Role of the kidney in the metabolism of apolipoprotein A-IV: influence of the type of proteinuria
Increased plasma concentrations of apolipoprotein A-IV (apoA-IV) in chronic renal disease suggest a metabolic role of the kidney for this antiatherogenic protein. Therefore, we investigated patients with various forms of proteinuria and found increased serum concentrations of apoA-IV in 124 nephroti...
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doaj-39abff5317544836867a6099d9b810712021-04-27T04:47:51ZengElsevierJournal of Lipid Research0022-22752006-09-0147920712079Role of the kidney in the metabolism of apolipoprotein A-IV: influence of the type of proteinuriaArno Lingenhel0Karl Lhotta1Ulrich Neyer2Iris M. Heid3Barbara Rantner4Martina F. Kronenberg5Paul König6Arnold von Eckardstein7Maria Schober8Hans Dieplinger9Florian Kronenberg10Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, AustriaDepartment of Clinical Nephrology, Innsbruck Medical University, Innsbruck, AustriaDepartment of Nephrology and Dialysis, Academic Teaching Hospital, Feldkirch, AustriaInstitute of Epidemiology, GSF-National Research Center for Environment and Health, Neuherberg, Germany; Institute of Biostatistics and Epidemiology, Ludwig-Maximilians-Universität München, Munich, GermanyDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, AustriaDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, AustriaDepartment of Clinical Nephrology, Innsbruck Medical University, Innsbruck, AustriaInstitute of Clinical Chemistry, University and University Hospital of Zürich, Zürich, SwitzerlandCentral Laboratory of University Clinics, Innsbruck Medical University, Innsbruck, AustriaDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, AustriaDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, AustriaIncreased plasma concentrations of apolipoprotein A-IV (apoA-IV) in chronic renal disease suggest a metabolic role of the kidney for this antiatherogenic protein. Therefore, we investigated patients with various forms of proteinuria and found increased serum concentrations of apoA-IV in 124 nephrotic patients compared with 274 controls (mean 21.9 ± 9.6 vs. 14.4 ± 4.0 mg/dl; P < 0.001). Decreasing creatinine clearance showed a strong association with increasing apoA-IV levels. However, serum albumin levels significantly modulated apoA-IV levels in patients with low creatinine clearance, resulting in lower levels of apoA-IV in patients with low compared with high albumin levels (21.4 ± 8.6 vs. 29.2 ± 8.4 mg/dl; P = 0.0007). Furthermore, we investigated urinary apoA-IV levels in an additional 66 patients with a wide variety of proteinuria and 30 controls. Especially patients with a tubular type of proteinuria had significantly higher amounts of apoA-IV in urine than those with a pure glomerular type of proteinuria and controls (median 45, 14, and 0.6 ng/mg creatinine, respectively). We confirmed these results in affected members of a family with Dent's disease, who are characterized by an inherited protein reabsorption defect of the proximal tubular system. In summary, our data demonstrate that the increase of apoA-IV caused by renal impairment is significantly modulated by low levels of serum albumin as a measure for the severity of the nephrotic syndrome. From this investigation of apoA-IV in urine as well as earlier immunohistochemical studies, we conclude that apoA-IV is filtered through the normal glomerulus and is subsequently reabsorbed mainly by proximal tubular cells.http://www.sciencedirect.com/science/article/pii/S0022227520434753nephrotic syndrometubular proteinuriaatherosclerosisDent's disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Arno Lingenhel Karl Lhotta Ulrich Neyer Iris M. Heid Barbara Rantner Martina F. Kronenberg Paul König Arnold von Eckardstein Maria Schober Hans Dieplinger Florian Kronenberg |
spellingShingle |
Arno Lingenhel Karl Lhotta Ulrich Neyer Iris M. Heid Barbara Rantner Martina F. Kronenberg Paul König Arnold von Eckardstein Maria Schober Hans Dieplinger Florian Kronenberg Role of the kidney in the metabolism of apolipoprotein A-IV: influence of the type of proteinuria Journal of Lipid Research nephrotic syndrome tubular proteinuria atherosclerosis Dent's disease |
author_facet |
Arno Lingenhel Karl Lhotta Ulrich Neyer Iris M. Heid Barbara Rantner Martina F. Kronenberg Paul König Arnold von Eckardstein Maria Schober Hans Dieplinger Florian Kronenberg |
author_sort |
Arno Lingenhel |
title |
Role of the kidney in the metabolism of apolipoprotein A-IV: influence of the type of proteinuria |
title_short |
Role of the kidney in the metabolism of apolipoprotein A-IV: influence of the type of proteinuria |
title_full |
Role of the kidney in the metabolism of apolipoprotein A-IV: influence of the type of proteinuria |
title_fullStr |
Role of the kidney in the metabolism of apolipoprotein A-IV: influence of the type of proteinuria |
title_full_unstemmed |
Role of the kidney in the metabolism of apolipoprotein A-IV: influence of the type of proteinuria |
title_sort |
role of the kidney in the metabolism of apolipoprotein a-iv: influence of the type of proteinuria |
publisher |
Elsevier |
series |
Journal of Lipid Research |
issn |
0022-2275 |
publishDate |
2006-09-01 |
description |
Increased plasma concentrations of apolipoprotein A-IV (apoA-IV) in chronic renal disease suggest a metabolic role of the kidney for this antiatherogenic protein. Therefore, we investigated patients with various forms of proteinuria and found increased serum concentrations of apoA-IV in 124 nephrotic patients compared with 274 controls (mean 21.9 ± 9.6 vs. 14.4 ± 4.0 mg/dl; P < 0.001). Decreasing creatinine clearance showed a strong association with increasing apoA-IV levels. However, serum albumin levels significantly modulated apoA-IV levels in patients with low creatinine clearance, resulting in lower levels of apoA-IV in patients with low compared with high albumin levels (21.4 ± 8.6 vs. 29.2 ± 8.4 mg/dl; P = 0.0007). Furthermore, we investigated urinary apoA-IV levels in an additional 66 patients with a wide variety of proteinuria and 30 controls. Especially patients with a tubular type of proteinuria had significantly higher amounts of apoA-IV in urine than those with a pure glomerular type of proteinuria and controls (median 45, 14, and 0.6 ng/mg creatinine, respectively). We confirmed these results in affected members of a family with Dent's disease, who are characterized by an inherited protein reabsorption defect of the proximal tubular system. In summary, our data demonstrate that the increase of apoA-IV caused by renal impairment is significantly modulated by low levels of serum albumin as a measure for the severity of the nephrotic syndrome. From this investigation of apoA-IV in urine as well as earlier immunohistochemical studies, we conclude that apoA-IV is filtered through the normal glomerulus and is subsequently reabsorbed mainly by proximal tubular cells. |
topic |
nephrotic syndrome tubular proteinuria atherosclerosis Dent's disease |
url |
http://www.sciencedirect.com/science/article/pii/S0022227520434753 |
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