Effect of fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol on the SIRS and target organ damage in patients with severe pneumonia complicated by respiratory failure
Objective: To study the effect of fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol on the systemic inflammatory response syndrome (SIRS) and target organ damage in patients with severe pneumonia complicated by respiratory failure. Methods: A total of 68 patients with severe pneumonia...
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Editorial Board of Journal of Hainan Medical University
2017-07-01
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doaj-39c6bcb5bdf442eabbe3b84dc63cd36a2020-11-25T00:26:13ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372017-07-012314912Effect of fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol on the SIRS and target organ damage in patients with severe pneumonia complicated by respiratory failureXiao-Jun Deng0Li-Ping Yang1Respiratory Department, Zigong Third People's Hospital in Sichuan Province, Zigong City, Sichuan Province, 643020Pharmacy Department, Zigong Third People's Hospital in Sichuan Province, Zigong City, Sichuan Province, 643020Objective: To study the effect of fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol on the systemic inflammatory response syndrome (SIRS) and target organ damage in patients with severe pneumonia complicated by respiratory failure. Methods: A total of 68 patients with severe pneumonia complicated by respiratory failure who received inpatient treatment in our hospital between July 2013 and December 2016 were collected and then divided into the control group (n=35) who received conventional therapy and the observation group (n=33) who received fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol + conventional therapy after the therapies were reviewed. The systemic inflammatory response as well as cardiac and liver function before and after treatment were compared between two groups of patients. Results: Before treatment, differences in serum levels of inflammatory factors, myocardial enzyme spectrum and liver function indexes were not statistically significant between the two groups of patients. After treatment, serum inflammatory factors IL-6, IL-8, TNF-毩 and CRP levels in observation group were lower than those in control group; serum myocardial enzyme spectrum LDH, α-HBDH, CKMB and cTnI levels were lower than those in control group; serum liver function index Alb content was higher than that in control group while ALP, TBA, ALT and AST contents were lower than those in control group. Conclusion: Fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol can effectively reduce the degree of SIRS, and also reduce the cardiac and liver function injury in patients with severe pneumonia complicated by respiratory failure.http://www.hnykdxxb.com/PDF/201714/3.pdfSevere pneumoniaRespiratory failureBronchoalveolar lavageInflammatory response |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiao-Jun Deng Li-Ping Yang |
spellingShingle |
Xiao-Jun Deng Li-Ping Yang Effect of fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol on the SIRS and target organ damage in patients with severe pneumonia complicated by respiratory failure Journal of Hainan Medical University Severe pneumonia Respiratory failure Bronchoalveolar lavage Inflammatory response |
author_facet |
Xiao-Jun Deng Li-Ping Yang |
author_sort |
Xiao-Jun Deng |
title |
Effect of fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol on the SIRS and target organ damage in patients with severe pneumonia complicated by respiratory failure |
title_short |
Effect of fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol on the SIRS and target organ damage in patients with severe pneumonia complicated by respiratory failure |
title_full |
Effect of fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol on the SIRS and target organ damage in patients with severe pneumonia complicated by respiratory failure |
title_fullStr |
Effect of fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol on the SIRS and target organ damage in patients with severe pneumonia complicated by respiratory failure |
title_full_unstemmed |
Effect of fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol on the SIRS and target organ damage in patients with severe pneumonia complicated by respiratory failure |
title_sort |
effect of fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol on the sirs and target organ damage in patients with severe pneumonia complicated by respiratory failure |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2017-07-01 |
description |
Objective: To study the effect of fiberoptic bronchoscopic bronchoalveolar lavage with
ambroxol on the systemic inflammatory response syndrome (SIRS) and target organ damage
in patients with severe pneumonia complicated by respiratory failure. Methods: A total of
68 patients with severe pneumonia complicated by respiratory failure who received inpatient
treatment in our hospital between July 2013 and December 2016 were collected and then
divided into the control group (n=35) who received conventional therapy and the observation
group (n=33) who received fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol +
conventional therapy after the therapies were reviewed. The systemic inflammatory response
as well as cardiac and liver function before and after treatment were compared between two
groups of patients. Results: Before treatment, differences in serum levels of inflammatory
factors, myocardial enzyme spectrum and liver function indexes were not statistically
significant between the two groups of patients. After treatment, serum inflammatory factors
IL-6, IL-8, TNF-毩 and CRP levels in observation group were lower than those in control
group; serum myocardial enzyme spectrum LDH, α-HBDH, CKMB and cTnI levels were
lower than those in control group; serum liver function index Alb content was higher than that
in control group while ALP, TBA, ALT and AST contents were lower than those in control
group. Conclusion: Fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol can
effectively reduce the degree of SIRS, and also reduce the cardiac and liver function injury in
patients with severe pneumonia complicated by respiratory failure. |
topic |
Severe pneumonia Respiratory failure Bronchoalveolar lavage Inflammatory response |
url |
http://www.hnykdxxb.com/PDF/201714/3.pdf |
work_keys_str_mv |
AT xiaojundeng effectoffiberopticbronchoscopicbronchoalveolarlavagewithambroxolonthesirsandtargetorgandamageinpatientswithseverepneumoniacomplicatedbyrespiratoryfailure AT lipingyang effectoffiberopticbronchoscopicbronchoalveolarlavagewithambroxolonthesirsandtargetorgandamageinpatientswithseverepneumoniacomplicatedbyrespiratoryfailure |
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1725345318487195648 |