The effect of Mexidol on magnesium-calcium balance and endothelial dysfunction in operational stress
<p>The aim of the study: to study the effect of mexidol content of ionized calcium and magnesium in erythrocytes and the number of circulating endothelial cells in patients undergoing surgery in the maxillofacial area. Material and methods. The intracellular concentration of calcium and magnes...
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Saratov State Medical University
2014-03-01
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doaj-39908e4ce88145879e2e1c766be35eae2021-07-02T08:54:51ZrusSaratov State Medical UniversityСаратовский научно-медицинский журнал2076-25182014-03-011011671703642The effect of Mexidol on magnesium-calcium balance and endothelial dysfunction in operational stressBaturin V.A.0Fisher V.V.1Sergeev S.A.2Yatsuk I.V.3Stavropol State Medical UniversityStavropol State Medical UniversityStavropol State Medical UniversityStavropol State Medical University<p>The aim of the study: to study the effect of mexidol content of ionized calcium and magnesium in erythrocytes and the number of circulating endothelial cells in patients undergoing surgery in the maxillofacial area. Material and methods. The intracellular concentration of calcium and magnesium was measured before the operation, in one, three and five days after the surgery with the help of cytochemical method. Mexidol (100mg) was administered intravenously as a single addition to the standard premedication. Results. After surgery, the intracellular calcium and magnesium content increased. After 24 hours, the magnesium level began to decline, and the calcium content in erythrocytes continued to grow. On day 5, the magnesium concentration in erythrocytes decreased below the initial level, and calcium levels remained significantly elevated. Number of endothelial cells in the blood increased immediately after surgery and magnesium-calcium balance and limits endothelial dysfunction. Mexidol continued growing, reaching a peak on day 5 after surgery. When using mexidol decreased levels of calcium and magnesium levels help prevent falls on the 5th day after surgery, decreased the number of circulating endothelial cells. Conclusion. Mexidol prevents postoperative magnesium violation.</p>http://www.ssmj.ru/system/files/2014_01-01_167-170.pdfendothelium cellsintracellular calciumintracellular magnesiummexidoloperational stress |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
Baturin V.A. Fisher V.V. Sergeev S.A. Yatsuk I.V. |
spellingShingle |
Baturin V.A. Fisher V.V. Sergeev S.A. Yatsuk I.V. The effect of Mexidol on magnesium-calcium balance and endothelial dysfunction in operational stress Саратовский научно-медицинский журнал endothelium cells intracellular calcium intracellular magnesium mexidol operational stress |
author_facet |
Baturin V.A. Fisher V.V. Sergeev S.A. Yatsuk I.V. |
author_sort |
Baturin V.A. |
title |
The effect of Mexidol on magnesium-calcium balance and endothelial dysfunction in operational stress |
title_short |
The effect of Mexidol on magnesium-calcium balance and endothelial dysfunction in operational stress |
title_full |
The effect of Mexidol on magnesium-calcium balance and endothelial dysfunction in operational stress |
title_fullStr |
The effect of Mexidol on magnesium-calcium balance and endothelial dysfunction in operational stress |
title_full_unstemmed |
The effect of Mexidol on magnesium-calcium balance and endothelial dysfunction in operational stress |
title_sort |
effect of mexidol on magnesium-calcium balance and endothelial dysfunction in operational stress |
publisher |
Saratov State Medical University |
series |
Саратовский научно-медицинский журнал |
issn |
2076-2518 |
publishDate |
2014-03-01 |
description |
<p>The aim of the study: to study the effect of mexidol content of ionized calcium and magnesium in erythrocytes and the number of circulating endothelial cells in patients undergoing surgery in the maxillofacial area. Material and methods. The intracellular concentration of calcium and magnesium was measured before the operation, in one, three and five days after the surgery with the help of cytochemical method. Mexidol (100mg) was administered intravenously as a single addition to the standard premedication. Results. After surgery, the intracellular calcium and magnesium content increased. After 24 hours, the magnesium level began to decline, and the calcium content in erythrocytes continued to grow. On day 5, the magnesium concentration in erythrocytes decreased below the initial level, and calcium levels remained significantly elevated. Number of endothelial cells in the blood increased immediately after surgery and magnesium-calcium balance and limits endothelial dysfunction. Mexidol continued growing, reaching a peak on day 5 after surgery. When using mexidol decreased levels of calcium and magnesium levels help prevent falls on the 5th day after surgery, decreased the number of circulating endothelial cells. Conclusion. Mexidol prevents postoperative magnesium violation.</p> |
topic |
endothelium cells intracellular calcium intracellular magnesium mexidol operational stress |
url |
http://www.ssmj.ru/system/files/2014_01-01_167-170.pdf |
work_keys_str_mv |
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