Change and significance of serum inflammatory factors, NSE, S100 protein and stress hormone levels in patients with craniocerebral injury
Objective: To investigate the change and significance of serum inflammatory factors, neuron specific enolase (NSE), S100 protein and stress hormone levels in patients with brain diseases. Methods: A total of 115 patients with craniocerebral injury were selected as the observation group, according...
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doaj-39e3382e91fe4541b4a5c0e4e4cecb3a2020-11-25T00:24:42ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372017-09-012318152155Change and significance of serum inflammatory factors, NSE, S100 protein and stress hormone levels in patients with craniocerebral injuryRui-Feng Liu0Chang-Jiang Shu1Yang Shi2Department of Surgery, Civil Aviation Medical Center Chengdu, Sichuan, Chengdu 610200, ChinaDepartment of Surgery, Civil Aviation Medical Center Chengdu, Sichuan, Chengdu 610200, ChinaDepartment of Surgery, Civil Aviation Medical Center Chengdu, Sichuan, Chengdu 610200, ChinaObjective: To investigate the change and significance of serum inflammatory factors, neuron specific enolase (NSE), S100 protein and stress hormone levels in patients with brain diseases. Methods: A total of 115 patients with craniocerebral injury were selected as the observation group, according to the Glasgow Coma Scale (GCS), they were divided into light-sized group (n=38), middle-sized group (n=40) and severe-sized group (n=37), at the same time the other 120 healthy subjects were selected as the control group. The levels of serum inflammatory cytokines [tumor necrosis factor alpha (TNF-α) and procalcitonin (PCT)], neuron specific enolase (NSE), S100 protein and the stress hormone cortisol [(COR), adrenocorticotropic hormone (ACTH), β-endorphin (β-EP)] of both groups were compared. Results: The levels of TNF-α, PCT, NSE, S100, COR, ACTH and β-EP in the observation group were (145.73±19.24) ng/L, (2.41±0.64) ng/mL, (38.11±12.28) ng/mL, (0.87±0.32) μg/L, (818.87±121.14) nmol/L, (107.38±13.94) ng/L, (126.74±39.04) ng/mL, which were significantly higher than control group, the difference was statistically significant; Comparison of indexes among the observation group, NF-α, PCT, NSE, S100, COR, ACTH and β-EP levels in the middle-sized group and severe-sized group were significantly higher than those in the light-sized group, and the levels in the severe-sized group were significantly higher than those of the middle-sized group, the difference was statistically significant. Conclusion: The levels of Serum inflammatory factors, NSE, S100 protein and stress hormone were significantly increased in patients with craniocerebral injury, the level was related to the degree of traumatic brain injury, which could be used as an important indicator to assess the severity of the disease.http://www.hnykdxxb.com/PDF/201718/37.pdfCraniocerebral traumaInflammatory factorsNSES100 proteinStress hormone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rui-Feng Liu Chang-Jiang Shu Yang Shi |
spellingShingle |
Rui-Feng Liu Chang-Jiang Shu Yang Shi Change and significance of serum inflammatory factors, NSE, S100 protein and stress hormone levels in patients with craniocerebral injury Journal of Hainan Medical University Craniocerebral trauma Inflammatory factors NSE S100 protein Stress hormone |
author_facet |
Rui-Feng Liu Chang-Jiang Shu Yang Shi |
author_sort |
Rui-Feng Liu |
title |
Change and significance of serum inflammatory factors, NSE, S100 protein and stress hormone levels in patients with craniocerebral injury |
title_short |
Change and significance of serum inflammatory factors, NSE, S100 protein and stress hormone levels in patients with craniocerebral injury |
title_full |
Change and significance of serum inflammatory factors, NSE, S100 protein and stress hormone levels in patients with craniocerebral injury |
title_fullStr |
Change and significance of serum inflammatory factors, NSE, S100 protein and stress hormone levels in patients with craniocerebral injury |
title_full_unstemmed |
Change and significance of serum inflammatory factors, NSE, S100 protein and stress hormone levels in patients with craniocerebral injury |
title_sort |
change and significance of serum inflammatory factors, nse, s100 protein and stress hormone levels in patients with craniocerebral injury |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2017-09-01 |
description |
Objective: To investigate the change and significance of serum inflammatory factors,
neuron specific enolase (NSE), S100 protein and stress hormone levels in patients with
brain diseases. Methods: A total of 115 patients with craniocerebral injury were selected
as the observation group, according to the Glasgow Coma Scale (GCS), they were divided
into light-sized group (n=38), middle-sized group (n=40) and severe-sized group (n=37), at
the same time the other 120 healthy subjects were selected as the control group. The levels
of serum inflammatory cytokines [tumor necrosis factor alpha (TNF-α) and procalcitonin
(PCT)], neuron specific enolase (NSE), S100 protein and the stress hormone cortisol [(COR),
adrenocorticotropic hormone (ACTH), β-endorphin (β-EP)] of both groups were compared.
Results: The levels of TNF-α, PCT, NSE, S100, COR, ACTH and β-EP in the observation
group were (145.73±19.24) ng/L, (2.41±0.64) ng/mL, (38.11±12.28) ng/mL, (0.87±0.32)
μg/L, (818.87±121.14) nmol/L, (107.38±13.94) ng/L, (126.74±39.04) ng/mL, which were
significantly higher than control group, the difference was statistically significant; Comparison
of indexes among the observation group, NF-α, PCT, NSE, S100, COR, ACTH and β-EP
levels in the middle-sized group and severe-sized group were significantly higher than those
in the light-sized group, and the levels in the severe-sized group were significantly higher
than those of the middle-sized group, the difference was statistically significant. Conclusion:
The levels of Serum inflammatory factors, NSE, S100 protein and stress hormone were
significantly increased in patients with craniocerebral injury, the level was related to the degree
of traumatic brain injury, which could be used as an important indicator to assess the severity
of the disease. |
topic |
Craniocerebral trauma Inflammatory factors NSE S100 protein Stress hormone |
url |
http://www.hnykdxxb.com/PDF/201718/37.pdf |
work_keys_str_mv |
AT ruifengliu changeandsignificanceofseruminflammatoryfactorsnses100proteinandstresshormonelevelsinpatientswithcraniocerebralinjury AT changjiangshu changeandsignificanceofseruminflammatoryfactorsnses100proteinandstresshormonelevelsinpatientswithcraniocerebralinjury AT yangshi changeandsignificanceofseruminflammatoryfactorsnses100proteinandstresshormonelevelsinpatientswithcraniocerebralinjury |
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1725352304365797376 |