Cancer-selective induction of apotosis by leczyme
Sialic acid-binding lectin (SBL) is a multifunctional protein that is isolated from oocytes of Rana catesbeiana. It has both lectin and ribonuclease (enzyme) properties, and therefore is called leczyme. We examined the antitumor effects of SBL and discovered that SBL has potential as a new type of a...
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doaj-39bc55a4aa84450288ed55d89f7225fb2020-11-24T21:33:06ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2014-06-01410.3389/fonc.2014.0013992396Cancer-selective induction of apotosis by leczymeTakeo eTatsuta0Sigeki eSugawara1Kohta eTakahashi2Yukiko eOgawa3Masahiro eHosono4Kazuo eNitta5Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical UniversityInstitute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical UniversityInstitute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical UniversityNagasaki International UniversityInstitute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical UniversityInstitute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical UniversitySialic acid-binding lectin (SBL) is a multifunctional protein that is isolated from oocytes of Rana catesbeiana. It has both lectin and ribonuclease (enzyme) properties, and therefore is called leczyme. We examined the antitumor effects of SBL and discovered that SBL has potential as a new type of anticancer drug. SBL causes a cancer-selective induction of apoptosis by multiple signaling pathways whereby RNA is its target. It is suggested that the mitochondrial pathway and endoplasmic reticulum stress-mediated pathway participate in SBL-induced signaling. The synergistic antitumor effects with other molecules, such as tumor necrosis factor-related apoptosis ligand (TRAIL) and interferon γ (IFN-γ), have been reported. In this study, we summarize the effects of SBL and focus on its cancer-selective apoptotic properties. In addition, we present a possible explanation its cancer specificity.http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00139/fullApoptosisleczymecancer selectivitysialic acid-binding lectincytotoxic ribonuclease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Takeo eTatsuta Sigeki eSugawara Kohta eTakahashi Yukiko eOgawa Masahiro eHosono Kazuo eNitta |
spellingShingle |
Takeo eTatsuta Sigeki eSugawara Kohta eTakahashi Yukiko eOgawa Masahiro eHosono Kazuo eNitta Cancer-selective induction of apotosis by leczyme Frontiers in Oncology Apoptosis leczyme cancer selectivity sialic acid-binding lectin cytotoxic ribonuclease |
author_facet |
Takeo eTatsuta Sigeki eSugawara Kohta eTakahashi Yukiko eOgawa Masahiro eHosono Kazuo eNitta |
author_sort |
Takeo eTatsuta |
title |
Cancer-selective induction of apotosis by leczyme |
title_short |
Cancer-selective induction of apotosis by leczyme |
title_full |
Cancer-selective induction of apotosis by leczyme |
title_fullStr |
Cancer-selective induction of apotosis by leczyme |
title_full_unstemmed |
Cancer-selective induction of apotosis by leczyme |
title_sort |
cancer-selective induction of apotosis by leczyme |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2014-06-01 |
description |
Sialic acid-binding lectin (SBL) is a multifunctional protein that is isolated from oocytes of Rana catesbeiana. It has both lectin and ribonuclease (enzyme) properties, and therefore is called leczyme. We examined the antitumor effects of SBL and discovered that SBL has potential as a new type of anticancer drug. SBL causes a cancer-selective induction of apoptosis by multiple signaling pathways whereby RNA is its target. It is suggested that the mitochondrial pathway and endoplasmic reticulum stress-mediated pathway participate in SBL-induced signaling. The synergistic antitumor effects with other molecules, such as tumor necrosis factor-related apoptosis ligand (TRAIL) and interferon γ (IFN-γ), have been reported. In this study, we summarize the effects of SBL and focus on its cancer-selective apoptotic properties. In addition, we present a possible explanation its cancer specificity. |
topic |
Apoptosis leczyme cancer selectivity sialic acid-binding lectin cytotoxic ribonuclease |
url |
http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00139/full |
work_keys_str_mv |
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