The U-Shaped Association Between Serum Uric Acid and Red Blood Cell Distribution Width in Acute Ischemic Stroke

Objective: The U-shaped association between serum uric acid (SUA) and the functional outcome has been found in acute ischemic stroke (AIS). However, it is unclear if SUA is associated with red blood cell morphology in AIS. This study aimed to determine the relationship between SUA and red blood cell...

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Main Authors: Ning Rong, Pei Zhao, Jin Yang, Qing-Lei Fan, Qiang Zhang, Zhi-Gang Han, Jian Cai, De-Sheng Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Physiology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.631369/full
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spelling doaj-39f92bb94fbc48c6800f73557fdd9fdd2021-08-03T06:13:38ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-08-011210.3389/fphys.2021.631369631369The U-Shaped Association Between Serum Uric Acid and Red Blood Cell Distribution Width in Acute Ischemic StrokeNing Rong0Ning Rong1Pei Zhao2Jin Yang3Qing-Lei Fan4Qiang Zhang5Zhi-Gang Han6Jian Cai7Jian Cai8De-Sheng Zhu9De-Sheng Zhu10Department of Neurology, Baoshan Branch, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaSchool of Clinical Medicine, Dali University, Dali, ChinaDepartment of Neurology, Baoshan Branch, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Neurology, Baoshan Branch, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Neurology, Baoshan Branch, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaSchool of Clinical Medicine, Dali University, Dali, ChinaDepartment of Radiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaDepartment of Neurology, Baoshan Branch, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Neurology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Neurology, Baoshan Branch, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Neurology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaObjective: The U-shaped association between serum uric acid (SUA) and the functional outcome has been found in acute ischemic stroke (AIS). However, it is unclear if SUA is associated with red blood cell morphology in AIS. This study aimed to determine the relationship between SUA and red blood cell distribution width (RDW) in patients with AIS.Methods: A cross-sectional study including 438 consecutive patients with AIS was conducted. SUA and RDW, biochemical parameters that reflect the heterogeneity of red blood cell volume, were evaluated on admission. We evaluated the association between SUA and RDW through linear curve fitting analyses and two-piecewise regression analyses.Results: The association between SUA levels and RDW followed a U-shape in all patients. In females, the values of RDW significantly decreased with the increment of SUA (per mg/dl: β, −1.45; 95% CI: −2.15 to −0.75; p < 0.001) in patients with SUA <3.86 mg/dl and increased with the increment of SUA (per mg/dl: β, 0.60; 95% CI: 0.22–0.97; p = 0.002) in patients with SUA ≥ 3.86 mg/dl. Similar results were observed in males with the turning point of SUA = 4.82 mg/dl. After adjusting for potential confounders, a U-shaped association between SUA and RDW was maintained in females, but no statistical significance was maintained in patients with SUA ≥ 4.82 mg/dl in males (p = 0.206).Conclusion: In the sample of patients with AIS, we found a U-shaped relationship between SUA levels and RDW, with the turning point of SUA (3.96 mg/dl in females and 4.82 mg/dl in males) by the threshold effect analysis.https://www.frontiersin.org/articles/10.3389/fphys.2021.631369/fullacute ischemic strokered blood cell distribution widthserum uric aciduric acidtwo-piecewise regression analyses
collection DOAJ
language English
format Article
sources DOAJ
author Ning Rong
Ning Rong
Pei Zhao
Jin Yang
Qing-Lei Fan
Qiang Zhang
Zhi-Gang Han
Jian Cai
Jian Cai
De-Sheng Zhu
De-Sheng Zhu
spellingShingle Ning Rong
Ning Rong
Pei Zhao
Jin Yang
Qing-Lei Fan
Qiang Zhang
Zhi-Gang Han
Jian Cai
Jian Cai
De-Sheng Zhu
De-Sheng Zhu
The U-Shaped Association Between Serum Uric Acid and Red Blood Cell Distribution Width in Acute Ischemic Stroke
Frontiers in Physiology
acute ischemic stroke
red blood cell distribution width
serum uric acid
uric acid
two-piecewise regression analyses
author_facet Ning Rong
Ning Rong
Pei Zhao
Jin Yang
Qing-Lei Fan
Qiang Zhang
Zhi-Gang Han
Jian Cai
Jian Cai
De-Sheng Zhu
De-Sheng Zhu
author_sort Ning Rong
title The U-Shaped Association Between Serum Uric Acid and Red Blood Cell Distribution Width in Acute Ischemic Stroke
title_short The U-Shaped Association Between Serum Uric Acid and Red Blood Cell Distribution Width in Acute Ischemic Stroke
title_full The U-Shaped Association Between Serum Uric Acid and Red Blood Cell Distribution Width in Acute Ischemic Stroke
title_fullStr The U-Shaped Association Between Serum Uric Acid and Red Blood Cell Distribution Width in Acute Ischemic Stroke
title_full_unstemmed The U-Shaped Association Between Serum Uric Acid and Red Blood Cell Distribution Width in Acute Ischemic Stroke
title_sort u-shaped association between serum uric acid and red blood cell distribution width in acute ischemic stroke
publisher Frontiers Media S.A.
series Frontiers in Physiology
issn 1664-042X
publishDate 2021-08-01
description Objective: The U-shaped association between serum uric acid (SUA) and the functional outcome has been found in acute ischemic stroke (AIS). However, it is unclear if SUA is associated with red blood cell morphology in AIS. This study aimed to determine the relationship between SUA and red blood cell distribution width (RDW) in patients with AIS.Methods: A cross-sectional study including 438 consecutive patients with AIS was conducted. SUA and RDW, biochemical parameters that reflect the heterogeneity of red blood cell volume, were evaluated on admission. We evaluated the association between SUA and RDW through linear curve fitting analyses and two-piecewise regression analyses.Results: The association between SUA levels and RDW followed a U-shape in all patients. In females, the values of RDW significantly decreased with the increment of SUA (per mg/dl: β, −1.45; 95% CI: −2.15 to −0.75; p < 0.001) in patients with SUA <3.86 mg/dl and increased with the increment of SUA (per mg/dl: β, 0.60; 95% CI: 0.22–0.97; p = 0.002) in patients with SUA ≥ 3.86 mg/dl. Similar results were observed in males with the turning point of SUA = 4.82 mg/dl. After adjusting for potential confounders, a U-shaped association between SUA and RDW was maintained in females, but no statistical significance was maintained in patients with SUA ≥ 4.82 mg/dl in males (p = 0.206).Conclusion: In the sample of patients with AIS, we found a U-shaped relationship between SUA levels and RDW, with the turning point of SUA (3.96 mg/dl in females and 4.82 mg/dl in males) by the threshold effect analysis.
topic acute ischemic stroke
red blood cell distribution width
serum uric acid
uric acid
two-piecewise regression analyses
url https://www.frontiersin.org/articles/10.3389/fphys.2021.631369/full
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