Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature

Abstract Background Human parechovirus type 3 (HPeV-3) is known to cause cold-like symptoms, diarrhea, or severe infections such as sepsis in infants and children. In adults, HPeV-3 infection is rarely diagnosed because the symptoms are generally mild and self-limiting; however, this infection has b...

Full description

Bibliographic Details
Main Authors: Kiwamu Nakamura, Kyoichi Saito, Yasuka Hara, Tetsuji Aoyagi, Kadzuhiro Kitakawa, Yoshinobu Abe, Hiromu Takemura, Fumihito Ikeda, Mitsuo Kaku, Keiji Kanemitsu
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Infectious Diseases
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12879-018-3284-5
id doaj-39fcde3480b54bd68d5a10a711885485
record_format Article
spelling doaj-39fcde3480b54bd68d5a10a7118854852020-11-25T03:38:18ZengBMCBMC Infectious Diseases1471-23342018-08-011811510.1186/s12879-018-3284-5Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literatureKiwamu Nakamura0Kyoichi Saito1Yasuka Hara2Tetsuji Aoyagi3Kadzuhiro Kitakawa4Yoshinobu Abe5Hiromu Takemura6Fumihito Ikeda7Mitsuo Kaku8Keiji Kanemitsu9Department of Infection Control, Fukushima Medical UniversityDepartment of Infection Control, Fukushima Medical UniversityDepartment of Infection Control, Fukushima Medical UniversityDepartment of Infection Control and Laboratory Diagnostics, Tohoku University Graduate School of MedicineDepartment of Microbiology, Fukushima Prefectural Institute of Public HealthDepartment of Infection Control, Fukushima Medical UniversityDepartment of Microbiology, St. Marianna University School of MedicineIkeda Memorial HospitalDepartment of Infection Control and Laboratory Diagnostics, Tohoku University Graduate School of MedicineDepartment of Infection Control, Fukushima Medical UniversityAbstract Background Human parechovirus type 3 (HPeV-3) is known to cause cold-like symptoms, diarrhea, or severe infections such as sepsis in infants and children. In adults, HPeV-3 infection is rarely diagnosed because the symptoms are generally mild and self-limiting; however, this infection has been linked to epidemic myalgia, regardless of the presence of underlying diseases, immunosuppression, or sex. Case presentation We describe an adult case of severe systemic myalgia and orchiodynia after infection with HPeV-3, which was transmitted from the child of the patient. Interleukin-6 (IL-6) level was found to be elevated in the patient’s serum. Conclusion Severe myalgia associated with HPeV-3 infection is potentially caused by an elevated serum level of IL-6.http://link.springer.com/article/10.1186/s12879-018-3284-5Human parechovirus type 3Epidemic myalgiaOrchiodyniaIL-6
collection DOAJ
language English
format Article
sources DOAJ
author Kiwamu Nakamura
Kyoichi Saito
Yasuka Hara
Tetsuji Aoyagi
Kadzuhiro Kitakawa
Yoshinobu Abe
Hiromu Takemura
Fumihito Ikeda
Mitsuo Kaku
Keiji Kanemitsu
spellingShingle Kiwamu Nakamura
Kyoichi Saito
Yasuka Hara
Tetsuji Aoyagi
Kadzuhiro Kitakawa
Yoshinobu Abe
Hiromu Takemura
Fumihito Ikeda
Mitsuo Kaku
Keiji Kanemitsu
Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature
BMC Infectious Diseases
Human parechovirus type 3
Epidemic myalgia
Orchiodynia
IL-6
author_facet Kiwamu Nakamura
Kyoichi Saito
Yasuka Hara
Tetsuji Aoyagi
Kadzuhiro Kitakawa
Yoshinobu Abe
Hiromu Takemura
Fumihito Ikeda
Mitsuo Kaku
Keiji Kanemitsu
author_sort Kiwamu Nakamura
title Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature
title_short Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature
title_full Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature
title_fullStr Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature
title_full_unstemmed Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature
title_sort severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature
publisher BMC
series BMC Infectious Diseases
issn 1471-2334
publishDate 2018-08-01
description Abstract Background Human parechovirus type 3 (HPeV-3) is known to cause cold-like symptoms, diarrhea, or severe infections such as sepsis in infants and children. In adults, HPeV-3 infection is rarely diagnosed because the symptoms are generally mild and self-limiting; however, this infection has been linked to epidemic myalgia, regardless of the presence of underlying diseases, immunosuppression, or sex. Case presentation We describe an adult case of severe systemic myalgia and orchiodynia after infection with HPeV-3, which was transmitted from the child of the patient. Interleukin-6 (IL-6) level was found to be elevated in the patient’s serum. Conclusion Severe myalgia associated with HPeV-3 infection is potentially caused by an elevated serum level of IL-6.
topic Human parechovirus type 3
Epidemic myalgia
Orchiodynia
IL-6
url http://link.springer.com/article/10.1186/s12879-018-3284-5
work_keys_str_mv AT kiwamunakamura severeepidemicmyalgiawithanelevatedlevelofseruminterleukin6causedbyhumanparechovirustype3acasereportandbriefreviewoftheliterature
AT kyoichisaito severeepidemicmyalgiawithanelevatedlevelofseruminterleukin6causedbyhumanparechovirustype3acasereportandbriefreviewoftheliterature
AT yasukahara severeepidemicmyalgiawithanelevatedlevelofseruminterleukin6causedbyhumanparechovirustype3acasereportandbriefreviewoftheliterature
AT tetsujiaoyagi severeepidemicmyalgiawithanelevatedlevelofseruminterleukin6causedbyhumanparechovirustype3acasereportandbriefreviewoftheliterature
AT kadzuhirokitakawa severeepidemicmyalgiawithanelevatedlevelofseruminterleukin6causedbyhumanparechovirustype3acasereportandbriefreviewoftheliterature
AT yoshinobuabe severeepidemicmyalgiawithanelevatedlevelofseruminterleukin6causedbyhumanparechovirustype3acasereportandbriefreviewoftheliterature
AT hiromutakemura severeepidemicmyalgiawithanelevatedlevelofseruminterleukin6causedbyhumanparechovirustype3acasereportandbriefreviewoftheliterature
AT fumihitoikeda severeepidemicmyalgiawithanelevatedlevelofseruminterleukin6causedbyhumanparechovirustype3acasereportandbriefreviewoftheliterature
AT mitsuokaku severeepidemicmyalgiawithanelevatedlevelofseruminterleukin6causedbyhumanparechovirustype3acasereportandbriefreviewoftheliterature
AT keijikanemitsu severeepidemicmyalgiawithanelevatedlevelofseruminterleukin6causedbyhumanparechovirustype3acasereportandbriefreviewoftheliterature
_version_ 1724542920751579136