The Protrusive Phase and Full Development of Integrin-Dependent Adhesions in Colon Epithelial Cells Require FAK- and ERKMediated Actin Spike Formation: Deregulation in Cancer Cells

The Protrusive Phase and Full Development of Integrin-Dependent Adhesions in Colon Epithelial Cells Require FAK- and ERKMediated Actin Spike Formation: Deregulation in Cancer Cells

Integrins play an important role in tumour progression by influencing cellular responses and matrix-dependent adhesion. However, the regulation of matrix-dependent adhesion assembly in epithelial cells is poorly understood. We have investigated the integrin and signalling requirements of cell-matri...

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Bibliographic Details
Main Authors: Valerie G. Brunton, Valerie J. Fincham, Gordon W. McLean, Steven J. Winder, Christos Paraskeva, John F. Marshall, Margaret C. Frame
Format: Article
Language:English
Published: Elsevier 2001-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
integrin-mediated adhesion assembly
colon cancer
focal adhesion kinase
extracellular signal-regulated kinase
actin cytoskeleton
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558601800452

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