The usefulness of trabecular bone score in patients with ankylosing spondylitis
Backgrounds/Aims This study was performed to reveal the usefulness of the trabecular bone score (TBS) in assessing bone strength in patients with ankylosing spondylitis (AS) in comparison with dual-energy X-ray absorptiometry (DXA) methods. Methods A total of 215 AS patients (75.8% male) were enroll...
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doaj-399a3facaa5a43e6aff17677a9aa7f5c2021-09-13T01:34:22ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482021-09-013651211122010.3904/kjim.2020.065170406The usefulness of trabecular bone score in patients with ankylosing spondylitisSeoung Wan Nam0Yoon-Kyoung Sung1Dam Kim2Soo-Kyung Cho3Yoonah Song4Yun Young Choi5Yongjin Sim6Tae-Hwan Kim7 Department of Rheumatology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea Division of Rheumatology, Department of Internal Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea Department of Radiology, Kok Hospital, Seongnam, Korea Department of Nuclear Medicine, Hanyang University Medical Center, Seoul, Korea Department of Information Statistics, Yonsei University Mirae Campus, Wonju, Korea Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, KoreaBackgrounds/Aims This study was performed to reveal the usefulness of the trabecular bone score (TBS) in assessing bone strength in patients with ankylosing spondylitis (AS) in comparison with dual-energy X-ray absorptiometry (DXA) methods. Methods A total of 215 AS patients (75.8% male) were enrolled from a single university hospital in Korea. Demographic and clinical information were assessed. Patients completed X-rays of the cervical and lumbar spine (L-spine), and spinal ankyloses were quantified using the modified Stoke AS Spine Score (mSASSS). Hip, anteroposterior and lateral L-spine bone mineral density (BMD) and TBS were assessed by DXA methods. Clinical characteristics and bone strength measurement results were compared between male and female AS patients. The accuracy of each bone strength evaluation method in predicting Fracture Risk Assessment Tool (FRAX) scores indicating moderate or higher fracture risk was compared by receiver operating characteristic curves in patients aged ≥ 40 years. Correlations between each bone strength measurement method and mSASSS were examined. Results Male patients showed higher mSASSS and less prevalent peripheral joint involvement compared to female patients (p < 0.05). TBS, hip BMD, and L-spine lateral BMD showed comparably high areas under the curve (AUCs) for predicting FRAX-major osteoporotic fractures (MOF) ≥ 10% (AUC ranged 0.72 to 0.76). TBS negatively correlated with mSASSS in both male and female patients (p < 0.01). Conclusions TBS could predict the risk of MOF and is not influenced by spinal osteoproliferation in AS patients, even in those with advanced spinal changes.http://www.kjim.org/upload/pdf/kjim-2020-065.pdfboneosteoporosisankylosing spondylitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Seoung Wan Nam Yoon-Kyoung Sung Dam Kim Soo-Kyung Cho Yoonah Song Yun Young Choi Yongjin Sim Tae-Hwan Kim |
spellingShingle |
Seoung Wan Nam Yoon-Kyoung Sung Dam Kim Soo-Kyung Cho Yoonah Song Yun Young Choi Yongjin Sim Tae-Hwan Kim The usefulness of trabecular bone score in patients with ankylosing spondylitis The Korean Journal of Internal Medicine bone osteoporosis ankylosing spondylitis |
author_facet |
Seoung Wan Nam Yoon-Kyoung Sung Dam Kim Soo-Kyung Cho Yoonah Song Yun Young Choi Yongjin Sim Tae-Hwan Kim |
author_sort |
Seoung Wan Nam |
title |
The usefulness of trabecular bone score in patients with ankylosing spondylitis |
title_short |
The usefulness of trabecular bone score in patients with ankylosing spondylitis |
title_full |
The usefulness of trabecular bone score in patients with ankylosing spondylitis |
title_fullStr |
The usefulness of trabecular bone score in patients with ankylosing spondylitis |
title_full_unstemmed |
The usefulness of trabecular bone score in patients with ankylosing spondylitis |
title_sort |
usefulness of trabecular bone score in patients with ankylosing spondylitis |
publisher |
The Korean Association of Internal Medicine |
series |
The Korean Journal of Internal Medicine |
issn |
1226-3303 2005-6648 |
publishDate |
2021-09-01 |
description |
Backgrounds/Aims This study was performed to reveal the usefulness of the trabecular bone score (TBS) in assessing bone strength in patients with ankylosing spondylitis (AS) in comparison with dual-energy X-ray absorptiometry (DXA) methods. Methods A total of 215 AS patients (75.8% male) were enrolled from a single university hospital in Korea. Demographic and clinical information were assessed. Patients completed X-rays of the cervical and lumbar spine (L-spine), and spinal ankyloses were quantified using the modified Stoke AS Spine Score (mSASSS). Hip, anteroposterior and lateral L-spine bone mineral density (BMD) and TBS were assessed by DXA methods. Clinical characteristics and bone strength measurement results were compared between male and female AS patients. The accuracy of each bone strength evaluation method in predicting Fracture Risk Assessment Tool (FRAX) scores indicating moderate or higher fracture risk was compared by receiver operating characteristic curves in patients aged ≥ 40 years. Correlations between each bone strength measurement method and mSASSS were examined. Results Male patients showed higher mSASSS and less prevalent peripheral joint involvement compared to female patients (p < 0.05). TBS, hip BMD, and L-spine lateral BMD showed comparably high areas under the curve (AUCs) for predicting FRAX-major osteoporotic fractures (MOF) ≥ 10% (AUC ranged 0.72 to 0.76). TBS negatively correlated with mSASSS in both male and female patients (p < 0.01). Conclusions TBS could predict the risk of MOF and is not influenced by spinal osteoproliferation in AS patients, even in those with advanced spinal changes. |
topic |
bone osteoporosis ankylosing spondylitis |
url |
http://www.kjim.org/upload/pdf/kjim-2020-065.pdf |
work_keys_str_mv |
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