools to identify trauma-induced disorders. In this review, we outline and evaluate specific biomarkers for inflammation, acid-base balance, blood coagulation and organ damage following pediatric polytrauma. The early use of relevant laboratory markers may assist decision making on imaging tools, thus contributing to minimize radiation-induced long-term consequences, while improving the outcome of children with multiple trauma.https://www.frontiersin.org/articles/10.3389/fped.2021.622753/fullorgan injurybiomarkeremergency room managementlaboratory parameterscoagulationinflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Birte Weber Ina Lackner Christian Karl Braun Christian Karl Braun Miriam Kalbitz Markus Huber-Lang Jochen Pressmar |
spellingShingle |
Birte Weber Ina Lackner Christian Karl Braun Christian Karl Braun Miriam Kalbitz Markus Huber-Lang Jochen Pressmar Laboratory Markers in the Management of Pediatric Polytrauma: Current Role and Areas of Future Research Frontiers in Pediatrics organ injury biomarker emergency room management laboratory parameters coagulation inflammation |
author_facet |
Birte Weber Ina Lackner Christian Karl Braun Christian Karl Braun Miriam Kalbitz Markus Huber-Lang Jochen Pressmar |
author_sort |
Birte Weber |
title |
Laboratory Markers in the Management of Pediatric Polytrauma: Current Role and Areas of Future Research |
title_short |
Laboratory Markers in the Management of Pediatric Polytrauma: Current Role and Areas of Future Research |
title_full |
Laboratory Markers in the Management of Pediatric Polytrauma: Current Role and Areas of Future Research |
title_fullStr |
Laboratory Markers in the Management of Pediatric Polytrauma: Current Role and Areas of Future Research |
title_full_unstemmed |
Laboratory Markers in the Management of Pediatric Polytrauma: Current Role and Areas of Future Research |
title_sort |
laboratory markers in the management of pediatric polytrauma: current role and areas of future research |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pediatrics |
issn |
2296-2360 |
publishDate |
2021-03-01 |
description |
Severe trauma is the most common cause of mortality in children and is associated with a high socioeconomic burden. The most frequently injured organs in children are the head and thorax, followed by the extremities and by abdominal injuries. The efficient and early assessment and management of these injuries is essential to improve patients' outcome. Physical examination as well as imaging techniques like ultrasound, X-ray and computer tomography are crucial for a valid early diagnosis. Furthermore, laboratory analyses constitute additional helpful tools for the detection and monitoring of pediatric injuries. Specific inflammatory markers correlate with post-traumatic complications, including the development of multiple organ failure. Other laboratory parameters, including lactate concentration, coagulation parameters and markers of organ injury, represent further clinical tools to identify trauma-induced disorders. In this review, we outline and evaluate specific biomarkers for inflammation, acid-base balance, blood coagulation and organ damage following pediatric polytrauma. The early use of relevant laboratory markers may assist decision making on imaging tools, thus contributing to minimize radiation-induced long-term consequences, while improving the outcome of children with multiple trauma. |
topic |
organ injury biomarker emergency room management laboratory parameters coagulation inflammation |
url |
https://www.frontiersin.org/articles/10.3389/fped.2021.622753/full |
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