Therapeutic effect of nucleoside analogs on experimental autoimmune encephalomyelitis in dark agouti rats

• Main Authors: Stojkov Danijela, Lavrnja Irena, Šubašić Sanja, Bjelobaba Ivana, Peković Sanja, Gađanski Ivana, Mostarica-Stojković Marija, Stošić-Grujičić Stanislava, Rakić Lj., Stojiljković Mirjana
• Format: Article
• Language: English
• Published: University of Belgrade, University of Novi Sad 2006-01-01
• Series: Archives of Biological Sciences
• Subjects: experimental autoimmune encephalomyelitis; multiple sclerosis; ribavirin; tiazofurin; therapeutic treatment
• Online Access: http://www.doiserbia.nb.rs/img/doi/0354-4664/2006/0354-46640601013S.pdf

Experimental autoimmune encephalomyelitis (EAE) is a commonly used animal model of the human neurological disorder multiple sclerosis. The purpose of the present study was to investigate the effect of combined treatment with two nucleoside analogs, ribavirin and tiazofurin, on development of EAE actively induced in highly susceptible dark agouti rats. The obtained results showed that ribavirin and tiazofurin applied either separately or in combination from the onset of the firstsymptoms of EAE after its induction (therapeutic treatment) significantly suppressed EAE’s clinical symptoms. However, the most pronounced effect was gained with combined treatment, probably as a result of synergistic/additive action.