The U-Shaped Association Between Serum Uric Acid and Red Blood Cell Distribution Width in Acute Ischemic Stroke
Objective: The U-shaped association between serum uric acid (SUA) and the functional outcome has been found in acute ischemic stroke (AIS). However, it is unclear if SUA is associated with red blood cell morphology in AIS. This study aimed to determine the relationship between SUA and red blood cell...
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2021-08-01
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doaj-39f92bb94fbc48c6800f73557fdd9fdd2021-08-03T06:13:38ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-08-011210.3389/fphys.2021.631369631369The U-Shaped Association Between Serum Uric Acid and Red Blood Cell Distribution Width in Acute Ischemic StrokeNing Rong0Ning Rong1Pei Zhao2Jin Yang3Qing-Lei Fan4Qiang Zhang5Zhi-Gang Han6Jian Cai7Jian Cai8De-Sheng Zhu9De-Sheng Zhu10Department of Neurology, Baoshan Branch, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaSchool of Clinical Medicine, Dali University, Dali, ChinaDepartment of Neurology, Baoshan Branch, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Neurology, Baoshan Branch, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Neurology, Baoshan Branch, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaSchool of Clinical Medicine, Dali University, Dali, ChinaDepartment of Radiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaDepartment of Neurology, Baoshan Branch, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Neurology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Neurology, Baoshan Branch, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Neurology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaObjective: The U-shaped association between serum uric acid (SUA) and the functional outcome has been found in acute ischemic stroke (AIS). However, it is unclear if SUA is associated with red blood cell morphology in AIS. This study aimed to determine the relationship between SUA and red blood cell distribution width (RDW) in patients with AIS.Methods: A cross-sectional study including 438 consecutive patients with AIS was conducted. SUA and RDW, biochemical parameters that reflect the heterogeneity of red blood cell volume, were evaluated on admission. We evaluated the association between SUA and RDW through linear curve fitting analyses and two-piecewise regression analyses.Results: The association between SUA levels and RDW followed a U-shape in all patients. In females, the values of RDW significantly decreased with the increment of SUA (per mg/dl: β, −1.45; 95% CI: −2.15 to −0.75; p < 0.001) in patients with SUA <3.86 mg/dl and increased with the increment of SUA (per mg/dl: β, 0.60; 95% CI: 0.22–0.97; p = 0.002) in patients with SUA ≥ 3.86 mg/dl. Similar results were observed in males with the turning point of SUA = 4.82 mg/dl. After adjusting for potential confounders, a U-shaped association between SUA and RDW was maintained in females, but no statistical significance was maintained in patients with SUA ≥ 4.82 mg/dl in males (p = 0.206).Conclusion: In the sample of patients with AIS, we found a U-shaped relationship between SUA levels and RDW, with the turning point of SUA (3.96 mg/dl in females and 4.82 mg/dl in males) by the threshold effect analysis.https://www.frontiersin.org/articles/10.3389/fphys.2021.631369/fullacute ischemic strokered blood cell distribution widthserum uric aciduric acidtwo-piecewise regression analyses |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ning Rong Ning Rong Pei Zhao Jin Yang Qing-Lei Fan Qiang Zhang Zhi-Gang Han Jian Cai Jian Cai De-Sheng Zhu De-Sheng Zhu |
spellingShingle |
Ning Rong Ning Rong Pei Zhao Jin Yang Qing-Lei Fan Qiang Zhang Zhi-Gang Han Jian Cai Jian Cai De-Sheng Zhu De-Sheng Zhu The U-Shaped Association Between Serum Uric Acid and Red Blood Cell Distribution Width in Acute Ischemic Stroke Frontiers in Physiology acute ischemic stroke red blood cell distribution width serum uric acid uric acid two-piecewise regression analyses |
author_facet |
Ning Rong Ning Rong Pei Zhao Jin Yang Qing-Lei Fan Qiang Zhang Zhi-Gang Han Jian Cai Jian Cai De-Sheng Zhu De-Sheng Zhu |
author_sort |
Ning Rong |
title |
The U-Shaped Association Between Serum Uric Acid and Red Blood Cell Distribution Width in Acute Ischemic Stroke |
title_short |
The U-Shaped Association Between Serum Uric Acid and Red Blood Cell Distribution Width in Acute Ischemic Stroke |
title_full |
The U-Shaped Association Between Serum Uric Acid and Red Blood Cell Distribution Width in Acute Ischemic Stroke |
title_fullStr |
The U-Shaped Association Between Serum Uric Acid and Red Blood Cell Distribution Width in Acute Ischemic Stroke |
title_full_unstemmed |
The U-Shaped Association Between Serum Uric Acid and Red Blood Cell Distribution Width in Acute Ischemic Stroke |
title_sort |
u-shaped association between serum uric acid and red blood cell distribution width in acute ischemic stroke |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2021-08-01 |
description |
Objective: The U-shaped association between serum uric acid (SUA) and the functional outcome has been found in acute ischemic stroke (AIS). However, it is unclear if SUA is associated with red blood cell morphology in AIS. This study aimed to determine the relationship between SUA and red blood cell distribution width (RDW) in patients with AIS.Methods: A cross-sectional study including 438 consecutive patients with AIS was conducted. SUA and RDW, biochemical parameters that reflect the heterogeneity of red blood cell volume, were evaluated on admission. We evaluated the association between SUA and RDW through linear curve fitting analyses and two-piecewise regression analyses.Results: The association between SUA levels and RDW followed a U-shape in all patients. In females, the values of RDW significantly decreased with the increment of SUA (per mg/dl: β, −1.45; 95% CI: −2.15 to −0.75; p < 0.001) in patients with SUA <3.86 mg/dl and increased with the increment of SUA (per mg/dl: β, 0.60; 95% CI: 0.22–0.97; p = 0.002) in patients with SUA ≥ 3.86 mg/dl. Similar results were observed in males with the turning point of SUA = 4.82 mg/dl. After adjusting for potential confounders, a U-shaped association between SUA and RDW was maintained in females, but no statistical significance was maintained in patients with SUA ≥ 4.82 mg/dl in males (p = 0.206).Conclusion: In the sample of patients with AIS, we found a U-shaped relationship between SUA levels and RDW, with the turning point of SUA (3.96 mg/dl in females and 4.82 mg/dl in males) by the threshold effect analysis. |
topic |
acute ischemic stroke red blood cell distribution width serum uric acid uric acid two-piecewise regression analyses |
url |
https://www.frontiersin.org/articles/10.3389/fphys.2021.631369/full |
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