Classical and alternative activation and metalloproteinase expression occurs in foam cell macrophages in male and female ApoE null mice in the absence of T- and B-lymphocytes

Classical and alternative activation and metalloproteinase expression occurs in foam cell macrophages in male and female ApoE null mice in the absence of T- and B-lymphocytes

Background: Rupture of advanced atherosclerotic plaques accounts for most life-threatening myocardial infarctions. Classical (M1) and alternative (M2) macrophage activation could promote atherosclerotic plaque progression and rupture by increasing production of proteases, including matrix metallopro...

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Bibliographic Details
Main Authors: Elaine Mo Hayes, Aikaterini eTsaousi, Karina eDi Gregoli, S Rhiannon Jenkinson, Andrew R Bond, Jason L Johnson, Laura eBevan, Anita C Thomas, Andrew C Newby
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Immunology
Subjects:
Atherosclerosis
Cytokines
Lymphocytes
Macrophages
Plaque rupture
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00537/full

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