A pilot study to profile salivary angiogenic factors to detect head and neck cancers

Abstract Background Early diagnosis of head and neck squamous cell carcinoma (HNSCCs) is an appealing way to increase survival rates in these patients as well as to improve quality of life post-surgery. Angiogenesis is a hallmark of tumor initiation and progression. We have investigated a panel of a...

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Main Authors:	L. van der Merwe, Y. Wan, H. J. Cheong, C. Perry, C. Punyadeera
Format:	Article
Language:	English
Published:	BMC 2018-07-01
Series:	BMC Cancer
Subjects:	Angiogenesis Saliva Human papillomavirus Head and neck squamous cell carcinoma
Online Access:	http://link.springer.com/article/10.1186/s12885-018-4656-3

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spelling	doaj-3995f7229b51467fb6a8e2cb0be24fe92020-11-25T00:43:12ZengBMCBMC Cancer1471-24072018-07-011811810.1186/s12885-018-4656-3A pilot study to profile salivary angiogenic factors to detect head and neck cancersL. van der Merwe0Y. Wan1H. J. Cheong2C. Perry3C. Punyadeera4The School of Biomedical Sciences, Institute of Health and Biomedical Innovations, Queensland University of TechnologyThe School of Biomedical Sciences, Institute of Health and Biomedical Innovations, Queensland University of TechnologyThe School of Biomedical Sciences, Institute of Health and Biomedical Innovations, Queensland University of TechnologyDepartment of Otolaryngology, Princess Alexandra HospitalThe School of Biomedical Sciences, Institute of Health and Biomedical Innovations, Queensland University of TechnologyAbstract Background Early diagnosis of head and neck squamous cell carcinoma (HNSCCs) is an appealing way to increase survival rates in these patients as well as to improve quality of life post-surgery. Angiogenesis is a hallmark of tumor initiation and progression. We have investigated a panel of angiogenic factors in saliva samples collected from HNSCC patients and controls using the Bio-Plex ProTM assays. Methods We have identified a panel of five angiogenic proteins (sEGFR, HGF, sHER2, sIL-6Ra and PECAM-1) to be elevated in the saliva samples collected from HNSCC patients (n = 58) compared to a control cohort (n = 8 smokers and n = 30 non-smokers). Results High positive correlations were observed between the following sets of salivary proteins; sEGFR:sHER2, sEGFR:HGF, sEGFR:sIL-6Rα, sHER2:HGF and sHER2:sIL6Ra. A moderate positive correlation was seen between FGF-basic and sEGFR. Conclusion We have shown that angiogenic factor levels in saliva can be used as a potential diagnostic biomarker panel in HNSCC.http://link.springer.com/article/10.1186/s12885-018-4656-3AngiogenesisSalivaHuman papillomavirusHead and neck squamous cell carcinoma
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	L. van der Merwe Y. Wan H. J. Cheong C. Perry C. Punyadeera
spellingShingle	L. van der Merwe Y. Wan H. J. Cheong C. Perry C. Punyadeera A pilot study to profile salivary angiogenic factors to detect head and neck cancers BMC Cancer Angiogenesis Saliva Human papillomavirus Head and neck squamous cell carcinoma
author_facet	L. van der Merwe Y. Wan H. J. Cheong C. Perry C. Punyadeera
author_sort	L. van der Merwe
title	A pilot study to profile salivary angiogenic factors to detect head and neck cancers
title_short	A pilot study to profile salivary angiogenic factors to detect head and neck cancers
title_full	A pilot study to profile salivary angiogenic factors to detect head and neck cancers
title_fullStr	A pilot study to profile salivary angiogenic factors to detect head and neck cancers
title_full_unstemmed	A pilot study to profile salivary angiogenic factors to detect head and neck cancers
title_sort	pilot study to profile salivary angiogenic factors to detect head and neck cancers
publisher	BMC
series	BMC Cancer
issn	1471-2407
publishDate	2018-07-01
description	Abstract Background Early diagnosis of head and neck squamous cell carcinoma (HNSCCs) is an appealing way to increase survival rates in these patients as well as to improve quality of life post-surgery. Angiogenesis is a hallmark of tumor initiation and progression. We have investigated a panel of angiogenic factors in saliva samples collected from HNSCC patients and controls using the Bio-Plex ProTM assays. Methods We have identified a panel of five angiogenic proteins (sEGFR, HGF, sHER2, sIL-6Ra and PECAM-1) to be elevated in the saliva samples collected from HNSCC patients (n = 58) compared to a control cohort (n = 8 smokers and n = 30 non-smokers). Results High positive correlations were observed between the following sets of salivary proteins; sEGFR:sHER2, sEGFR:HGF, sEGFR:sIL-6Rα, sHER2:HGF and sHER2:sIL6Ra. A moderate positive correlation was seen between FGF-basic and sEGFR. Conclusion We have shown that angiogenic factor levels in saliva can be used as a potential diagnostic biomarker panel in HNSCC.
topic	Angiogenesis Saliva Human papillomavirus Head and neck squamous cell carcinoma
url	http://link.springer.com/article/10.1186/s12885-018-4656-3
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A pilot study to profile salivary angiogenic factors to detect head and neck cancers

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