Serum Antioxidant Associations with Metabolic Characteristics in Metabolically Healthy and Unhealthy Adolescents with Severe Obesity: An Observational Study
Considering the inadequacy of some antioxidant nutrients in severely obese adolescents, this study aimed to assess the relationship between antioxidant micronutrients status and metabolic syndrome components in metabolically healthy obesity (MHO) and unhealthy obesity (MUO). We performed an observat...
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doaj-3a06ef12508649a09161dd6597515ba72020-11-24T21:57:44ZengMDPI AGNutrients2072-66432018-01-0110215010.3390/nu10020150nu10020150Serum Antioxidant Associations with Metabolic Characteristics in Metabolically Healthy and Unhealthy Adolescents with Severe Obesity: An Observational StudyAna Paula Stenzel0Roberta Carvalho1Patricia Jesus2Aline Bull3Silvia Pereira4Carlos Saboya5Andrea Ramalho6School of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21.941-902, BrazilSchool of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21.941-902, BrazilSchool of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21.941-902, BrazilCenter for Research on Micronutrients (NPqM), Institute of Nutrition Josué de Castro of UFRJ, Rio de Janeiro 21.941-902, BrazilCenter for Research on Micronutrients (NPqM), Institute of Nutrition Josué de Castro of UFRJ, Rio de Janeiro 21.941-902, BrazilCenter for Research on Micronutrients (NPqM), Institute of Nutrition Josué de Castro of UFRJ, Rio de Janeiro 21.941-902, BrazilCenter for Research on Micronutrients (NPqM), Institute of Nutrition Josué de Castro of UFRJ, Rio de Janeiro 21.941-902, BrazilConsidering the inadequacy of some antioxidant nutrients in severely obese adolescents, this study aimed to assess the relationship between antioxidant micronutrients status and metabolic syndrome components in metabolically healthy obesity (MHO) and unhealthy obesity (MUO). We performed an observational study in severely obese adolescents (body mass index > 99th percentile) and they were classified into MHO or MUO, according to the criteria adapted for adolescents. Anthropometric, biochemical, and clinical variables were analyzed to characterize the sample of adolescents. The serum antioxidant nutrients assessed were retinol, β-carotene, Vitamin E, Vitamin C, zinc and selenium. A total of 60 adolescents aged 17.31 ± 1.34 years were enrolled. MHO was identified in 23.3% of adolescents. The MHO group showed lower frequency of non-alcoholic fatty liver disease (14.3% vs. 78.3%, p < 0.001) when compared to MUO. A correlation was found between retinol and β-carotene concentrations with glycemia (r = −0.372; p = 0.011 and r = −0.314; p = 0.034, respectively) and between Vitamin E with waist circumference (r = −0.306; p = 0.038) in the MUO group. The current study shows that some antioxidant nutrients status, specifically retinol, β-carotene, and Vitamin E, are negatively associated with metabolic alterations in MUO. Further studies are necessary to determine the existing differences in the serum antioxidant profile of metabolically healthy and unhealthy obese adolescents.http://www.mdpi.com/2072-6643/10/2/150obesityadolescentsMetabolically Healthy Obesityantioxidants |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana Paula Stenzel Roberta Carvalho Patricia Jesus Aline Bull Silvia Pereira Carlos Saboya Andrea Ramalho |
spellingShingle |
Ana Paula Stenzel Roberta Carvalho Patricia Jesus Aline Bull Silvia Pereira Carlos Saboya Andrea Ramalho Serum Antioxidant Associations with Metabolic Characteristics in Metabolically Healthy and Unhealthy Adolescents with Severe Obesity: An Observational Study Nutrients obesity adolescents Metabolically Healthy Obesity antioxidants |
author_facet |
Ana Paula Stenzel Roberta Carvalho Patricia Jesus Aline Bull Silvia Pereira Carlos Saboya Andrea Ramalho |
author_sort |
Ana Paula Stenzel |
title |
Serum Antioxidant Associations with Metabolic Characteristics in Metabolically Healthy and Unhealthy Adolescents with Severe Obesity: An Observational Study |
title_short |
Serum Antioxidant Associations with Metabolic Characteristics in Metabolically Healthy and Unhealthy Adolescents with Severe Obesity: An Observational Study |
title_full |
Serum Antioxidant Associations with Metabolic Characteristics in Metabolically Healthy and Unhealthy Adolescents with Severe Obesity: An Observational Study |
title_fullStr |
Serum Antioxidant Associations with Metabolic Characteristics in Metabolically Healthy and Unhealthy Adolescents with Severe Obesity: An Observational Study |
title_full_unstemmed |
Serum Antioxidant Associations with Metabolic Characteristics in Metabolically Healthy and Unhealthy Adolescents with Severe Obesity: An Observational Study |
title_sort |
serum antioxidant associations with metabolic characteristics in metabolically healthy and unhealthy adolescents with severe obesity: an observational study |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2018-01-01 |
description |
Considering the inadequacy of some antioxidant nutrients in severely obese adolescents, this study aimed to assess the relationship between antioxidant micronutrients status and metabolic syndrome components in metabolically healthy obesity (MHO) and unhealthy obesity (MUO). We performed an observational study in severely obese adolescents (body mass index > 99th percentile) and they were classified into MHO or MUO, according to the criteria adapted for adolescents. Anthropometric, biochemical, and clinical variables were analyzed to characterize the sample of adolescents. The serum antioxidant nutrients assessed were retinol, β-carotene, Vitamin E, Vitamin C, zinc and selenium. A total of 60 adolescents aged 17.31 ± 1.34 years were enrolled. MHO was identified in 23.3% of adolescents. The MHO group showed lower frequency of non-alcoholic fatty liver disease (14.3% vs. 78.3%, p < 0.001) when compared to MUO. A correlation was found between retinol and β-carotene concentrations with glycemia (r = −0.372; p = 0.011 and r = −0.314; p = 0.034, respectively) and between Vitamin E with waist circumference (r = −0.306; p = 0.038) in the MUO group. The current study shows that some antioxidant nutrients status, specifically retinol, β-carotene, and Vitamin E, are negatively associated with metabolic alterations in MUO. Further studies are necessary to determine the existing differences in the serum antioxidant profile of metabolically healthy and unhealthy obese adolescents. |
topic |
obesity adolescents Metabolically Healthy Obesity antioxidants |
url |
http://www.mdpi.com/2072-6643/10/2/150 |
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