Toksisitas Senyawa Tembaga(II)Klorida Dihidrat Terhadap Sel Kanker Payudara T74D Secara in vitro

• Main Authors: Teguh Hari Sucipto, Harsasi Setyawati, Fahimah Martak
• Format: Article
• Language: Indonesian
• Published: Universitas Muhammadiyah Surabaya 2018-07-01
• Series: Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya
• Online Access: http://journal.um-surabaya.ac.id/index.php/qanunmedika/article/view/1433

Cancer is a normal cell transformation in the body becomes malignant due to the induction of carcinogens. Breast cancer is the second leading cause of death in Indonesia. The field of treatment with inorganic compounds has been widely developed and shows better anticancer activity than organic compounds. The aim of this research is to know the toxicity level of copper(II)chloride dihydrate compound was done by MTT method (3--4,5-dimethyltiazole-2-yl) -2,5-diphenyl-tetrazolium bromide} in vitro test of breast cancer cell T74D. Toxicity in copper(II)chloride dihydrate obtained IC50 value of 29.021 μg/ml. The value of IC50 obtained <100 μg/ml so that the copper(II)chloride dihydrate compound belongs to the category of medium toxicity compound (medium toxic). Copper is potentially toxic to cells, because copper charge can cause cell inactivation directly between metal-protein interactions.