Classical and alternative activation and metalloproteinase expression occurs in foam cell macrophages in male and female ApoE null mice in the absence of T- and B-lymphocytes
Background: Rupture of advanced atherosclerotic plaques accounts for most life-threatening myocardial infarctions. Classical (M1) and alternative (M2) macrophage activation could promote atherosclerotic plaque progression and rupture by increasing production of proteases, including matrix metallopro...
Main Authors: | Elaine Mo Hayes, Aikaterini eTsaousi, Karina eDi Gregoli, S Rhiannon Jenkinson, Andrew R Bond, Jason L Johnson, Laura eBevan, Anita C Thomas, Andrew C Newby |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2014-10-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00537/full |
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