Escherichia vulneris: an unusual cause of complicated diarrhoea and sepsis in an infant. A case report and review of literature
Escherichia vulneris is an opportunistic human pathogen. It has been primarily reported in adult patients and invasive infections have been observed in immune-suppressed individuals. This is the first report of E. vulneris causing complicated diarrhoea and sepsis in an infant. Two month old sick inf...
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doaj-39c36a41cc1c40628d9fd52b92fc2f322020-11-25T01:33:06ZengElsevierNew Microbes and New Infections2052-29752016-09-0113C838610.1016/j.nmni.2016.07.002Escherichia vulneris: an unusual cause of complicated diarrhoea and sepsis in an infant. A case report and review of literatureS. Jain0D. Nagarjuna1R. Gaind2S. Chopra3P.K. Debata4R. Dawar5R. Sardana6M. Yadav7Department of Microbiology, Vardhman Mahavir Medical College (VMMC) and Safdarjung Hospital, Delhi, IndiaDr. B.R. Ambedkar Centre for Biomedical Research (ACBR), University of Delhi, Delhi, IndiaDepartment of Microbiology, Vardhman Mahavir Medical College (VMMC) and Safdarjung Hospital, Delhi, IndiaDepartment of Microbiology, Vardhman Mahavir Medical College (VMMC) and Safdarjung Hospital, Delhi, IndiaDepartment of Paediatrics, Vardhman Mahavir Medical College (VMMC) and Safdarjung Hospital, Delhi, IndiaDepartment of Microbiology, Indraprastha Apollo Hospital, Sarita Vihar, New Delhi, IndiaDepartment of Microbiology, Indraprastha Apollo Hospital, Sarita Vihar, New Delhi, IndiaDr. B.R. Ambedkar Centre for Biomedical Research (ACBR), University of Delhi, Delhi, IndiaEscherichia vulneris is an opportunistic human pathogen. It has been primarily reported in adult patients and invasive infections have been observed in immune-suppressed individuals. This is the first report of E. vulneris causing complicated diarrhoea and sepsis in an infant. Two month old sick infant, born full-term, was admitted to the paediatrics department with loose motions and refusal to feed for four days. E. vulneris was isolated from blood in pure culture. The isolate was characterized for diarrhoeal virulence markers: heat labile and heat stable toxins (LT, ST) and hemolysin (hlyA) by PCR. The presence of LT enterotoxin and hemolysin provides strong evidence of the diarrhoeagenic potential of E. vulneris, further leading to the invasive infection triggering sepsis. As E. vulneris can lead to serious complications, an attempt should be made in clinical laboratories to identify and further characterize this new Escherichia species.http://www.sciencedirect.com/science/article/pii/S2052297516300737Complicated diarrhoeaEscherichia vulnerishemolysin (hlyA)infantLT toxinsepsis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
S. Jain D. Nagarjuna R. Gaind S. Chopra P.K. Debata R. Dawar R. Sardana M. Yadav |
spellingShingle |
S. Jain D. Nagarjuna R. Gaind S. Chopra P.K. Debata R. Dawar R. Sardana M. Yadav Escherichia vulneris: an unusual cause of complicated diarrhoea and sepsis in an infant. A case report and review of literature New Microbes and New Infections Complicated diarrhoea Escherichia vulneris hemolysin (hlyA) infant LT toxin sepsis |
author_facet |
S. Jain D. Nagarjuna R. Gaind S. Chopra P.K. Debata R. Dawar R. Sardana M. Yadav |
author_sort |
S. Jain |
title |
Escherichia vulneris: an unusual cause of complicated diarrhoea and sepsis in an infant. A case report and review of literature |
title_short |
Escherichia vulneris: an unusual cause of complicated diarrhoea and sepsis in an infant. A case report and review of literature |
title_full |
Escherichia vulneris: an unusual cause of complicated diarrhoea and sepsis in an infant. A case report and review of literature |
title_fullStr |
Escherichia vulneris: an unusual cause of complicated diarrhoea and sepsis in an infant. A case report and review of literature |
title_full_unstemmed |
Escherichia vulneris: an unusual cause of complicated diarrhoea and sepsis in an infant. A case report and review of literature |
title_sort |
escherichia vulneris: an unusual cause of complicated diarrhoea and sepsis in an infant. a case report and review of literature |
publisher |
Elsevier |
series |
New Microbes and New Infections |
issn |
2052-2975 |
publishDate |
2016-09-01 |
description |
Escherichia vulneris is an opportunistic human pathogen. It has been primarily reported in adult patients and invasive infections have been observed in immune-suppressed individuals. This is the first report of E. vulneris causing complicated diarrhoea and sepsis in an infant.
Two month old sick infant, born full-term, was admitted to the paediatrics department with loose motions and refusal to feed for four days. E. vulneris was isolated from blood in pure culture. The isolate was characterized for diarrhoeal virulence markers: heat labile and heat stable toxins (LT, ST) and hemolysin (hlyA) by PCR. The presence of LT enterotoxin and hemolysin provides strong evidence of the diarrhoeagenic potential of E. vulneris, further leading to the invasive infection triggering sepsis.
As E. vulneris can lead to serious complications, an attempt should be made in clinical laboratories to identify and further characterize this new Escherichia species. |
topic |
Complicated diarrhoea Escherichia vulneris hemolysin (hlyA) infant LT toxin sepsis |
url |
http://www.sciencedirect.com/science/article/pii/S2052297516300737 |
work_keys_str_mv |
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