The Role of Histone Acetylation and the Microbiome in Phytochemical Efficacy for Cardiovascular Diseases
Cardiovascular diseases (CVD) are the main cause of death worldwide and create a substantial financial burden. Emerging studies have begun to focus on epigenetic targets and re-establishing healthy gut microbes as therapeutic options for the treatment and prevention of CVD. Phytochemicals, commonly...
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doaj-39ad30e0e33a429bbb19fde09e841fdf2020-11-25T03:20:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-06-01214006400610.3390/ijms21114006The Role of Histone Acetylation and the Microbiome in Phytochemical Efficacy for Cardiovascular DiseasesLevi W. Evans0Maheshi Athukorala1Kristina Martinez-Guryn2Bradley S. Ferguson3Department of Nutrition, University of Nevada Reno, Reno, NV 89557, USADepartment of Nutrition, University of Nevada Reno, Reno, NV 89557, USADepartment of Biomedical Sciences, Midwestern University, Downers Grove, IL 60515, USADepartment of Nutrition, University of Nevada Reno, Reno, NV 89557, USACardiovascular diseases (CVD) are the main cause of death worldwide and create a substantial financial burden. Emerging studies have begun to focus on epigenetic targets and re-establishing healthy gut microbes as therapeutic options for the treatment and prevention of CVD. Phytochemicals, commonly found in fruits and vegetables, have been shown to exert a protective effect against CVD, though their mechanisms of action remain incompletely understood. Of interest, phytochemicals such as curcumin, resveratrol and epigallocatechin gallate (EGCG) have been shown to regulate both histone acetylation and microbiome re-composition. The purpose of this review is to highlight the microbiome–epigenome axis as a therapeutic target for food bioactives in the prevention and/or treatment of CVD. Specifically, we will discuss studies that highlight how the three phytochemicals above alter histone acetylation leading to global changes in gene expression and CVD protection. Then, we will expand upon these phytochemicals to discuss the impact of phytochemical–microbiome–histone acetylation interaction in CVD.https://www.mdpi.com/1422-0067/21/11/4006Phytochemicalshistone acetylationhistone deacetylase (HDAC), microbiomemicrobiotaheart |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Levi W. Evans Maheshi Athukorala Kristina Martinez-Guryn Bradley S. Ferguson |
spellingShingle |
Levi W. Evans Maheshi Athukorala Kristina Martinez-Guryn Bradley S. Ferguson The Role of Histone Acetylation and the Microbiome in Phytochemical Efficacy for Cardiovascular Diseases International Journal of Molecular Sciences Phytochemicals histone acetylation histone deacetylase (HDAC), microbiome microbiota heart |
author_facet |
Levi W. Evans Maheshi Athukorala Kristina Martinez-Guryn Bradley S. Ferguson |
author_sort |
Levi W. Evans |
title |
The Role of Histone Acetylation and the Microbiome in Phytochemical Efficacy for Cardiovascular Diseases |
title_short |
The Role of Histone Acetylation and the Microbiome in Phytochemical Efficacy for Cardiovascular Diseases |
title_full |
The Role of Histone Acetylation and the Microbiome in Phytochemical Efficacy for Cardiovascular Diseases |
title_fullStr |
The Role of Histone Acetylation and the Microbiome in Phytochemical Efficacy for Cardiovascular Diseases |
title_full_unstemmed |
The Role of Histone Acetylation and the Microbiome in Phytochemical Efficacy for Cardiovascular Diseases |
title_sort |
role of histone acetylation and the microbiome in phytochemical efficacy for cardiovascular diseases |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-06-01 |
description |
Cardiovascular diseases (CVD) are the main cause of death worldwide and create a substantial financial burden. Emerging studies have begun to focus on epigenetic targets and re-establishing healthy gut microbes as therapeutic options for the treatment and prevention of CVD. Phytochemicals, commonly found in fruits and vegetables, have been shown to exert a protective effect against CVD, though their mechanisms of action remain incompletely understood. Of interest, phytochemicals such as curcumin, resveratrol and epigallocatechin gallate (EGCG) have been shown to regulate both histone acetylation and microbiome re-composition. The purpose of this review is to highlight the microbiome–epigenome axis as a therapeutic target for food bioactives in the prevention and/or treatment of CVD. Specifically, we will discuss studies that highlight how the three phytochemicals above alter histone acetylation leading to global changes in gene expression and CVD protection. Then, we will expand upon these phytochemicals to discuss the impact of phytochemical–microbiome–histone acetylation interaction in CVD. |
topic |
Phytochemicals histone acetylation histone deacetylase (HDAC), microbiome microbiota heart |
url |
https://www.mdpi.com/1422-0067/21/11/4006 |
work_keys_str_mv |
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