X chromosome dosage and presence of SRY shape sex-specific differences in DNA methylation at an autosomal region in human cells

X chromosome dosage and presence of SRY shape sex-specific differences in DNA methylation at an autosomal region in human cells

Abstract Background Sexual dimorphism in DNA methylation levels is a recurrent epigenetic feature in different human cell types and has been implicated in predisposition to disease, such as psychiatric and autoimmune disorders. To elucidate the genetic origins of sex-specific DNA methylation, we exa...

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Bibliographic Details
Main Authors: Bianca Ho, Keelin Greenlaw, Abeer Al Tuwaijri, Sanny Moussette, Francisco Martínez, Elisa Giorgio, Alfredo Brusco, Giovanni Battista Ferrero, Natália D. Linhares, Eugênia R. Valadares, Marta Svartman, Vera M. Kalscheuer, Germán Rodríguez Criado, Catherine Laprise, Celia M. T. Greenwood, Anna K. Naumova
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Biology of Sex Differences
Subjects:
DNA methylation
Sex
X chromosome
Y chromosome
Online Access:http://link.springer.com/article/10.1186/s13293-018-0169-7

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