Pathomorphological features of parathyroid glands in secondary and tertiary hyperparathyroidism

• Main Authors: Tkachenko R.P., Kurik E.G., Gubar A.S., Belemets N.I.
• Format: Article
• Language: Russian
• Published: Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy 2014-06-01
• Series: Морфологія
• Subjects: parathyroid glands; secondary hyperparathyroidism; tertiary hyperparathyroidism; microadenomatosis; adenoma
• Online Access: http://www.morphology.dp.ua/_pub/MORPHO-2014-08-02/14trpvtg.pdf

Background. Morphological methods of diagnosis in patients with secondary and tertiary hyperparathyroidism are very important, especially in the intraoperative and postoperative stages. In the end only able to detect microscopic examination microadenomatosis and macroadenomatosis of parathyroid glands, which are characteristic of tertiary hyperparathyroidism form. Intraoperative research of frozen sections allows to match of a similar macroscopic signs of external structures (parathyroid gland, thyroid gland, lymph node, fat, thymus) tissue is parathyroid glands. Objective. Aim – to research the morfhological features of parathyroid glands in secondary and tertiary hyperparathyroidism. Methods. The morphological features of parathyroid glands in 31 patients with secondary and tertiary hyperparathyroidism were studied. Results. Parathyroid hyperplasia – 4 cases (13%), nodulus hyperplasia (microadenoma) – 7 (22%) and parathyroid adenoma (more than 5 mm diameter) – 20 cases (65%) were found. Conclusion. In the most of parathyroid glands in secondary hyperparathyroidism we found the eadenomatous changes of gland parenchyma such as micro- and macroadenomatosis. Macroadenomas were observed in 2/3 cases that that testifies to passing of secondary hyperparathyroidism to tertiary hyperparathyroidism. Citation: Tkachenko RP, Kurik EG, Gubar AS, Belemets NI. [Pathomorphological features of parathyroid glands in secondary and tertiary hyperparathyroidism]. Morphologia. 2014;8(2):67-71. Ukrainian.