Cardiovascular Risk and Hippocampal Thickness in Alzheimer’s Disease
Cardiovascular risk factors influence onset and progression of Alzheimer’s disease. Among cognitively healthy people, changes in brain structure and function associated with high blood pressure, diabetes, or other vascular risks suggest differential regional susceptibility to neuronal damage. In pat...
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Series: | International Journal of Alzheimer's Disease |
Online Access: | http://dx.doi.org/10.1155/2013/108021 |
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doaj-39e3456b8dbb49a284e6a12330198fb62020-11-24T23:19:48ZengHindawi LimitedInternational Journal of Alzheimer's Disease2090-80242090-02522013-01-01201310.1155/2013/108021108021Cardiovascular Risk and Hippocampal Thickness in Alzheimer’s DiseaseMarkus Donix0Maria Scharf1Kira Marschner2Annett Werner3Cathrin Sauer4Antje Gerner5Josef A. Nees6Shirin Meyer7Katharina L. Donix8Rüdiger Von Kummer9Vjera A. Holthoff10Department of Psychiatry and Psychotherapy, Division of Old Age Psychiatry and Cognitive Neuropsychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Psychiatry and Psychotherapy, Division of Old Age Psychiatry and Cognitive Neuropsychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Psychiatry and Psychotherapy, Division of Old Age Psychiatry and Cognitive Neuropsychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Neuroradiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Psychiatry and Psychotherapy, Division of Old Age Psychiatry and Cognitive Neuropsychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Psychiatry and Psychotherapy, Division of Old Age Psychiatry and Cognitive Neuropsychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Psychiatry and Psychotherapy, Division of Old Age Psychiatry and Cognitive Neuropsychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Psychiatry and Psychotherapy, Division of Old Age Psychiatry and Cognitive Neuropsychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Psychiatry and Psychotherapy, Division of Old Age Psychiatry and Cognitive Neuropsychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Neuroradiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Psychiatry and Psychotherapy, Division of Old Age Psychiatry and Cognitive Neuropsychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, GermanyCardiovascular risk factors influence onset and progression of Alzheimer’s disease. Among cognitively healthy people, changes in brain structure and function associated with high blood pressure, diabetes, or other vascular risks suggest differential regional susceptibility to neuronal damage. In patients with Alzheimer’s disease, hippocampal and medial temporal lobe atrophy indicate early neuronal loss preferentially in key areas for learning and memory. We wanted to investigate whether this regional cortical thinning would be modulated by cardiovascular risk factors. We utilized high-resolution magnetic resonance imaging and a cortical unfolding technique to determine the cortical thickness of medial temporal subregions in 30 patients with Alzheimer’s disease. Cardiovascular risk was assessed using a sex-specific multivariable risk score. Greater cardiovascular risk was associated with cortical thinning in the hippocampus CA2/3/dentate gyrus area but not other hippocampal and medial temporal subregions. APOE genotype, a family history of Alzheimer’s disease, and age did not influence cortical thickness. Alzheimer’s disease-related atrophy could mask the influence of genetic risk factors or age on regional cortical thickness in medial temporal lobe regions, whereas the impact of vascular risk factors remains detectable. This highlights the importance of cardiovascular disease prevention and treatment in patients with Alzheimer’s disease.http://dx.doi.org/10.1155/2013/108021 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Markus Donix Maria Scharf Kira Marschner Annett Werner Cathrin Sauer Antje Gerner Josef A. Nees Shirin Meyer Katharina L. Donix Rüdiger Von Kummer Vjera A. Holthoff |
spellingShingle |
Markus Donix Maria Scharf Kira Marschner Annett Werner Cathrin Sauer Antje Gerner Josef A. Nees Shirin Meyer Katharina L. Donix Rüdiger Von Kummer Vjera A. Holthoff Cardiovascular Risk and Hippocampal Thickness in Alzheimer’s Disease International Journal of Alzheimer's Disease |
author_facet |
Markus Donix Maria Scharf Kira Marschner Annett Werner Cathrin Sauer Antje Gerner Josef A. Nees Shirin Meyer Katharina L. Donix Rüdiger Von Kummer Vjera A. Holthoff |
author_sort |
Markus Donix |
title |
Cardiovascular Risk and Hippocampal Thickness in Alzheimer’s Disease |
title_short |
Cardiovascular Risk and Hippocampal Thickness in Alzheimer’s Disease |
title_full |
Cardiovascular Risk and Hippocampal Thickness in Alzheimer’s Disease |
title_fullStr |
Cardiovascular Risk and Hippocampal Thickness in Alzheimer’s Disease |
title_full_unstemmed |
Cardiovascular Risk and Hippocampal Thickness in Alzheimer’s Disease |
title_sort |
cardiovascular risk and hippocampal thickness in alzheimer’s disease |
publisher |
Hindawi Limited |
series |
International Journal of Alzheimer's Disease |
issn |
2090-8024 2090-0252 |
publishDate |
2013-01-01 |
description |
Cardiovascular risk factors influence onset and progression of Alzheimer’s disease. Among cognitively healthy people, changes in brain structure and function associated with high blood pressure, diabetes, or other vascular risks suggest differential regional susceptibility to neuronal damage. In patients with Alzheimer’s disease, hippocampal and medial temporal lobe atrophy indicate early neuronal loss preferentially in key areas for learning and memory. We wanted to investigate whether this regional cortical thinning would be modulated by cardiovascular risk factors. We utilized high-resolution magnetic resonance imaging and a cortical unfolding technique to determine the cortical thickness of medial temporal subregions in 30 patients with Alzheimer’s disease. Cardiovascular risk was assessed using a sex-specific multivariable risk score. Greater cardiovascular risk was associated with cortical thinning in the hippocampus CA2/3/dentate gyrus area but not other hippocampal and medial temporal subregions. APOE genotype, a family history of Alzheimer’s disease, and age did not influence cortical thickness. Alzheimer’s disease-related atrophy could mask the influence of genetic risk factors or age on regional cortical thickness in medial temporal lobe regions, whereas the impact of vascular risk factors remains detectable. This highlights the importance of cardiovascular disease prevention and treatment in patients with Alzheimer’s disease. |
url |
http://dx.doi.org/10.1155/2013/108021 |
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