The Use of Vasoactive Drugs in the Treatment of Male Erectile Dysfunction: Current Concepts
It is widely accepted that disorders of the male (uro)genital tract, such as erectile dysfunction (ED) and benign diseases of the prostate (lower urinary tract symptomatology or benign prostatic hyperplasia), can be approached therapeutically by influencing the function of both the vascular and non-...
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doaj-39dacecec0534272a966b7c6f283ac7c2020-11-25T03:41:20ZengMDPI AGJournal of Clinical Medicine2077-03832020-09-0192987298710.3390/jcm9092987The Use of Vasoactive Drugs in the Treatment of Male Erectile Dysfunction: Current ConceptsGeorge T. Kedia0Stefan Ückert1Dimitrios Tsikas2Armin J. Becker3Markus A. Kuczyk4Andreas Bannowsky5Department of Urology & Urological Oncology, Division of Surgery, Hannover Medical School, 30625 Hannover, GermanyDepartment of Urology & Urological Oncology, Division of Surgery, Hannover Medical School, 30625 Hannover, GermanyCenter of Pharmacology & Toxicology, Core Unit Proteomics, Hannover Medical School, 30625 Hannover, GermanyFaculty of Medicine, Academic Hospital Grosshadern, Department of Urology, Ludwig Maximilians University, 81377 Munich, GermanyDepartment of Urology & Urological Oncology, Division of Surgery, Hannover Medical School, 30625 Hannover, GermanyImland Hospital, Department of Urology, 24768 Rendsburg, GermanyIt is widely accepted that disorders of the male (uro)genital tract, such as erectile dysfunction (ED) and benign diseases of the prostate (lower urinary tract symptomatology or benign prostatic hyperplasia), can be approached therapeutically by influencing the function of both the vascular and non-vascular smooth muscle of the penile erectile tissue or the transition zone/periurethral region of the prostate, respectively. As a result of the discovery of nitric oxide (NO) and cyclic guanosine monophosphate (GMP) as central mediators of penile smooth muscle relaxation, the use of drugs known to increase the local production of NO and/or elevate the intracellular level of the second messenger cyclic GMP have attracted broad attention in the treatment of ED of various etiologies. Specifically, the introduction of vasoactive drugs, including orally active inhibitors of the cyclic GMP-specific phosphodiesterase (PDE) 5, has offered great advantage in the pharmacotherapy of ED and other diseases of the genitourinary tract. These drugs have been proven efficacious with a fast on-set of action and an improved profile of side-effects. This review summarizes current strategies for the treatment of ED utilizing the application of vasoactive drugs via the oral, transurethral, topical, or self-injection route.https://www.mdpi.com/2077-0383/9/9/2987erectile dysfunction (ED)drug treatmentvasoactive compoundsnitric oxide (NO)/cyclic guanosine monophosphate (cyclic GMP)cyclic adenosine monophosphate (cyclic AMP) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
George T. Kedia Stefan Ückert Dimitrios Tsikas Armin J. Becker Markus A. Kuczyk Andreas Bannowsky |
spellingShingle |
George T. Kedia Stefan Ückert Dimitrios Tsikas Armin J. Becker Markus A. Kuczyk Andreas Bannowsky The Use of Vasoactive Drugs in the Treatment of Male Erectile Dysfunction: Current Concepts Journal of Clinical Medicine erectile dysfunction (ED) drug treatment vasoactive compounds nitric oxide (NO)/cyclic guanosine monophosphate (cyclic GMP) cyclic adenosine monophosphate (cyclic AMP) |
author_facet |
George T. Kedia Stefan Ückert Dimitrios Tsikas Armin J. Becker Markus A. Kuczyk Andreas Bannowsky |
author_sort |
George T. Kedia |
title |
The Use of Vasoactive Drugs in the Treatment of Male Erectile Dysfunction: Current Concepts |
title_short |
The Use of Vasoactive Drugs in the Treatment of Male Erectile Dysfunction: Current Concepts |
title_full |
The Use of Vasoactive Drugs in the Treatment of Male Erectile Dysfunction: Current Concepts |
title_fullStr |
The Use of Vasoactive Drugs in the Treatment of Male Erectile Dysfunction: Current Concepts |
title_full_unstemmed |
The Use of Vasoactive Drugs in the Treatment of Male Erectile Dysfunction: Current Concepts |
title_sort |
use of vasoactive drugs in the treatment of male erectile dysfunction: current concepts |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-09-01 |
description |
It is widely accepted that disorders of the male (uro)genital tract, such as erectile dysfunction (ED) and benign diseases of the prostate (lower urinary tract symptomatology or benign prostatic hyperplasia), can be approached therapeutically by influencing the function of both the vascular and non-vascular smooth muscle of the penile erectile tissue or the transition zone/periurethral region of the prostate, respectively. As a result of the discovery of nitric oxide (NO) and cyclic guanosine monophosphate (GMP) as central mediators of penile smooth muscle relaxation, the use of drugs known to increase the local production of NO and/or elevate the intracellular level of the second messenger cyclic GMP have attracted broad attention in the treatment of ED of various etiologies. Specifically, the introduction of vasoactive drugs, including orally active inhibitors of the cyclic GMP-specific phosphodiesterase (PDE) 5, has offered great advantage in the pharmacotherapy of ED and other diseases of the genitourinary tract. These drugs have been proven efficacious with a fast on-set of action and an improved profile of side-effects. This review summarizes current strategies for the treatment of ED utilizing the application of vasoactive drugs via the oral, transurethral, topical, or self-injection route. |
topic |
erectile dysfunction (ED) drug treatment vasoactive compounds nitric oxide (NO)/cyclic guanosine monophosphate (cyclic GMP) cyclic adenosine monophosphate (cyclic AMP) |
url |
https://www.mdpi.com/2077-0383/9/9/2987 |
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